Vascular Responses to High vs Low Repetition Resistance Exercise Training in Young Men

This study evaluates the effects of two types of resistance exercise training (higher-repetition, lower load vs lower-repetition, higher load vs control) on regional and local measures of arterial stiffness in trained young men.

Study Overview

• Status: Completed
• Conditions: Weight-Lifting Exercise Program
• Intervention / Treatment: Behavioral: Lower-repetition, heavier-load; Behavioral: Higher-repetition, lighter-load

• Study Type: Interventional
• Enrollment (Anticipated): 60
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Canada
  • Ontario
    • Hamilton, Ontario, Canada, L8S4L8
      • McMaster University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 30 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• Male
• Aged 18-30 years old
• Non-obese (Body mass index less than 30 kg/m2)
• Non-smoker
• Healthy based on questionnaire responses
• Resistance trained (Resistance training > 2 times per week for 2 years, minimum 1 lower body exercise session per week)

Exclusion Criteria:

• Allergies to milk proteins (whey or casein)
• Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders-all ascertained through medical history screening questionnaires
• Arthritic conditions
• Individuals who consume any analgesic or anti-inflammatory drug(s), prescription or non- prescription, chronically will be excluded
• A history of neuromuscular problems
• Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Resistance exercise training; Whole-body resistance exercise training 4x/week for 12 weeks. Either 'lower-repetition, heavier-load' or 'higher-repetition, lighter-load' intervention.	Behavioral: Lower-repetition, heavier-load; 8-12 reps/set at ~80% 1 repetition maximum; Behavioral: Higher-repetition, lighter-load; 20-25 reps/set at ~30% 1 repetition maximum
No Intervention: Non-exercising control; Continue habitual physical activity for 12 weeks.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Carotid-femoral pulse wave velocity	Assessed using applanation tonometry	12 weeks post exercise training

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Common carotid artery distensibility	Assessed using vascular ultrasound	12 weeks post exercise training
Left ventricular mass	Assessed using standard echocardiography	12 weeks post exercise training

Collaborators and Investigators

• Sponsor: McMaster University

Study record dates

Study Major Dates

• Study Start: September 1, 2014
• Primary Completion (Actual): August 1, 2016
• Study Completion (Actual): August 1, 2016

Study Registration Dates

• First Submitted: July 15, 2016
• First Submitted That Met QC Criteria: July 20, 2016
• First Posted (Estimate): July 25, 2016

Study Record Updates

• Last Update Posted (Estimate): January 16, 2017
• Last Update Submitted That Met QC Criteria: January 13, 2017
• Last Verified: January 1, 2017

More Information

Terms related to this study

• Other Study ID Numbers: REB 14-333-1