- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04829071
Cognition and Motor Learning Post-stroke
July 8, 2023 updated by: Kristan Leech, University of Southern California
Cognition as a Moderator of Motor Learning Post-stroke
This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship.
The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning.
Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.
Study Overview
Status
Recruiting
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Estimated)
65
Phase
- Early Phase 1
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Sarah Kettlety, MS
- Phone Number: (323) 442-1196
- Email: kettlety@usc.edu
Study Contact Backup
- Name: Kristan Leech, PT, DPT, PhD
- Phone Number: (323) 442-1583
- Email: kleech@pt.usc.edu
Study Locations
-
-
California
-
Los Angeles, California, United States, 90033
- Recruiting
- Center for Health Professions
-
Contact:
- Kristan Leech, PT, DPT, PhD
- Phone Number: 312-442-1583
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-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
45 years to 85 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Description
Inclusion Criteria:
- Unilateral stroke
- Stroke occurred more than 6 months prior
- Paresis confined to one side
- Independently ambulatory (including the use of assistive devices)
- Able to walk for 5 minutes without stopping
- Answers no to all general health questions on the PAR-Q+
- Willingness to complete study procedures
Exclusion Criteria:
- Brainstem or cerebellar stroke
- Aphasia (expressive, receptive, or global)
- Any major musculoskeletal or non-stroke neurological condition that interferes with the assessment of sensorimotor or cognitive function
- Metal in the head (except in the mouth), implanted cranial or thoracic devices that violate MRI safety regulations
- Uncontrolled hypertension (>160/110mmHg)
- Concurrent physical therapy
- Claustrophobia
- Significant cognitive deficit or dementia (<20 on MoCA)
- Inability to give informed consent
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Evaluating motor learning and brain structures post-stroke
We will use a single arm design to determine the impact of post-stroke cognitive impairment on two forms of motor learning (implicit and explicit) and evaluate the structural integrity of relevant brain structures in 65 individuals post stroke
|
Participants will be provided with visual feedback of their right and left step lengths on a screen in front of a treadmill.
Participants will walk on a treadmill that drives their right and left legs to move at two different speeds.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
step length asymmetry - change in performance
Time Frame: Measured at three timepoints of interest within each testing session: baseline and at the beginning and end of the interventions; participants will complete 2 testing sessions over approximately 1 months
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characterized as a comparison between the right and left step lengths; captured to quantify change in performance with biofeedback or split belt walking
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Measured at three timepoints of interest within each testing session: baseline and at the beginning and end of the interventions; participants will complete 2 testing sessions over approximately 1 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
step length asymmetry - immediate retention
Time Frame: Measured after motor learning in each testing session; participants will complete 2 testing sessions over approximately 1 months
|
characterized as a comparison between the right and left step lengths; captured to quantify the retention of a newly learned walking pattern
|
Measured after motor learning in each testing session; participants will complete 2 testing sessions over approximately 1 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Kristan Leech, PT, DPT, PhD, University of Southern California
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 16, 2023
Primary Completion (Estimated)
August 14, 2025
Study Completion (Estimated)
August 14, 2025
Study Registration Dates
First Submitted
March 30, 2021
First Submitted That Met QC Criteria
March 30, 2021
First Posted (Actual)
April 2, 2021
Study Record Updates
Last Update Posted (Actual)
July 11, 2023
Last Update Submitted That Met QC Criteria
July 8, 2023
Last Verified
July 1, 2023
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- APP-21-00898
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
YES
IPD Plan Description
All de-identified data from our research that underlie results in a publication will be made available on the Open Science Framework.
IPD Sharing Time Frame
data will be made available 6 months after publication
IPD Sharing Supporting Information Type
- ANALYTIC_CODE
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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