Lung Diffusing Capacity for Nitric Oxide During Cycling Exercise

Test-retest Reliability of Lung Diffusing Capacity for Nitric Oxide During Light and Moderate Intensity Cycling Exercise

This study investigates the test-retest reliability of the lung diffusing capacity for nitric oxide in healthy individuals during exercise.

Study Overview

• Status: Completed
• Conditions: Healthy

Detailed Description

The aim of this study of to evaluate the test-retest reliability of single-breath lung diffusing capacity measurements for nitric oxide (DLNO) in healthy individuals during light and moderate intensity cycling exercise. Healthy subjects will perform repeated single-breath DLNO measurements during light (i.e., at 50% of the first ventilatory threshold) and moderate intensity exercise (i.e., 80% of the first ventilatory threshold) on a stationary cycle ergometer.

• Study Type: Observational
• Enrollment (Actual): 17

Contacts and Locations

Study Locations

• Switzerland
  • Zurich, Switzerland, 8001
    • University of Zurich and University Hospital of Zurich

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Healthy people without chronic cardiopulmonary diseases will be invited to participate in this study.

Description

Inclusion Criteria:

• Healthy
• Age 18 yrs and older
• Ability to follow study procedures and instructions in German

Exclusion Criteria:

• Any known cardiopulmonary or metabolic diseases (e.g., heart disease, diabetes mellitus etc)
• Obesity (BMI > 30kg/m2)
• Smoking (ex-smoker allowed; if they stopped smoking at least one year before the examination)
• Mental impairment leading to inability to cooperate
• Respiratory infection in the last two weeks
• Forced expiratory volume in 1s/ forced vital capacity (FEV1/FVC ratio) FEV1/FVC ratio < lower limit of normal according to equations by Quanjer et al. Eur Respir J 2012.

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Prospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Diffusing capacity for nitric oxide (DLNO)	DLNO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.	At second study visit
Diffusing capacity for nitric oxide (DLNO)	DLNO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.	At third study visit, approximately 1-2 weeks after second study visit

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Diffusing capacity for nitric oxide (DLNO)	DLNO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise.	At second study visit
Diffusing capacity for nitric oxide (DLNO)	DLNO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise.	At third study visit, approximately 1-2 weeks after second study visit
Diffusing capacity for carbon monoxide (DLCO)	DLCO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise.	At second study visit
Diffusing capacity for carbon monoxide (DLCO)	DLCO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise.	At third study visit, approximately 1-2 weeks after second study visit
Diffusing capacity for carbon monoxide (DLCO)	Agreement in DLCO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.	At second study visit
Diffusing capacity for carbon monoxide (DLCO)	Agreement in DLCO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.	At third study visit, approximately 1-2 weeks after second study visit
Alveolar volume (VA)	VA (in L) measured at 50% of the gas exchange threshold during cycling exercise.	At second study visit
Alveolar volume (VA)	VA (in L) measured at 50% of the gas exchange threshold during cycling exercise.	At third study visit, approximately 1-2 weeks after second study visit
Alveolar volume (VA)	Alveolar volume (in L) measured at 80% of the gas exchange threshold during cycling exercise.	At second study visit
Alveolar volume (VA)	Alveolar volume (in L) measured at 80% of the gas exchange threshold during cycling exercise.	At third study visit, approximately 1-2 weeks after second study visit
Breath hold time (BHT)	BHT (in s) measured at 80% of the gas exchange threshold during cycling exercise.	At second study visit
Breath hold time (BHT)	BHT (in s) measured at 80% of the gas exchange threshold during cycling exercise.	At third study visit, approximately 1-2 weeks after second study visit
Breath hold time (BHT)	BHT (in s) measured at 50% of the gas exchange threshold during cycling exercise.	At second study visit
Breath hold time (BHT)	BHT (in s) measured at 50% of the gas exchange threshold during cycling exercise.	At third study visit, approximately 1-2 weeks after second study visit

Collaborators and Investigators

• Sponsor: Thomas Radtke
• Investigators: Principal Investigator: Thomas Radtke, PhD, University of Zurich and University Hospital Zurich

Study record dates

Study Major Dates

• Study Start (Actual): October 19, 2020
• Primary Completion (Actual): December 31, 2020
• Study Completion (Actual): January 1, 2021

Study Registration Dates

• First Submitted: October 28, 2020
• First Submitted That Met QC Criteria: November 4, 2020
• First Posted (Actual): November 5, 2020

Study Record Updates

• Last Update Posted (Actual): April 19, 2021
• Last Update Submitted That Met QC Criteria: April 15, 2021
• Last Verified: April 1, 2021

More Information

Terms related to this study

• Keywords: lung function testing; lung diffusing capacity for nitric oxide
• Other Study ID Numbers: 2020-01756

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No