Respiratory Complications Among Living Liver-donors

Respiratory Complications Among Living Liver-donors: a Single Center Observational Retrospective Study

Recently, there are increasing reports about pulmonary complications within living liver donors postoperatively. In this retrospective study, the investigators will highlight the risk factors and incidence of pulmonary complication among living liver-donors in our center.

Study Overview

• Status: Unknown
• Conditions: Complication of Anesthesia
• Intervention / Treatment: Procedure: Collection of data

• Study Type: Observational
• Enrollment (Anticipated): 124

Contacts and Locations

Study Locations

• Egypt
  • Cairo, Egypt, 11591
    • Ain Shams university hospitals

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 50 years (Adult)
• Accepts Healthy Volunteers: N/A
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Donors who underwent hepatic lobectomy for liver transplantation

Description

Inclusion Criteria:

• Excellent general physical and mental condition,
• Free of chronic disease or
• Previous major abdominal surgery,
• Body mass index (BMI) <28,
• ABO blood group identical to recipients and
• Negative for hepatitis B, C and human immunodeficiency viruses (HIV).

Exclusion Criteria:

• ASA physical status> II,
• BMI>28,
• Psychiatric or mental retardation,
• pregnant and nursing women or
• Patients with significant laboratory abnormalities

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The number of participants with postoperative respiratory complications	Respiratory complications as pulmonary embolism, pleural effusion, pneumothorax, pneumonia, atelectasis, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and transfusion-related acute lung injury (TRALI) will be considered when they are clinically evident.	an average period of 3 year

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The average of ICU stay among patients	It is defined as time period from entry to ICU till discharge to the ward	an average period of 3 year
The average of hospital stay among patients	It is defined as time period elapsed from discharge to the ward till leaving the hospital	an average period of 3 year

Collaborators and Investigators

• Sponsor: Ain Shams University

Study record dates

Study Major Dates

• Study Start (Actual): February 6, 2019
• Primary Completion (Anticipated): April 1, 2019
• Study Completion (Anticipated): May 1, 2019

Study Registration Dates

• First Submitted: February 25, 2019
• First Submitted That Met QC Criteria: March 1, 2019
• First Posted (Actual): March 5, 2019

Study Record Updates

• Last Update Posted (Actual): March 5, 2019
• Last Update Submitted That Met QC Criteria: March 1, 2019
• Last Verified: February 1, 2019

More Information

Terms related to this study

• Other Study ID Numbers: FAMSU R37/2018

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No