- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03774862
Clinicopathological Importance of Colorectal Medullary Carcinoma: Retrospective Cohort Study
December 12, 2018 updated by: Serkan Zenger MD, V.K.V. American Hospital, Istanbul
Medullary carcinoma (MC) is a rare tumor with solid growth pattern without glandular differentiation and constitute less than 1% of colorectal cancer.
Lymph node positivity and distant organ metastasis were reported to be lower than other poorly differentiated adenocarcinomas.
Therefore, the diagnosis of MC is pathologically important in terms of follow-up and treatment.
MC is commonly localized in the right colon, has a large tumor size, and is mostly diagnosed in the T4 stage.
As MC most likely have defects in DNA MMR, the correct pathological diagnosis is important for the postoperative treatment and the prognosis of the patients.
Study Overview
Status
Completed
Conditions
Detailed Description
427 patients with colorectal cancer who were underwent surgery between January 2011 and December 2017, were evaluated retrospectively into 2 groups as MC (n:13) and non-MC (n:414) in terms of demographic characteristics, pathological data and oncological outcomes.
Study Type
Observational
Enrollment (Actual)
13
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
427 patients with colorectal cancer who were underwent surgery between January 2011 and December 2017, were evaluated retrospectively into 2 groups as MC (n:13) and non-MC (n:414) in terms of demographic characteristics, pathological data and oncological outcomes.
Description
Inclusion Criteria:
- colorectal cancer diagnosis, medullary carcinoma
Exclusion Criteria:
- none
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Retrospective
Cohorts and Interventions
Group / Cohort |
---|
Medullary carcinoma of colorectal cancers
|
non-medullary carcinomas of the colorectal cancers
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Overall survival of medullar colorectal carcinomas
Time Frame: 7 years
|
7 years
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 1, 2011
Primary Completion (Actual)
December 31, 2017
Study Completion (Actual)
August 1, 2018
Study Registration Dates
First Submitted
September 5, 2018
First Submitted That Met QC Criteria
December 12, 2018
First Posted (Actual)
December 13, 2018
Study Record Updates
Last Update Posted (Actual)
December 13, 2018
Last Update Submitted That Met QC Criteria
December 12, 2018
Last Verified
December 1, 2018
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Neoplasms by Histologic Type
- Neoplasms
- Neoplasms by Site
- Adenocarcinoma
- Neoplasms, Glandular and Epithelial
- Endocrine System Diseases
- Endocrine Gland Neoplasms
- Thyroid Diseases
- Head and Neck Neoplasms
- Neuroectodermal Tumors
- Neoplasms, Germ Cell and Embryonal
- Neoplasms, Nerve Tissue
- Neuroendocrine Tumors
- Neoplasms, Ductal, Lobular, and Medullary
- Carcinoma
- Thyroid Neoplasms
- Carcinoma, Neuroendocrine
- Carcinoma, Medullary
Other Study ID Numbers
- VKVAmericanH
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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