Assessment of Eyelid Topology and Kinetics Based on Deep Learning Method

June 8, 2021 updated by: Second Affiliated Hospital, School of Medicine, Zhejiang University

Department of Ophthalmology

This study plans to assess eyelid topology (such as margin reflex distance, eyelid contour, and corneal exposure area) and blinking (such as frequency, velocity, and duration), using deep learning method to automatically extract eyelid topological features, and to predict subtypes of levator function, using deep learning method to extract blinking features, in order to provide new ideas and means to assess eyelid topology and kinetics.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Anticipated)

500

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • China
    • Zhejiang
      • Hangzhou, Zhejiang, China, 310000
        • Recruiting
        • Juan Ye
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

100 normal volunteers without eyelid diseases 100 patients with blepharoptosis 100 patients with blepharospasm 100 patients with dry eye disease 100 patients with Graves' disease

Description

Inclusion Criteria:

  1. normal volunteers without eyelid diseases
  2. patients with blepharoptosis
  3. patients with blepharospasm
  4. patients with dry eye disease
  5. patients with Graves' disease

Exclusion Criteria:

variable ptosis (e.g., myasthenia gravis), entropion, ectropion, enophthalmos, exophthalmos, strabismus, and abnormalities of pupil

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Other
  • Time Perspectives: Cross-Sectional

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Normal participants
Other: Photography
Facial photographs and blinking videos are taken
Patients with blepharoptosis
Other: Photography
Facial photographs and blinking videos are taken
Patients with blepharospasm
Other: Photography
Facial photographs and blinking videos are taken
Patients with dry eye disease
Other: Photography
Facial photographs and blinking videos are taken
Patients with Graves' disease
Other: Photography
Facial photographs and blinking videos are taken

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
one-dimensional parameters of eyelid topology
Time Frame: through study completion, 5 years
Palpebral fissure length [Margin reflex distance 1, Margin reflex distance 2], Lid length [Upper lid length, Lower lid length], Multiple mid-pupil lid distances
through study completion, 5 years
two-dimensional parameters of eyelid topology
Time Frame: through study completion, 5 years
Palpebral fissure area [Medial area, Corneal area, Lateral area]
through study completion, 5 years
subtypes of levator function
Time Frame: through study completion, 5 years
Levator function is classified into three categories: good, fair and poor
through study completion, 5 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

August 1, 2020

Primary Completion (Anticipated)

August 1, 2025

Study Completion (Anticipated)

August 1, 2026

Study Registration Dates

First Submitted

June 1, 2021

First Submitted That Met QC Criteria

June 8, 2021

First Posted (Actual)

June 10, 2021

Study Record Updates

Last Update Posted (Actual)

June 10, 2021

Last Update Submitted That Met QC Criteria

June 8, 2021

Last Verified

June 1, 2021

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2020-485

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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