- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05086484
Omics Sequencing of Specimen Derived From Patients With Endometriosis
October 20, 2021 updated by: Zhujiang Hospital
Endometriosis is a type of chronic inflammatory gynecological disease, mainly took place in peritoneal cavity.
In order to investigate the possible correlation between microbes and endometriosis, the investigators planed to perform 16S rDNA amplicon sequencing, metagenomic sequencing and metabolomic sequencing of paired samples derived from feces, cervical mucus, blood and peritoneal fluid.
Study Overview
Status
Recruiting
Conditions
Study Type
Observational
Enrollment (Anticipated)
1000
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Ying Ma, PhD
- Phone Number: 13113361169
- Email: mayingwuzhuoyi@126.com
Study Contact Backup
- Name: Liujing Huang, Bachelor
- Phone Number: 15916388839
- Email: 15916388839@163.com
Study Locations
-
-
Guangdong
-
Guangzhou, Guangdong, China
- Recruiting
- Zhujiang Hospital
-
Contact:
- Ying Ma, PhD
- Phone Number: 13113361169
- Email: mayingwuzhuoyi@126.com
-
Contact:
- Liujing Huang, Bachelor
- Phone Number: 15916388839
- Email: 15916388839@163.com
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 52 years (Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
Female
Sampling Method
Probability Sample
Study Population
Study population are those who are admitted to Zhujiang Hospital of Southern Medical University in Guangzhou, China, due to gynecological diseases.
At least two gynecologists independently screened and assessed the condition of the participants strictly according to the inclusion and exclusion criteria
Description
Inclusion Criteria:
- The subject who is female.
- The subject who is infertility or sub-fertile.
- The subject whose age was between 18-52 years old.
- The subject who is suspected to have endometrioma.
- The subject whose menstrual cycle length is between 28-35 days.
- The subject without the history of abdominal or pelvic surgery.
- The subject who has dysmenorrhea.
- The subject who has dispareunia.
- The subject who was informed the risks and benefits of the experiment and provided written informed consent, and gave their approval.
- The subject who has chronic pelvic pain and the pain get worse during periods.
- The subject who has no sexual activity within a week.
- The subject who has no history of acute or chronic pelvic inflammatory disease.
- The subject who has confirmed EM with biopsy.
- The subject without hormonotherapy within 6 months.
- The subject without medical history of antibiotics within 6 months.
Exclusion Criteria:
- The subject who has hernia.
- The subject who is pregnant.
- The subject who has malignant tumor.
- The subject who has Gene Therapy history.
- The subject who has abdominal or pelvic surgery history.
- The subject who has peritonitis.
- The subject who is below 18 years old or over 52 years old.
- The subject who can not endure laparoscopy.
- The subject who has cardiovascular disease.
- The subject who has systemic or regional acute inflammation.
- The subject who has chronic liver or kidney disease.
- The subject whoes body mass index ≤ 18.5 or ≥ 28 (kg m-2).
- The subject who has coagulation defects or hematologic diseases.
- The subject who has tuberculosis or chronic obstructive pulmonary disease.
- The subject whoes alcohol consumption ≥ 60 g d-1, or smokers (≥20 cigarettes d-1).
- The subject who has hypertension, diabetes, hyperthyroidism and ect.
- The subject whoes medical history of transfusion, stem cell or bone marrow transplantation.
- The subject who has contraindication of tracheal intubation anesthesia.
- The subject who received hormonotherapy within 6 months.
- The subject who has immunodeficient, allergic or autoimmune diseases.
- The subject who used antibiotics within 6 months.
- The subject who is drug abuse.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
---|
Endometriosis group
Women diagnosed with endometriosis.
|
Control group
Women diagnosed without endometriosis.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
16s amplicon sequencing
Time Frame: 2019/01/01-2023/12/31
|
Compare the microbiota composition differences of specimens derived from control group and Endometriosis group.
|
2019/01/01-2023/12/31
|
metatranscriptomic sequencing
Time Frame: 2019/01/01-2023/12/31
|
Compare the RNA concentration differences of specimens derived from control group and Endometriosis group.
|
2019/01/01-2023/12/31
|
metabolomic sequencing
Time Frame: 2019/01/01-2023/12/31
|
Compare the metabolites concentration differences of specimens derived from control group and Endometriosis group.
|
2019/01/01-2023/12/31
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 1, 2019
Primary Completion (Anticipated)
December 31, 2023
Study Completion (Anticipated)
December 31, 2025
Study Registration Dates
First Submitted
October 1, 2021
First Submitted That Met QC Criteria
October 20, 2021
First Posted (Actual)
October 21, 2021
Study Record Updates
Last Update Posted (Actual)
October 21, 2021
Last Update Submitted That Met QC Criteria
October 20, 2021
Last Verified
October 1, 2021
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- ZhujiangHfck
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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