Impact of a Training Program on the Body Composition of Overweight and Obese Young Adults : Concentric Versus Eccentric Exercise (OPEX)

Nowadays, eccentric exercise can be realized in a dynamic way with an ergocycle wich permits eccentric (ECC) lower limbs contractions at a defined power output. With this type of ergometer, O2 consumption (VO2) in ECC is three fold lower than in concentric (CON) for the same power output. Consequently, ECC program could be used in chronic disorders with limited capacities, such as obesity.

The investigators hypothesis that an eccentric training program, as it will induce higher mechanical constraints, would improve body composition, especially by reducing fat mass. This effect could be explained by an increased rest energy expenditure and a better improvement in biological parameters (particularly lipid profile and insulin-resistance) after ECC training (versus CON training).

This study aims to compare the modification of fat mass after an ECC program versus a CON program at the same VO2. The secondary goal is to assess the physiological mechanisms involved in the modification of body composition

Study Overview

• Status: Unknown
• Conditions: Adults; BMI>35
• Intervention / Treatment: Other: cycling exercises

Detailed Description

Thirty adults will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2weeks) to avoid the secondary muscular effects of high intensity eccentric exercise. The training program will last 12 weeks for the two groups. Before and after, each subjects will participate to the following measurements: total and segmental body composition (DXA), aerobic capacities (maximal incremental exercise test, VO2max), muscular lower limbs strength (isometric end isokinetic dynamometer), rest energy expenditure (indirect calorimetry), biological parameters (lipid profile, insulin-resistance), physical activity (actimetry), food intakes and quality of life (questionnaires).

• Study Type: Interventional
• Enrollment (Anticipated): 30
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Clermont-Ferrand, France, 63003
    • CHU Clermont-Ferrand

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 35 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• - Adults
• Obese (BMI>35)
• Inactive (<10 METS/h/week)
• No other chronic disease (cardio pulmonary, osteo articulary or muscular diseases), no surgery during the last 3 months, no contraindication to physical activity

Exclusion Criteria:

• (BMI<35)

Study Plan

How is the study designed?

Design Details

• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: CON : concentric cycling exercise; Thirty adults will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2weeks) to avoid the secondary muscular effects of high intensity eccentric exercise	Other: cycling exercises
Experimental: EXC : eccentric cycling exercise; Thirty adults will be randomized into 2 groups: CON or EXC. The patients of ECC group will follow habituation sessions (2weeks) to avoid the secondary muscular effects of high intensity eccentric exercise	Other: cycling exercises

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
change in total body fat mass (Dual X ray Absorptiometry)	before and after the 12 weeks training program

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
aerobic capacities (VO2max)		before and after the 12 weeks training program
isometric muscular lower limbs strength		before and after the 12 weeks training program
isokinetic muscular lower limbs strength		before and after the 12 weeks training program
rest energy expenditure (indirect calorimetry)		before and after the 12 weeks training program
biological parameters (plasma lipid profile)		before and after the 12 weeks training program
biological parameters (insulin-resistance)		before and after the 12 weeks training program
physical activity	(questionnaires)	before and after the 12 weeks training program
physical activity	(actimetry)	before and after the 12 weeks training program
food intakes	(measurements)	before and after the 12 weeks training program
food intakes	(questionnaires)	before and after the 12 weeks training program
quality of life (questionnaires)		before and after the 12 weeks training program
segmental body composition	(segmental fat and fat free mass)	before and after the 12 weeks training program

Collaborators and Investigators

• Sponsor: University Hospital, Clermont-Ferrand
• Investigators: Principal Investigator: Valérie JULIAN, University Hospital, Clermont-Ferrand

Study record dates

Study Major Dates

• Study Start: January 1, 2017
• Primary Completion (Anticipated): December 1, 2019
• Study Completion (Anticipated): January 1, 2020

Study Registration Dates

• First Submitted: October 10, 2016
• First Submitted That Met QC Criteria: October 17, 2016
• First Posted (Estimate): October 19, 2016

Study Record Updates

• Last Update Posted (Estimate): October 19, 2016
• Last Update Submitted That Met QC Criteria: October 17, 2016
• Last Verified: October 1, 2016

More Information

Terms related to this study

• Keywords: obesity; body composition; training program; eccentric exercise
• Additional Relevant MeSH Terms: Body Weight; Overweight
• Other Study ID Numbers: CHU-0284; 2016-A01185-46 (Other Identifier: 2016-A01185-46)