Optimized Sleep After Brain Injury: Sleep Hygiene Intervention After Traumatic Brain Injury (OSABI)

Optimized Sleep After Brain Injury: A Pilot Study

OSABI is a pilot study of a sleep hygiene protocol for sleep disruptions associated with TBI during inpatient rehabilitation. Twenty participants will be allocated (by minimization) either into a standard of care protocol or a sleep hygiene protocol for 4 weeks. Sleep efficiency (via actigraphy), post traumatic amnesia (OLOG), agitation (Agitated Behavior Scale) and cognitive function (Confusion Assessment Protocol) will be monitored during the trial period to examine relationships among them.

Study Overview

• Status: Completed
• Conditions: Traumatic Brain Injury
• Intervention / Treatment: Behavioral: Sleep Hygiene Protocol; Behavioral: Standard of Care

Detailed Description

Estimates of sleep disruption after traumatic brain injury (TBI) reach 81%, but the incidence nature, course and effect on recovery from TBI are not well understood because most TBI sleep studies included mixed TBI severity samples at varied times post injury. In the early rehabilitation phase of recovery from moderate-to-severe TBI, sleep disturbance has been estimated at 78% and has been associated with the presence of post-traumatic amnesia (PTA); a transient period of disorientation, confusion and inability to store memories that occurs after TBI. Individuals with TBI who are in PTA not only have severe memory dysfunction that significantly impairs their ability to benefit from verbal instruction, but are often in a confusional state with agitated behavior. They require a 24-hour, highly structured environment for safety until their PTA resolves. PTA can last from days to weeks, during which time the individual and his/her family are significantly distressed. Its duration also has practical implications in terms of resources, length of hospitalization and cost.

There appears to be a relationship between sleep disturbance and PTA during early recovery from TBI, but the nature of the relationship is not fully understood. Sleep disturbance has been associated with delirium in non-TBI medical patients, and sleep deprivation has been associated with significant negative effects on attention, reaction time, visual-motor performance, language functions, memory processes, and executive functions in normal populations. Sleep disturbance appears to negatively affect cognitive functioning in both medical and normal samples. In the TBI population, sleep disruption could further exacerbate the already compromised cognitive functions and prolong PTA. The relationship between sleep disruption and PTA presents a potentially significant therapeutic opportunity because PTA is largely considered to be fixed and immutable with no therapeutic options. Therapeutic efforts to improve sleep may reduce the length of PTA.

The proposed study will begin to address the gap in knowledge about the nature, incidence and effect of sleep disturbances on recovery from moderate-to-severe TBI during the early rehabilitation period. It will also pilot a sleep hygiene protocol to improve sleep for individuals in the early rehabilitation phase after TBI. It will employ 24-hour per day sleep observations and actigraphy to characterize the incidence and type of sleep disturbances in the early rehabilitation phase of TBI. In addition, the study will serially test participants multiple times a week with the Orientation Log (OLOG) and the Confusion Assessment Protocol (CAP) to closely monitor changes in alertness, orientation, attention, memory functions and behavior as they emerge from PTA. The sleep observations and actigraph information can then be compared to the cognitive measures of PTA to examine the relationship of sleep quantity and quality on cognitive functions during recovery from PTA.

The randomized controlled trial with minimization allocation (RCT) pilot component of the study will be the first therapeutic attempt that we are aware of; to normalize sleep cycles and sleep quality in individuals with TBI who have sleep disruptions during early rehabilitation. Twenty individuals with TBI who have low sleep efficiency on actigraphy during the initial night time screening will be randomized into a comprehensive sleep hygiene protocol (SHP = 10) or a standard of care (SOC = 10) protocol for three weeks. Both groups will have access to all rehabilitation facilities, therapies, services and programs. The difference between the groups is the systematic attempt to improve sleep in the SHP by five principle components: 1) improved night sleep environment, 2) increased daytime activation, 3) enhanced circadian stimuli, 4) morning ADL routines individually adjusted to pre-injury biological sleep patterns and 5) no caffeine intake. In the SOC group, there will be no systematic efforts to influence circadian rhythms, daytime activation or nighttime sleep environment. Participant's sleep in both groups will be monitored with 24-hour actigraphy and staff ratings of sleep-awake periods throughout the 24 hour period on the Makley Sleep Scale (MSS) for four weeks. Additionally, nursing staff will rate agitation on the Agitated Behavior Scale and therapy staff will monitor cognitive functioning with the Orientation Log (OLOG) and Confusion Assessment Protocol (CAP) until after emergence from PTA. The sleep data, cognitive testing and behavioral information for both groups will enable examination of the relationship of sleep to PTA and the potential benefit of the SHP on normalizing sleep and enhancing cognitive recovery, including resolution of PTA.

• Study Type: Interventional
• Enrollment (Actual): 22
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Colorado
    • Englewood, Colorado, United States, 80113
      • Craig Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 14 years to 51 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• All male inpatient admissions to Craig Hospital with the primary diagnosis of TBI
• Rancho Level of Cognitive Functioning Scale >= III
• Ages >= 18 and < =55
• Fluent in the English language
• Available upper extremity for actigraph placement
• Average sleep efficiency= < 75 for three consecutive nights as measured by clinical actigraphy
• Physician judgment that the individual is in post-traumatic amnesia

Exclusion Criteria:

• Medical conditions that require intensive nursing care during the night time sleep period as determined by physician, e.g. tracheostomy
• Hydrocephalus with V-P shunt
• Penetrating Head Injury
• Anoxia associated with TBI
• Stroke associated with TBI
• Spinal cord injury associated with TBI
• Halo Fixation for cervical spine fracture
• Greater than 90 days post injury on admission to Craig Hospital
• Out of Post Traumatic Amnesia on screening
• Severe agitation that would make participation in the study unsafe as determined by the attending physician
• Unable to complete verbal assessments
• History of previous TBI requiring hospitalization
• History of neurodegenerative disease or dementing illness
• History of pre-existing diabetes, pre-disposing factors for diabetes
• History of retinal disease
• History of pre-existing diagnosis of Schizophrenia or Bi-Polar Disorder
• History of Active Major Depressive Illness prior to injury
• History of a diagnosed sleep disorder per family report or medical history
• History of Sleep Disordered Breathing such as sleep apnea as determined by history obtained from significant other/family member or medical history
• History of night shift work or of not being in a consistently standard sleep wake schedule during three months prior to TBI as determined by history obtained from significant other/family member or medical history.
• History of untreated/uncontrolled thyroid disease
• Individuals with epilepsy
• Individuals with central or peripheral blindness
• Body mass index greater than 30.
• Enrollment in a concurrent interventional clinical trial
• Estimated length of stay < 4 weeks
• Medical Proxy unavailable to consent

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Sleep Hygiene Protocol; Participants in this arm will undergo a 4 week sleep hygiene protocol	Behavioral: Sleep Hygiene Protocol; Sleep Hygiene Protocol involving 1) Improved sleep environment 2) Enhanced Circadian Stimuli 3) Increased Daytime Activation (blue light therapy, daytime light exposure and daytime sleep restriction) 4) Adjusted morning ADL routines and 5) Restricted Caffeine intake
Active Comparator: Standard of Care Protocol; Participants will undergo 4 weeks of current inpatient standard of care procedures in a rehabilitation facility	Behavioral: Standard of Care; All standard of care procedures in a specialized traumatic brain injury inpatient rehabilitation unit

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Actiwatch Sleep Efficiency	Sleep efficiency via actigraphy is recorded nightly for 4 weeks	4 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Agitated Behavior Scale	Nursing staff ratings on the Agitated Behavior Scale each shift	4 weeks
Makley Sleep Scale	Staff observations/ratings of sleep every two hours	4 weeks
Orientation Log (O-Log)	Speech Pathology assessment of post traumatic amnesia with the O-Log 5 days per week	4 weeks
Confusion Assessment Protocol (CAP)	Neuropsychology Assessment of cognitive status with the CAP three days per week	4 weeks

Collaborators and Investigators

• Sponsor: Craig Hospital
• Collaborators: Colorado Traumatic Brain Injury Trust Fund

Publications and helpful links

General Publications

• Makley MJ, Gerber D, Newman JK, Philippus A, Monden KR, Biggs J, Spier E, Tarwater P, Weintraub A. Optimized Sleep After Brain Injury (OSABI): A Pilot Study of a Sleep Hygiene Intervention for Individuals With Moderate to Severe Traumatic Brain Injury. Neurorehabil Neural Repair. 2020 Feb;34(2):111-121. doi: 10.1177/1545968319895478. Epub 2019 Dec 30.
• Draganich C, Gerber D, Monden KR, Newman J, Weintraub A, Biggs J, Philippus A, Makley M. Disrupted sleep predicts next day agitation following moderate to severe brain injury. Brain Inj. 2019;33(9):1194-1199. doi: 10.1080/02699052.2019.1631484. Epub 2019 Jun 19.

Study record dates

Study Major Dates

• Study Start (Actual): August 1, 2015
• Primary Completion (Actual): October 1, 2017
• Study Completion (Actual): October 1, 2017

Study Registration Dates

• First Submitted: June 24, 2016
• First Submitted That Met QC Criteria: July 15, 2016
• First Posted (Estimate): July 20, 2016

Study Record Updates

• Last Update Posted (Actual): August 2, 2018
• Last Update Submitted That Met QC Criteria: July 31, 2018
• Last Verified: July 1, 2018

More Information

Terms related to this study

• Keywords: traumatic brain injury; sleep-wake cycle disturbance; circadian disruption
• Additional Relevant MeSH Terms: Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Brain Injuries; Wounds and Injuries; Brain Injuries, Traumatic
• Other Study ID Numbers: 839979IRB