Two Cases of Pulmonary Cysticercosis Manifesting as Pleural Effusion: Case Report and Literature Review

Isolation lung cysticercosis reports are rare in literature. Most lung lesions were characterized by nodules. The investigators access one case which was characterized with pulmonary cavity and pleural effusion by Gupta N, et al in 2015 from PUBMED and Medline. But pleural effusion and exudative lesions is reported for the first time.

Study Overview

• Status: Completed
• Conditions: Cysticercosis

Detailed Description

Cysticercosis is an important public health problem in developing countries. The major involvement sites are the central nervous system and the eyes，although striated muscles and subcutaneous tissues are frequently involved in the disseminated form of disease. Pulmonary involvement in cysticercosis is very rare and ill-defined nodular shadows distributed throughout the lung is the usual radiological presentation. Only one case of cysticercosis presenting as lung cavity with pleural effusion has been reported so far in literature. The investigators describe two cases in which pleural effusion due to cysticercosis were detected on X and CT.

• Study Type: Observational
• Enrollment (Actual): 2

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 45 years to 67 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Two patients with pleural effusion presenting with chest tightness and chest pain were enrolled in this study with a definitive diagnosis of cysticercosis confirmed by pleural effusion examination

Description

Inclusion Criteria:

1. Clinical diagnosis of Pulmonary Cysticercosis。
2. With pleural effusion

Exclusion Criteria:

1.No cysticercosis was found by biopsy or antibody test

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Amount of pleural effusion	cm	9 months
Rate of Eosinophil ratio	Percentage（%）	9 months
Changes of lesions under chest radiography or CT	no change, change, complete absorption	9 months

Collaborators and Investigators

• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
• Investigators: Study Director: Pingli Wang, MD, the same research center

Study record dates

Study Major Dates

• Study Start (ACTUAL): October 22, 2016
• Primary Completion (ACTUAL): January 18, 2017
• Study Completion (ACTUAL): April 28, 2017

Study Registration Dates

• First Submitted: July 11, 2021
• First Submitted That Met QC Criteria: August 15, 2021
• First Posted (ACTUAL): August 18, 2021

Study Record Updates

• Last Update Posted (ACTUAL): August 30, 2021
• Last Update Submitted That Met QC Criteria: August 24, 2021
• Last Verified: September 1, 2016

More Information

Terms related to this study

• Keywords: pleural effusion; Cysticercosis; pulmonary
• Additional Relevant MeSH Terms: Central Nervous System Diseases; Nervous System Diseases; Infections; Respiratory Tract Diseases; Pleural Diseases; Central Nervous System Infections; Parasitic Diseases; Helminthiasis; Cestode Infections; Central Nervous System Helminthiasis; Central Nervous System Parasitic Infections; Pleural Effusion; Cysticercosis; Taeniasis; Neurocysticercosis
• Other Study ID Numbers: 2016-122

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No