Serum Preptin and Amylin Levels in Polycystic Ovary Syndrome Patients

Serum Preptin and Amylin Levels With Respect to Body Mass Index in Polycystic Ovary

Preptin and amylin are pancreatic hormones which participate in glucose homeostasis. This study aims to evaluate how serum preptin and amylin levels are altered in polycystic ovary syndrome (PCOS) patients and healthy women based on BMI groups .

Study Overview

• Status: Completed
• Conditions: Polycystic Ovary Syndrome
• Intervention / Treatment: Diagnostic test: preptin and amylin level

Detailed Description

Materials and Methods: This is a cross-sectional review of 40 PCOS patients and 40 healthy women who were matched with respect to BMI (<25 kg/m2 and ≥25 kg/m2).

• Study Type: Observational
• Enrollment (Actual): 80

Contacts and Locations

Study Locations

• Turkey
  • Rize, Turkey, 53000
    • Recep Tayyip Erdoğan University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 17 years to 35 years (ADULT, CHILD)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Female

• Sampling Method: Probability Sample

Study Population

Polycystic ovary syndrome

Description

Inclusion Criteria:

the patients with PCOS

Exclusion Criteria:

Cushing's syndrome 21-hydroxylase deficiency Congenital adrenal hyperplasia Thyroid dysfunction Hyperprolactinemia Diabetes Chronic cardiovascular Hepatic, renal, and hematologic diseases Malignancies Using oral contraceptives, anti-androgens, glucocorticoids, anti-hypertensives, anti-diabetics, calcium supplements and anti-obesity drugs and those who smoke or consume alcohol

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Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Polycyctic ovary sendrome (PCOS); these women who have PCOS, we will use their blood samples	Diagnostic test: preptin and amylin level; we will take both of group blood samples to compare them serum preptin and amylin
Healty groups; These women who have reguler menstrual cycle, no akne or hirsutism, we will use their boold samples	Diagnostic test: preptin and amylin level; we will take both of group blood samples to compare them serum preptin and amylin

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Serum Preptin and Amylin Levels with Respect to Body Mass Index in Polycystic Ovary Syndrome Patients	Serum Preptin and Amylin Levels will compare between groups	six months

Collaborators and Investigators

• Sponsor: Recep Tayyip Erdogan University Training and Research Hospital
• Investigators: Study Director: Senol sentürk, PhD, Recep Tayyip Erdoğan University

Study record dates

Study Major Dates

• Study Start (ACTUAL): June 28, 2017
• Primary Completion (ACTUAL): November 30, 2017
• Study Completion (ACTUAL): December 7, 2017

Study Registration Dates

• First Submitted: June 12, 2018
• First Submitted That Met QC Criteria: July 13, 2018
• First Posted (ACTUAL): July 16, 2018

Study Record Updates

• Last Update Posted (ACTUAL): July 16, 2018
• Last Update Submitted That Met QC Criteria: July 13, 2018
• Last Verified: July 1, 2018

More Information

Terms related to this study

• Keywords: amylin; obesity; polycystic ovarian syndrome; preptin
• Additional Relevant MeSH Terms: Pathologic Processes; Neoplasms; Endocrine System Diseases; Disease; Ovarian Cysts; Cysts; Ovarian Diseases; Adnexal Diseases; Gonadal Disorders; Polycystic Ovary Syndrome; Syndrome
• Other Study ID Numbers: 107

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No