Exploration of Angiogenesis in Decompensated Developmental Venous Abnormalities (Explor-AVD)

August 2, 2022 updated by: Hopital Foch
The purpose of our study is to demonstrate by blood samples in situ in the vascular lesion (performed during any cerebral catheterization for an embolization of arteriovenous malformation) the existence of angiogenic growth factors and inflammatory factors that would confirm the decompensation of venous ischemia.

Study Overview

Status

Terminated

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

3

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Suresnes, France
        • Hopital Foch

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Main Inclusion Criteria:

  • Presenting a DVA requiring hyperselective catheterization
  • Having sign an informed consent form

Exclusion Criteria:

  • Presenting a contraindication to the realization of hyperselective cathterism

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: BASIC_SCIENCE
  • Allocation: NA
  • Interventional Model: SINGLE_GROUP
  • Masking: NONE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
EXPERIMENTAL: Blood sample
Blood sampling Under general anesthesia
Procedure: Blood sampling
Blood sampling under general anesthesia

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Assessment of angiogenic and inflammatory growth factors
Time Frame: 1 day
The 1st factor studied is VEGF-A
1 day
Assessment of angiogenic and inflammatory growth factors
Time Frame: 1 day
The 2nd factor studied is VEGF-A
1 day
Assessment of angiogenic and inflammatory growth factors
Time Frame: 1 day
The 3rd factor studied is angiopoitin-2
1 day
Assessment of angiogenic and inflammatory growth factors
Time Frame: 1 day
The 4th factor studied is PDGF
1 day
Assessment of angiogenic and inflammatory growth factors
Time Frame: 1 day
The 5th factor studied is angiopoietin-like 4
1 day

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Hopital Foch

Collaborators

Collège de France

Investigators

  • Principal Investigator: Georges Rodesch, Hopital Foch

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (ACTUAL)

January 11, 2018

Primary Completion (ACTUAL)

January 11, 2021

Study Completion (ACTUAL)

January 11, 2021

Study Registration Dates

First Submitted

June 13, 2019

First Submitted That Met QC Criteria

June 13, 2019

First Posted (ACTUAL)

June 14, 2019

Study Record Updates

Last Update Posted (ACTUAL)

August 4, 2022

Last Update Submitted That Met QC Criteria

August 2, 2022

Last Verified

August 1, 2022

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2017007-F

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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