- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04140994
Innovative Brain Stimulation for Induction of Learning Plasticity
Effects of rTMS on Brain Plasticity and Motor Learning in Healthy People.
Study Overview
Detailed Description
Participants will participate in 1 session of neuronavigated (TMS Navigator, Localite, Schloss Birlinghoven, D-53757, Sankt Augustin, Germany ) iTBS (patterned form of rTMS) coupled with motor learning. Participants will be randomly assigned to one of 2 groups: real iTBS over parietal cortex and sham iTBS over the parietal cortex.
One day before (Day1) and after the motor learning (Day 2), participants will undergo high-density 128-channel resting state electroencephalography (EEG) and motor evoked potential (MEP) in order to characterize the effects of rTMS on our markers of plasticity. Performance on the task will be measure immediately after learning (Day 2) and again 24h later (Day 3) in order to test for retention and offline consolidation (time and errors). The task will consist in realizing a computerized mirror-drawing task, in which right-left movements of the mouse were reversed on the screen.
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Pierre Nicolo, PhD
- Phone Number: +41 (0)22 372 38 76
- Email: pierre.nicolo@hcuge.ch
Study Contact Backup
- Name: Pierre Nicolo, PhD
- Phone Number: +41792633543
- Email: nicolopierre@gmail.com
Study Locations
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-
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Geneva, Switzerland, 1211
- Recruiting
- Pierre Nicolo
-
Contact:
- Pierre Nicolo
- Phone Number: 0792633543
- Email: pierre.nicolo@hcuge.ch
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- man or woman aged between 18-40 years,
- ability to give informed consent,
- ability to follow protocol instructions,
- normal or corrected-to-normal vision,
Exclusion Criteria:
- history of epileptic seizure (ci. TMS),
- skull breach (ci. TMS),
- metallic object in the brain (ci. TMS),
- pacemaker (ci. TMS),
- severe co-morbidity (ex, traumatic, rheumatologic, neurodegenerative diseases),
- pregnancy.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Intermittent theta burst stimulation
Volunteers will be submitted to non-invasive parietal stimulation before a mirror drawing task. A transcranial magnetic stimulator (MagPro X100, Medtronic Functional Diagnostics, Skovlunde, Denmark) will deliver interrmittent bursts of bipolar magnetic pulses exerting an excitation on the underlying brain tissue (iTBS). The stimulation coil will be placed over the parietal cortex. Stimulation consisted of a burst of three pulses administered at 50Hz, repeated at a frequency of 5Hz, delivered in 2 s trains followed by an 8 s interval for a total of 600 pulses12. Stimulation intensity was set at 70% of RMT. Each session will consist of two spaced neuronavigated iTBS applications, separated by 15 minutes. |
Participants will participate in 1 session of neuronavigated (TMS Navigator, Localite, Schloss Birlinghoven, D-53757, Sankt Augustin, Germany ) iTBS (patterned form of TMS) coupled with motor learning.
|
Sham Comparator: Sham intermittent theta burst stimulation
For sham iTBS, the protocol is the same, except the sham coil produces no magnetic field.
|
Participants will participate in 1 session of neuronavigated (TMS Navigator, Localite, Schloss Birlinghoven, D-53757, Sankt Augustin, Germany ) iTBS (patterned form of TMS) coupled with motor learning.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Motor performance in consolidation test
Time Frame: after training (Day 3)
|
Difference in error rate and speed improvement in active and sham groups (learned task)
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after training (Day 3)
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Resting state EEG connectivity in active and sham groups
Time Frame: Before (Day 1) and after training (Day 2)
|
Calculated from electroencephalography recordings
|
Before (Day 1) and after training (Day 2)
|
Motor Evoked Potential (MEPs) Amplitudes (peak to peak)
Time Frame: Before (Day 1) and after training (Day 2)
|
Difference in MEPs between active and sham groups.
MEPs are generated when stimulation of the brain on the motor cortex (with Transcranial Magnetic Stimulation [TMS]) causes the spinal cord and peripheral muscles to produce neuroelectrical signals.
MEPs are typically measured in the hand muscles (Abductor pollicis brevis ).
|
Before (Day 1) and after training (Day 2)
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Motor performance in retention test
Time Frame: After training (Day 2)
|
Difference in error rate and speed improvement in active and sham groups (learned task)
|
After training (Day 2)
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Motor performance in transfer test
Time Frame: after training (Day 2 and Day 3)
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Difference in error rate and speed improvement in active and sham groups (non-learned) task)
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after training (Day 2 and Day 3)
|
Collaborators and Investigators
Investigators
- Study Director: Adrian Guggisberg, Prof. Dr., University Hospital, Geneva
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- Project-ID 2019-01440 CCER
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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