Pulse Wave Velocity and Hemodynamic Response During Anesthesia Induction in Hypertensive Patients (AS)

Comparison of the Relationship Between Preoperatively Measured Pulse Wave Velocity and Hemodynamic Changes During Anesthesia Induction in Hypertensive and Normotensive Patients.

Hypertension is a disease with increasing and serious complications all over the world. In particular, the incidence of hypertension increases with advancing age. Secondary problems that can be caused by hypertension include peripheral vascular diseases, arteriosclerosis, increased risk of heart attack and stroke. It is a measurement of pulse wave velocity (PWV), a non-invasive indicator of arterial stiffness. It is known that sudden hemodynamic changes that occur during the induction of anesthesia cause undesirable intraoperative and postoperative complications. It is known that arterial stiffness, which is more common in elderly patients, causes orthostatic hypotension in particular. For this reason, more hemodynamic instability may be seen in the general anesthesia procedure in elderly patients with increased arterial stiffness.

In our study, we aimed to investigate whether the hemodynamic changes observed during anesthesia induction in hypertensive elderly patients, whom we think have a high pulse wave velocity, are different from normotensive patients.

Study Overview

• Status: Completed
• Conditions: Arterial Stiffness
• Intervention / Treatment: Procedure: Mobil-O-Graph PWA

• Study Type: Observational
• Enrollment (Actual): 139

Contacts and Locations

Study Locations

• Turkey
  • Aydın, Turkey, 09100
    • Aydın Adnan Menderes University Faculty of Medicine, Department of Anesthesiology and Reanimation

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 50 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

All Patients aged 50 and over

Description

Inclusion Criteria:

• According to the American Society of Anesthesiologists (ASA), physical condition I-II,
• Elective otolaryngology surgery with endotracheal intubation planned
• Patients aged 50 and over

Exclusion Criteria:

• Hypersensitivity to drugs
• Difficult intubation history
• Diabetes mellitus receiving insulin therapy
• Chronic renal failure or end-stage renal disease
• Heart failure (left ventricular ejection fraction ≤30%)
• Valve disease (moderate to severe)
• Atrial fibrillation

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Group H; Hypertension group (Group H): Patients with a previous diagnosis of hypertension; Patients receiving antihypertensive therapy; Systolic blood pressure (SBP) ≥140mmHg and/or diastolic blood pressure (DBP) ≥90mmHg	Procedure: Mobil-O-Graph PWA; After resting in a quiet room preoperatively, blood pressure was measured on the right arm using an oscillometric method.
Group N; Normotensive group (Group N): Other non-hypertensive patients	Procedure: Mobil-O-Graph PWA; After resting in a quiet room preoperatively, blood pressure was measured on the right arm using an oscillometric method.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Difference between hemodynamic values	The difference between the hemodynamic values measured preoperatively and during anesthesia induction was calculated. In addition, ≥20% decrease in preoperative hemodynamic value and/or systolic blood pressure ≤90 mmHg hypotension, ≥20% increased hypertension	Basal measurement before induction of anesthesia, then at 1-minute intervals until after endotracheal intubation

Collaborators and Investigators

• Sponsor: Aydin Adnan Menderes University

Study record dates

Study Major Dates

• Study Start (Actual): November 1, 2018
• Primary Completion (Actual): November 1, 2019
• Study Completion (Actual): November 1, 2020

Study Registration Dates

• First Submitted: December 3, 2021
• First Submitted That Met QC Criteria: December 3, 2021
• First Posted (Actual): December 13, 2021

Study Record Updates

• Last Update Posted (Actual): December 13, 2021
• Last Update Submitted That Met QC Criteria: December 3, 2021
• Last Verified: December 1, 2021

More Information

Terms related to this study

• Other Study ID Numbers: Arterial stiffness

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No