The Impact of Artificial Sunlight on Human Sleep and Circadian Rhythms

March 29, 2021 updated by: Jamie M. Zeitzer, Ph.D., VA Palo Alto Health Care System
The purpose of this study is to examine, in healthy controls, whether LED lighting that has a color spectrum similar to that of sunlight is able to differentially impact mood, circadian rhythms, sleep, and behavior, as compared to standard fluorescent lighting.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

10

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • California
      • Palo Alto, California, United States, 94304
        • VA Palo Alto Health Care System

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 35 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Good self-reported health
  • Normal color vision

Exclusion Criteria:

  • No sleep disorders
  • No extreme chronotype
  • Regular smoker
  • Significant hearing loss
  • Depression
  • Alcohol use disorder
  • Use of illegal drugs
  • Pregnant

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: LED - Sunlike
LED lighting with spectral pattern similar to that of sunlight
Device: Light
15 hours of light exposure
Active Comparator: Fluorescent
Fluorescent light at same illuminance (lux) as LED light
Device: Light
15 hours of light exposure
Placebo Comparator: Dim
Dim fluorescent light with same spectrum as "Fluorescent" condition
Device: Light
15 hours of light exposure
Active Comparator: LED
Standard LED lighting
Device: Light
15 hours of light exposure

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Alertness
Time Frame: 15 hours
Change in median reaction time score on the auditory psychomotor vigilance test
15 hours
Melatonin suppression
Time Frame: 3 hours
Amount of reduction in the concentration of salivary melatonin concentrations during an experimental light stimulus
3 hours

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Mood
Time Frame: 15 hours
Change in total positive and negative affect scores on the Positive and Negative Affect Schedule (PANAS)
15 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

VA Palo Alto Health Care System

Collaborators

Seoul Semiconductor

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

July 1, 2019

Primary Completion (Actual)

March 1, 2021

Study Completion (Actual)

March 1, 2021

Study Registration Dates

First Submitted

August 2, 2018

First Submitted That Met QC Criteria

August 15, 2018

First Posted (Actual)

August 17, 2018

Study Record Updates

Last Update Posted (Actual)

March 30, 2021

Last Update Submitted That Met QC Criteria

March 29, 2021

Last Verified

March 1, 2021

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Sunlike

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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