Intensive Care Therapy of Covid-19 Disease in Germany

Intensive Care Therapy of Covid-19 Disease in Germany an Multi-center Observational Study

Multi-center retrospective and prospective observational study of Covid-19 patients with severe or critical illness treated on a German ICU

Study Overview

• Status: Completed
• Conditions: COVID; ARDS

• Study Type: Observational
• Enrollment (Actual): 2054

Contacts and Locations

Study Locations

• Germany
  • Aachen, Germany
    • RWTH Aachen - Department for operative Intensive Care Medicine and intermediate Care
  • Balingen, Germany
    • Zollernalbklinikum
  • Berlin, Germany
    • Charité Universitätsmedizin Berlin
  • Bochum, Germany
    • UH Bochum - Department for Anesthesiology and Intensive Care Medicine
  • Bonn, Germany
    • Universitätsklinikum Bonn
  • Dresden, Germany
    • Universitätsklinikum Carl Gustav Carus Dresden
  • Duisburg, Germany
    • Ev. Krankenhaus Bethesda Duisburg Klinik für Anästhesiologie und Intensivmedizin
  • Düsseldorf, Germany
    • Univerrsitätsklinikum Düsseldorf
  • Essen, Germany
    • Universitätsklinikum Essen
  • Frankfurt, Germany
    • Universitatsklinikum Frankfurt
  • Freiburg, Germany
    • University Hospital Freiburg - Department for Anesthesiology and Intensive Care Medicine
  • Gießen, Germany
    • Universitätsklinikum Giessen Klinik für Anaesthesiologie und operative Intensivmedizin
  • Greifswald, Germany
    • Universitätsklinikum Greifswald
  • Göttingen, Germany
    • Universitätsmedizin Göttingen Klinik für Anästhesiologie
  • Halle/Saale, Germany
    • Universitätsklinikum Halle
  • Heidelberg, Germany
    • University Hospital Heidelberg - Department for Anesthesiologie and Intensive Care Medicine
  • Homburg/Saar, Germany
    • Universitätsklinikum des Saarlandes
  • Köln, Germany
    • Klinikum der Universität Witten/Herdecke - Köln / Klinik für Anästhesiologie und operative Intensivmedizin
  • Leipzig, Germany
    • Universitätsklinikum Leipzig
  • Lübeck, Germany
    • UKSH Campus Lübeck - Department for Anesthesiology and Intensive Care Medicine
  • Magdeburg, Germany
    • University Hospital Magdeburg - Department for Anesthesiology and Intensive Care Medicine
  • Marburg, Germany
    • Universitätsklinikum Marburg
  • München, Germany
    • Technische Universität München
  • Ravensburg, Germany
    • Oberschwabenklinik Ravensburg Klinik für Anästhesie-, Intensiv-, Notfall- und Schmerzmedizin
  • Tübingen, Germany
    • University Hospital Tübingen - Department for Anesthesiology and Intensive Care Medicine
  • Ulm, Germany
    • Universitätsklinikum Ulm
  • Würzburg, Germany
    • Universitätsklinikum Würzburg Klinik und Poliklinik für Anästhesiologie, Intensivmedizin und Schmerztherapie

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Adults admitted for ICU therapy due to severe or critical Covid-19

Description

Inclusion Criteria:

• Age above 18 years
• Covid-19 disease (positive SARS-CoV-2 PCR)

Exclusion Criteria:

-none

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mortality	ICU Mortality of patients	up to 150 days

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
ICU length of stay	Intensive care unit length of stay	up to 150 days

Collaborators and Investigators

• Sponsor: University Hospital Tuebingen
• Investigators: Principal Investigator: Peter Rosenberger, MD, PhD, University Hospital Tübingen; Principal Investigator: Harry Magunia, MD, University Hospital Tübingen

Publications and helpful links

General Publications

• Magunia H, Lederer S, Verbuecheln R, Gilot BJ, Koeppen M, Haeberle HA, Mirakaj V, Hofmann P, Marx G, Bickenbach J, Nohe B, Lay M, Spies C, Edel A, Schiefenhovel F, Rahmel T, Putensen C, Sellmann T, Koch T, Brandenburger T, Kindgen-Milles D, Brenner T, Berger M, Zacharowski K, Adam E, Posch M, Moerer O, Scheer CS, Sedding D, Weigand MA, Fichtner F, Nau C, Pratsch F, Wiesmann T, Koch C, Schneider G, Lahmer T, Straub A, Meiser A, Weiss M, Jungwirth B, Wappler F, Meybohm P, Herrmann J, Malek N, Kohlbacher O, Biergans S, Rosenberger P. Machine learning identifies ICU outcome predictors in a multicenter COVID-19 cohort. Crit Care. 2021 Aug 17;25(1):295. doi: 10.1186/s13054-021-03720-4.

Helpful Links

• Study Landing Page

Study record dates

Study Major Dates

• Study Start (Actual): August 6, 2020
• Primary Completion (Actual): August 15, 2021
• Study Completion (Actual): September 30, 2021

Study Registration Dates

• First Submitted: July 1, 2020
• First Submitted That Met QC Criteria: July 1, 2020
• First Posted (Actual): July 2, 2020

Study Record Updates

• Last Update Posted (Actual): January 12, 2022
• Last Update Submitted That Met QC Criteria: January 11, 2022
• Last Verified: September 1, 2021

More Information

Terms related to this study

• Other Study ID Numbers: DCIR

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No