INCIDENCE OF Delirium After Cardiac SURGERY Surgery

Incidence And Predictors of Delirium After Cardiac Surgery; A Prospective Observational Cohort Study From a Single Tertiary Referral Centre

Delirium is a common problem that occurs after cardiac surgery. The incidence of delirium after cardiac surgery is estimated to be 26-52%, with a significant percentage being hypoactive delirium1-4.Postoperative delirium has been associated with higher hospital costs, longer lengths of hospital stay, increased likelihood of institutionalization, increased risk for dementia, and increased morbidity and mortality.5-7 .

The overall purpose of this study was to determine the incidence and perioperative factors that predispose to cause delirium in postoperative cardiac surgery patients in our ICU

Study Overview

• Status: Completed
• Conditions: Delirium

• Study Type: Observational
• Enrollment (Actual): 234

Contacts and Locations

Study Locations

• Nepal
  • Kathmandu, Nepal, 11360
    • Shahid Gangalal National Heart Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients 18 years old and older of both sexes who are undergoing cardiac surgery in a single centre

Description

Inclusion Criteria:

• Patients 18 years old and older of both sexes
• Patients who signed an informed consent
• Patients scheduled for cardiac surgery with extracorporeal circulation (coronary-artery bypass grafting (CABG), cardiac valve replacement (CVR), combined CABG + CVR, excision of cardiac myxoma)

Exclusion Criteria:

• Patients who refused to participate before or after operation;
• Patients in poor general condition;
• Patients with preoperative dementia, delirium or illiterate, psychiatric or mental disorder (epilepsy, schizophrenia, depression);
• Patients who died intraoperatively or within the first 6 hours after the procedure.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Without delirium
With delirium

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
incidence and perioperative factors that predispose to cause delirium in postoperative cardiac surgery patients in our ICU	Incidence and perioperative risk factors that may predispose to delirium after cardiac surgery in our settings	6 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
ICU stay and mechanical ventilation time	whetherICU stay in days and mechanical ventilation time in number of hours is affected by delirium	6 months

Collaborators and Investigators

• Sponsor: Shahid Gangalal National Heart Centre

Study record dates

Study Major Dates

• Study Start (ACTUAL): July 1, 2018
• Primary Completion (ACTUAL): December 30, 2018
• Study Completion (ACTUAL): December 30, 2018

Study Registration Dates

• First Submitted: July 12, 2021
• First Submitted That Met QC Criteria: July 22, 2021
• First Posted (ACTUAL): August 2, 2021

Study Record Updates

• Last Update Posted (ACTUAL): August 2, 2021
• Last Update Submitted That Met QC Criteria: July 22, 2021
• Last Verified: July 1, 2021

More Information

Terms related to this study

• Keywords: delirium;post-cardiac surgery;adults
• Additional Relevant MeSH Terms: Mental Disorders; Nervous System Diseases; Neurologic Manifestations; Confusion; Neurobehavioral Manifestations; Neurocognitive Disorders; Delirium
• Other Study ID Numbers: SGNHC 2

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No