Association Between Mother and Child Weight Gain: Statistical Methods With Validation

Using retrospective data from the Vanderbilt University Medical Center electronic health record, the investigators will study the association between mother's weight / weight change before and during pregnancy and the development of childhood obesity up until 5 years of age.

Study Overview

• Status: Completed
• Conditions: Obesity, Childhood

Detailed Description

The investigators are extracting de-identified retrospective data from the Vanderbilt University Medical Center electronic health record for mother-child pairs. From this data, the investigators will study the association between mother weight change during pregnancy and the risk of her child developing obesity during the first 5 years of life. Included mothers must have at least one weight measurement and at least one height measurement; they must have at least one child with weight/length measurements at birth and one additional same day height/weight measurement at or before 5 years of age.

• Study Type: Observational
• Enrollment (Actual): 20670

Contacts and Locations

Study Locations

• United States
  • Tennessee
    • Nashville, Tennessee, United States, 37232
      • Vanderbilt University Medical Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 1 second and older (Child, Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Mothers who have delivered at VUMC and their children who are seen by Vanderbilt-affiliated physicians.

Description

Inclusion Criteria:

• Mother-child pairs in the Vanderbilt University Medical Center (VUMC) electronic health record.
• The mothers must have at least one height measurement.
• The mothers must also have at least one weight measurement during pregnancy.
• The child must have birth length and weight measures and at least one same day height/weight measurement during their first 5 years of life.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Mother-Child; Mothers who have delivered at VUMC and their children who are seen by Vanderbilt-affiliated physicians.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Obesity of the Child (in the Mother-child Pair) During the First 5 Years of the Child's Life	Obesity of the child is defined as having a BMI-by-age classification greater than the 95th percentile based on the US CDC percentiles.	first 5 years of child's life

Collaborators and Investigators

• Sponsor: Vanderbilt University Medical Center
• Collaborators: Patient-Centered Outcomes Research Institute; University of Pennsylvania
• Investigators: Principal Investigator: Bryan Shepherd, PhD, Vanderbilt University Medical Center

Study record dates

Study Major Dates

• Study Start (Actual): June 26, 2019
• Primary Completion (Actual): August 1, 2021
• Study Completion (Actual): August 1, 2021

Study Registration Dates

• First Submitted: November 20, 2019
• First Submitted That Met QC Criteria: November 20, 2019
• First Posted (Actual): November 22, 2019

Study Record Updates

• Last Update Posted (Actual): January 31, 2022
• Last Update Submitted That Met QC Criteria: January 27, 2022
• Last Verified: January 1, 2022

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Overnutrition; Nutrition Disorders; Overweight; Body Weight; Body Weight Changes; Obesity; Pediatric Obesity; Weight Gain
• Other Study ID Numbers: 190557

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No