PET Perfusion Imaging Techniques and Comparing Them to CT Perfusion Imaging in Stroke

Developing PET Perfusion Imaging Techniques and Comparing Them to CT Perfusion Imaging in Stroke Patients

Adult patients who are diagnosed with an acute supratentorial ischemic stroke within 48 hrs of onset will be enrolled into the study. Participants will undergo both a CT Scan and PET scan within 7 days of onset. Participants will have the option to undergo a second PET scan with fluorodeoxyglucose (FDG).

Study Overview

• Status: Active, not recruiting
• Conditions: Acute Ischemic Stroke

Detailed Description

Patients older than 18 years of age diagnosed with an acute supratentorial ischemic stroke within 48 hrs of symptom onset will be prospectively enrolled. Research imaging will be obtained before 7 days after symptom onset. The patient will receive the standardized treatment protocol at the hospital. Informed consent will be obtained from each patient or a substitute decision maker for each individual imaging study (CTP, Rb PET, and FDG PET). The patient will be given the option of undergoing the CTP imaging with the Rb PET only or both the Rb PET and FDG PET components.

• Study Type: Observational
• Enrollment (Estimated): 20

Contacts and Locations

Study Locations

• Canada
  • Alberta
    • Edmonton, Alberta, Canada, T6G2B7
      • University of Alberta

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

Patients who are older than 18 years of age diagnosed with an acute supratentorial ischemic stroke within 48 hrs of onset will be enrolled into the study. Both male and female patients will be enrolled. We want diversity among participants in order to gain insightful information about acute supratentorial ischemic stroke as possible. A broad range in age, along with enrolling both male and female participants will allow greater diversity.

Description

Inclusion Criteria:

• Age: >18 yo
• Gender: male or female
• Acute (within 7 days from symptom onset) Supratentorial Ischemic Stroke

Exclusion Criteria:

• 1) Planned surgical intervention
• 2) Severely abnormal blood glucose level (will be excluded from FDG PET imaging)
• 3) Unable to undergo CTP or PET imaging (i.e. claustrophobia)
• 4) Pregnancy

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Compare PET brain perfusion imaging to CTP	Imaging of CTP images with the Rb PET only or both the Rb PET and FDG PET with CTP imaging components to evaluate blood flow and metabolism mismatches.	through study completion, 1 year from start of recruitment

Collaborators and Investigators

• Sponsor: University of Alberta
• Investigators: Principal Investigator: Brian Buck, Associate Professor

Study record dates

Study Major Dates

• Study Start (Actual): February 1, 2016
• Primary Completion (Estimated): December 31, 2024
• Study Completion (Estimated): December 31, 2025

Study Registration Dates

• First Submitted: May 19, 2020
• First Submitted That Met QC Criteria: September 25, 2020
• First Posted (Actual): September 30, 2020

Study Record Updates

• Last Update Posted (Actual): April 5, 2024
• Last Update Submitted That Met QC Criteria: April 3, 2024
• Last Verified: April 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Stroke; Ischemic Stroke
• Other Study ID Numbers: Version 1.0 28AUG2019

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No