- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04550767
: Bacterial Infections in Injecting Drug Users
Bacterial Infections in People Who Inject Psychoactive Substances
Study Overview
Status
Conditions
Detailed Description
In context of an increase of bacterial infections in people who inject psychoactive substances (PS) all around the world and a lack of available scientific data, the investigators decided to set up a descriptive study on bacterial infection types and determinants in Injection Drug Users (IDUs).
Through a multidisciplinary approach between hospital departments (e.g. infectious diseases, emergency and addictology), the local addiction management and liaison team (ELSA) and the regional addictovigilance center, data were collected on appearance and course of bacterial infections in IDUs hospitalized at Montpellier University Hospital, France.
This study aims to provide medical data in order to better understand those infections and their determinants and provide information for potential future more specific observational studies.
The regional addictovigilance center is a member of the French Addictovigilance Network, which was established to monitor the potential for abuse and dependence of PS, and to provide information on the risk of addiction and advice for public health decision making, under the supervision of the French National Agency for Medicines and Health Products Safety. This surveillance system is principally based on spontaneous reporting by healthcare professionals and patients that is regulated by law. Collected data were extracted from those spontaneous reports (composed by data from the medical file*, DxCare or notification by medical team). First data were collected in 2012.
In addition, the investigators offered patients to fill in an anonymous questionnaire** on hygiene habits which was not mandatory and had no influence on treatment, and was offered during the ELSA team intervention (questions from the questionnaire are classical risk reduction question on injection and hygiene practices).
Main results are the description of the infections and injection practices. There is no control group per se as all included patients are IDUs and have a bacterial infection. But the investigators infection (such as abscess or skin and soft tissue) and those with a systemic infection. The two groups were established after the recruitment was completed. This comparative analysis is only performed in order to better understand the development of infections. Descriptive and comparative analyses was performed by the Department of Medical Information.
*Data collected :
- Age
- Sex
- Past history of bacterial infection linked to injection of a psychoactive substance
- HIV and HCV status
- Injected psychoactive substance
- Injection practices (frequency, route, location)
- Diagnosis
- Bacterial analysis
Treatments and course
- Hygiene questionnaire (attached file)
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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-
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Montpellier, France, 34290
- UHMontpellier
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-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion criteria:
- Bacterial infection occurring in injection drug users and linked to injection
- Hospitalized at Montpellier University Hospital
Exclusion criteria:
- No injection
- No use of a psychoactive substance
- Viral or fungal infection
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
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local infections
|
systemic infections
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Types of bacterial infections
Time Frame: 1 day
|
Types of bacterial infections : local or systemic:
|
1 day
|
Psychoactive substances involved in each type of bacterial infections
Time Frame: 1 day
|
Psychoactive substances involved in each type of bacterial infections
|
1 day
|
Types of injections in each type of infections
Time Frame: 1 day
|
Types of injections in each type of infections
|
1 day
|
Collaborators and Investigators
Sponsor
Investigators
- Study Director: Hélène Peyrière, PH, UH Montpellier
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- RECHMPL20_0523
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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