Identification Of Occupational Exposures In Patients With ILD (ILD)

Identification of Occupational Exposures in Patients With Interstitial Lung Diseases (ILD)

Diffuse interstitial lung disease brings together a heterogeneous group of pulmonary pathologies, characterized by infiltrating and diffuse lesions of the pulmonary interstitium. The evolving risk of these ILD is pulmonary fibrosis, with the development of chronic respiratory failure.

The process of the etiological diagnosis of ILD results from a multidisciplinary approach (pulmonologists, radiologists, occupational health specialists, anatomo-pathologists, etc…). Indeed, the multitude of possible causes of these diseases makes the etiological diagnosis difficult. Professional aetiologies are also frequently mentioned : pneumoconiosis, hypersensitivity pneumonitis, as a differential diagnosis.

It therefore appears essential to deepen the professional aspect during the diagnostic process for ILD.

Since May 2020, a professional interview has been systematically offered by the Occupational Pathology Consultation Center of the Hospital Center Lyon Sud, to patients followed by the team of Professor Vincent COTTIN, whose file was discussed in a multidisciplinary meeting.

The data collected to constitute a database are the following variables: age, sex, diploma, professional course coded in CITP (International Standard Classification of Professions) and NAF (French Nomenclature of Activities), occupational exposures, smoking, risk factors non-professionals, clinical elements of ILD and elements relating to an occupational disease certificate. This database is anonymized.

Study Overview

• Status: Completed
• Conditions: Interstitial Lung Disease; Occupational Exposure
• Intervention / Treatment: Other: Professional course, occupational exposures

• Study Type: Observational
• Enrollment (Actual): 150

Contacts and Locations

Study Locations

• France
  • Pierre-Bénite, France, 69310
    • Centre de consultation de pathologie professionnelle, Centre Hospitalier Lyon Sud

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients with ILD

Description

Inclusion Criteria:

• Patients with ILD.
• File discussed in a multidisciplinary meeting since May 2020 at the Louis Pradel Pneumological Hospital.
• Have benefited from a professional interview in the Occupational pathology consultation center of the Hospital Center Lyon Sud.

Exclusion Criteria:

• Patients with sarcoidosis.

Study Plan

How is the study designed?

Design Details

• Observational Models: Case-Only
• Time Perspectives: Retrospective

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort

Intervention / Treatment

ILD; Patients with ILD, whose file has been discussed in a multidisciplinary meeting since May 2020 at the Louis Pradel Pneumological Hospital, and who have benefited from a professional interview in the Occupational pathology consultation center of the Hospital Center Lyon Sud.

Other: Professional course, occupational exposures; The data collected are the following variables: age, sex, diploma, professional course coded in CITP (International Standard Classification of Professions) and NAF (French Nomenclature of Activities), occupational exposures, smoking, risk factors non-professionals, clinical elements of ILD and elements relating to an occupational disease certificate. This database is anonymized. The precise diagnosis of ILD is retained during the multidisiciplinary meeting. Occupational exposures are assessed in specialized consultation : a first professional interview phase: The professional history is traced, listing the training courses followed and the trades carried out. The questioning is precise and focuses on the different tasks performed, and the products used.; a second step, where a questionnaire is completed by the doctor: A list of specific substances is offered to the patient, who responds whether or not he thinks he has been exposed to them in his professional past.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Study the distribution of occupational exposures according to the types of ILD. The precise diagnosis is retained during the multidisiciplinary meeting.	Precise diagnosis of ILD : type of PID diagnosed	The precise diagnosis of ILD is retained immediately after the multidisiciplinary meeting.
Occupational exposures are assessed in specialized consultation by the occupational physician.	Occupational exposures	Occupational exposures are assessed immediately after the occupational consultation.

Collaborators and Investigators

• Sponsor: Hospices Civils de Lyon

Study record dates

Study Major Dates

• Study Start (Actual): May 15, 2020
• Primary Completion (Actual): March 15, 2021
• Study Completion (Actual): April 15, 2021

Study Registration Dates

• First Submitted: March 26, 2021
• First Submitted That Met QC Criteria: May 4, 2021
• First Posted (Actual): May 10, 2021

Study Record Updates

• Last Update Posted (Actual): May 10, 2021
• Last Update Submitted That Met QC Criteria: May 4, 2021
• Last Verified: March 1, 2021

More Information

Terms related to this study

• Keywords: Pulmonary Fibrosis; Interstitial Lung Disease; Occupational Exposure; Lung Fibrosis
• Additional Relevant MeSH Terms: Respiratory Tract Diseases; Lung Diseases; Lung Diseases, Interstitial
• Other Study ID Numbers: A257

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No