Impact of a Training Program on the Body Composition of Overweight and Obese Young Adults : Concentric Versus Eccentric Exercise (OPEX)

October 17, 2016 updated by: University Hospital, Clermont-Ferrand

Nowadays, eccentric exercise can be realized in a dynamic way with an ergocycle wich permits eccentric (ECC) lower limbs contractions at a defined power output. With this type of ergometer, O2 consumption (VO2) in ECC is three fold lower than in concentric (CON) for the same power output. Consequently, ECC program could be used in chronic disorders with limited capacities, such as obesity.

The investigators hypothesis that an eccentric training program, as it will induce higher mechanical constraints, would improve body composition, especially by reducing fat mass. This effect could be explained by an increased rest energy expenditure and a better improvement in biological parameters (particularly lipid profile and insulin-resistance) after ECC training (versus CON training).

This study aims to compare the modification of fat mass after an ECC program versus a CON program at the same VO2. The secondary goal is to assess the physiological mechanisms involved in the modification of body composition

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Detailed Description

Thirty adults will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2weeks) to avoid the secondary muscular effects of high intensity eccentric exercise. The training program will last 12 weeks for the two groups. Before and after, each subjects will participate to the following measurements: total and segmental body composition (DXA), aerobic capacities (maximal incremental exercise test, VO2max), muscular lower limbs strength (isometric end isokinetic dynamometer), rest energy expenditure (indirect calorimetry), biological parameters (lipid profile, insulin-resistance), physical activity (actimetry), food intakes and quality of life (questionnaires).

Study Type

Interventional

Enrollment (Anticipated)

30

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Clermont-Ferrand, France, 63003
        • CHU Clermont-Ferrand

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 35 years (Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • - Adults
  • Obese (BMI>35)
  • Inactive (<10 METS/h/week)
  • No other chronic disease (cardio pulmonary, osteo articulary or muscular diseases), no surgery during the last 3 months, no contraindication to physical activity

Exclusion Criteria:

  • (BMI<35)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: CON : concentric cycling exercise
Thirty adults will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2weeks) to avoid the secondary muscular effects of high intensity eccentric exercise
Other: cycling exercises
Experimental: EXC : eccentric cycling exercise
Thirty adults will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2weeks) to avoid the secondary muscular effects of high intensity eccentric exercise
Other: cycling exercises

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
change in total body fat mass (Dual X ray Absorptiometry)
Time Frame: before and after the 12 weeks training program
before and after the 12 weeks training program

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
aerobic capacities (VO2max)
Time Frame: before and after the 12 weeks training program
before and after the 12 weeks training program
isometric muscular lower limbs strength
Time Frame: before and after the 12 weeks training program
before and after the 12 weeks training program
isokinetic muscular lower limbs strength
Time Frame: before and after the 12 weeks training program
before and after the 12 weeks training program
rest energy expenditure (indirect calorimetry)
Time Frame: before and after the 12 weeks training program
before and after the 12 weeks training program
biological parameters (plasma lipid profile)
Time Frame: before and after the 12 weeks training program
before and after the 12 weeks training program
biological parameters (insulin-resistance)
Time Frame: before and after the 12 weeks training program
before and after the 12 weeks training program
physical activity
Time Frame: before and after the 12 weeks training program
(questionnaires)
before and after the 12 weeks training program
physical activity
Time Frame: before and after the 12 weeks training program
(actimetry)
before and after the 12 weeks training program
food intakes
Time Frame: before and after the 12 weeks training program
(measurements)
before and after the 12 weeks training program
food intakes
Time Frame: before and after the 12 weeks training program
(questionnaires)
before and after the 12 weeks training program
quality of life (questionnaires)
Time Frame: before and after the 12 weeks training program
before and after the 12 weeks training program
segmental body composition
Time Frame: before and after the 12 weeks training program
(segmental fat and fat free mass)
before and after the 12 weeks training program

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospital, Clermont-Ferrand

Investigators

  • Principal Investigator: Valérie JULIAN, University Hospital, Clermont-Ferrand

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2017

Primary Completion (Anticipated)

December 1, 2019

Study Completion (Anticipated)

January 1, 2020

Study Registration Dates

First Submitted

October 10, 2016

First Submitted That Met QC Criteria

October 17, 2016

First Posted (Estimate)

October 19, 2016

Study Record Updates

Last Update Posted (Estimate)

October 19, 2016

Last Update Submitted That Met QC Criteria

October 17, 2016

Last Verified

October 1, 2016

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CHU-0284
  • 2016-A01185-46 (Other Identifier: 2016-A01185-46)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Adults

Clinical Trials on cycling exercises

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Slovenia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

3
Subscribe