- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04425083
Relationship of the Chinese Medical Constitution & Syndromes in Patients With Polycystic Ovary Syndrome
June 6, 2020 updated by: Chien-Jung Lin, Tri-Service General Hospital
Study of the Relationship of the Chinese Medical Constitution & Syndromes and Quality of Life in Patients With Polycystic Ovary Syndrome
This study is a cross-sectional study.
The purpose is to understand the characteristics of Chinese medicine constitutional syndrome in patients with polycystic ovary.
In addition, the health-related quality of life (SF-36), mental state (stress, depression) of patients with polycystic ovary , Anxiety) and the relationship between hormone biochemical indicators and TCM constitutional syndromes, to develop a pioneering study on TCM constitution diagnosis and life guidelines for polycystic ovarian patients and future clinical adjuvant therapy.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
The study conducted in the Obstetrics and Gynecology Department of the Neihu District of the Taipei Three Military General Hospital.
It is expected that 200 cases of polycystic ovary will be diagnosed by specialists; "Quality of Life Questionnaire (SF-36)" evaluates the quality of life of patients; "BAI and BDI-II" evaluates patients 'anxiety and depression; "Stress Perception Scale" evaluates patients' life stress And testing the blood indexes of patients such as FSH, LH, E2, testosterone, TSH, prolactine.
Observe the correlation between the quality of life, psychological state, and blood test values of polycystic ovarian patients with physical characteristics of traditional Chinese medicine.
Study Type
Observational
Enrollment (Actual)
180
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
20 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
Female
Sampling Method
Non-Probability Sample
Study Population
Women diagnosed with Polycystic Ovary Syndrome and non Polycystic Ovary Syndrome
Description
Inclusion Criteria:
A polycystic ovarian patient was diagnosed by a specialist in obstetrics and gynecology according to the diagnostic criteria set by the Rotterdam ESHRE / ASRM-sponsored PCOS workshop group (2004) in 2003.
Exclusion Criteria:
- Exclude diseases similar to the clinical manifestations of polycystic ovary, such as cushing syndrome, congenital adrenal hyperplasia, thyroid dysfunction, and hyperprolactinemia.
- Diagnose a clear mental disorder (such as schizophrenia, severe depression) or take psychiatric drugs (anti-depression or anxiety drugs).
- Pregnancy, oral contraceptives, use high-dose exogenous androgens, breastfeeding.
- Those with a history of stroke, myocardial infarction, major trauma or surgery within the past six months.
- Have taken Chinese medicine in the past month.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Polycystic Ovary Syndrome
Polycystic Ovary Syndrome women
|
no intervention
|
control
non- Polycystic Ovary Syndrome women
|
no intervention
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
participants with PCOS and non-PCOS assessed Chinese Body Constitution & Syndromes by Body Constitution Questionnaire
Time Frame: No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
The TCM Body Constitution Questionnaire (BCQ) was developed by Su and is a tool used to measure and study constitution deviations clinically.
The questionnaire comprises 44 questions and employs a Likert 5-point scale (from 1, "Never happens," to 5, "Always happens").
The instrument consists of three subscales.
The yang-xu and yin-xu constitution subscales each have 19 questions, and the stasis constitution subscale has 16 questions.
The three measures share some questions.
The higher the score is, the more significant the constitution deviation is.
When the yang-xu constitution score is ≥ 30.5, the respondent is diagnosed as yang-xu.
When the yin-xu constitution score is ≥ 29.5, the respondent is diagnosed as yin-xu.
For the phlegm stasis constitution, the standard is ≥ 26.5 points.
The instrument has favorable factorial validity.
Cronbach's α of each subscale is 0.85-0.88,
and Cronbach's αof the overall BCQ reaches 0.90.
|
No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
work schedule (Day shift, Evening shift, Night shift, Not fixed, or Unemployed) of participants with PCOS and non-PCOS were collected
Time Frame: No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
Participant reply her work schedule (Day shift, Evening shift, Night shift, Not fixed, or Unemployed)
|
No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
average sleep duration of participants with PCOS and non-PCOS were collected
Time Frame: No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
Participant reply her average sleep duration (hours)
|
No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
habit of staying up late of participants with PCOS and non-PCOS were collected
Time Frame: No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
Participant reply her frequency(No, Sometimes, Often) of staying up late (sleeping after midnight)
|
No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
habit of smoking of participants with PCOS and non-PCOS were collected
Time Frame: No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
Participant reply her frequency of smoking (No, Sometimes, Less than a pack a day)
|
No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
habit of drinking of participants with PCOS and non-PCOS were collected
Time Frame: No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
Participant reply her frequency of drinking (No, Sometimes, often)
|
No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
habit of exercise of participants with PCOS and non-PCOS were collected
Time Frame: No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
Participant reply her frequency of exercise (No, Sometimes, often)
|
No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
dietary habit (Nonvegetarian or vegetarian) of participants with PCOS and non-PCOS were collected
Time Frame: No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
Participant reply her dietary habit (Nonvegetarian or vegetarian)
|
No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
dietary flavor preference (sour, bitter,sweet, spicy, salty) of participants with PCOS and non-PCOS were collected
Time Frame: No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
Participant reply yes or no about her dietary flavor preference (sour, bitter,sweet, spicy, salty)
|
No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
Anxiety of participants with PCOS and non-PCOS as assessed by Beck Anxiety Inventory
Time Frame: No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
The Beck Anxiety Inventory (BAI) was established by Aaron T. Beck and his research team to measure the anxiety levels of adults and teenagers.
It is a self-completed questionnaire with 21 items.
The questions ask respondents whether they have experienced some common symptoms of anxiety in the previous week, including numbness or tingling, feeling hot, being unable to relax, and fear of the worst happening.
The respondents report on a 4-point Likert scale that ranges from 0 (Not at all) to 3 (Severely - it bothered me a lot).
The higher the total score is, the more severe the anxiety symptoms are.
A total score of 0-7 implies the mildest anxiety, 8-15 is mild anxiety, 16-25 represents moderate anxiety, and 26-63 is severe anxiety.
In the present study, the Chinese version of the BAI had a Cronbach's α of 0.95 and a split-half reliability of 0.92.
The total scores were multiplied by 1.19, and the resulted integers were taken as the standard scores.
|
No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
Depression of participants with PCOS and non-PCOS as assessed by Beck Depression Inventory-second edition (BDI-II)
Time Frame: No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
The Beck Depression Inventory-second edition (BDI-II) was developed by Beck .
It measures the depression levels of teenagers and adults through 21 questions.
It consists of questions representative of the symptoms and attitudes of depression, such as feeling sad, losing interest, decreased appetite, and feeling tired.
For each item, respondents select the option that best describes how they felt over the previous 2 weeks.
Every question has anchors arranged according to severity, and the score ranges from 0 to 3 points.
The higher the total score is, the more severe the depression symptoms are.
A total score of 0-13 points is in the normal range, 14-19 implies mild depression, 20-28 moderate depression, and 29-63 severe depression.
|
No subsequent intervention, data collected and analyzed at the time of enrolled (cross-sectional study)
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
November 18, 2015
Primary Completion (Actual)
December 31, 2017
Study Completion (Actual)
December 31, 2017
Study Registration Dates
First Submitted
May 23, 2020
First Submitted That Met QC Criteria
June 6, 2020
First Posted (Actual)
June 11, 2020
Study Record Updates
Last Update Posted (Actual)
June 11, 2020
Last Update Submitted That Met QC Criteria
June 6, 2020
Last Verified
June 1, 2020
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- TSGH-C105-025
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Polycystic Ovary Syndrome
-
Cairo UniversityCompleted
-
Alexandria UniversityRecruitingPolycystic Ovary Syndrome (PCOS)Egypt
-
Saudi German Hospital - MadinahCompletedPolycystic Ovary Syndrome (PCOS)Saudi Arabia
-
University of CopenhagenCompletedPolycystic Ovary Syndrome (PCOS)Denmark
-
Odense University HospitalCompleted
-
Poznan University of Medical SciencesUniversity of California, DavisUnknownPolycystic Ovary Syndrome (PCOS)Poland
-
Mansoura UniversityNot yet recruitingPCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries
-
Assaf-Harofeh Medical CenterUnknownInfertility | Polycystic OvariesIsrael
-
Riphah International UniversityCompleted
-
Dexa Medica GroupCompletedPolycystic Ovary Syndrome (PCOS)Indonesia
Clinical Trials on no intervention
-
Wave NeuroscienceCompletedAutistic DisorderUnited States
-
University of Alabama at BirminghamCompletedInflammatory Bowel Diseases | Colorectal Cancer | Diverticular Diseases | Social BehaviorUnited States
-
Janssen Research & Development, LLCCompletedLupus Erythematosus, Systemic | Lupus Erythematosus, Cutaneous | Lupus Erythematosus, DiscoidUnited States, Poland
-
Hospital Universitario La Paz3MVX CCB and Agaplesion Markus Krankenhaus, Frankfurt a.M., Germany.; Department...RecruitingEmbolism | Atrial Fibrillation | Arrhythmia | Stroke, Acute | Stroke Sequelae | AblationSpain
-
Southern California College of Optometry at Marshall...Ohio State University; University of Houston; Alcon Research; University of Waterloo and other collaboratorsCompletedContact Lens Complication | Contact Lens Acute Red Eye | Contact Lens Related Corneal Infiltrate (Disorder) | Contact Lens-Induced Corneal Fluorescein StainingUnited States, Canada
-
Case Western Reserve UniversityAmerican University; Purdue UniversityRecruiting
-
China Medical University HospitalUnknownIntention to Stay, Turnover Behavior
-
University of Dublin, Trinity CollegeCompleted
-
Hôpital Necker-Enfants MaladesUnknown