Influencing Factors of Coronary Heart Disease in Young People

July 23, 2023 updated by: Hongzhuan Sheng

To Study the Risk Factors of Youth Coronary Heart Disease From Inflammatory Cytokines，Lifestyle and Familial Inheritance

The incidence of coronary heart disease in young people is not uncommon and the investigators will explore the factors contributing to this outcome

Study Overview

Status

Recruiting

Conditions

Detailed Description

Through the multi-center clinical research conducted by several units in Nantong city, the risk factors and aggregation of the incidence of CHD among young people in nantong city were obtained, so as to fill in the blank of domestic multi-center research and reduce the incidence of CHD among young people.The investigators will conduct a long-term follow-up study on the young patients with CHD to screen the factors contributing to the poor prognosis of CHD in young patients.The investigators will fill this gap and intervene early to improve patients' quality of life and prolong their survival

Study Type

Observational

Enrollment (Estimated)

1000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

  • Name: H L, A master's degree
  • Phone Number: 18351328050
  • Email: 898571711@qq.com

Study Locations

  • China
    • Jiangsu
      • Nantong, Jiangsu, China, 226000
        • Recruiting
        • shengHz
        • Contact:
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 45 years (Adult)

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Diagnosed coronary heart disease

Description

Inclusion Criteria:

  • Diagnosed coronary heart disease
  • Confirmed by coronary angiography
  • Diagnosed myocardial infarction
  • Willing to sign an inform consent

Exclusion Criteria:

  • Patients won't sign an inform consent or will not comply with the follow up.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Normal young
Aged less than 45 years old,no underlying heart disease
Young people diagnosed with coronary heart disease
Aged less than 45 years old,Diagnosed coronary heart disease;Confirmed by coronary angiography;Diagnosed myocardial infarction;Typical symptom of ischemic chest pain with positive stress test;
Coronary heart disease
Older than 65 years, diagnosed with coronary heart disease

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Whether inflammatory factors are differentially expressed in young patients with coronary heart disease
Time Frame: Until April 2024
The Investigators will analyze blood samples from the participants to see if there was a difference in the expression of inflammatory factors with high correlation compared with the control group by ELESA and High-throughput sequencing.
Until April 2024
The effect of gene activity on youth morbidity
Time Frame: Until April 2024
The investigators will use enrichment analysis to screen the target genes and sequence the participants.Whether the target gene was expressed at high levels in the participants.And the investigators will further analyze the target gene
Until April 2024
Sedentary, high-fat diet, lack of exercise and other unhealthy lifestyle effects on young people
Time Frame: Until April 2024
The researchers will retrospectively examine the participants' negative lifestyle habits, such as sedentary behavior, smoking, high-fat diet, and lack of exercise, in combination with their coronary angiography results
Until April 2024

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Hongzhuan Sheng

Collaborators

Affiliated Hospital of Nantong University

Investigators

  • Study Chair: hzh sheng, Dr., Affiliated Hospital of Nantong University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

August 1, 2021

Primary Completion (Estimated)

August 1, 2024

Study Completion (Estimated)

August 1, 2024

Study Registration Dates

First Submitted

November 5, 2021

First Submitted That Met QC Criteria

December 27, 2021

First Posted (Actual)

January 3, 2022

Study Record Updates

Last Update Posted (Actual)

July 25, 2023

Last Update Submitted That Met QC Criteria

July 23, 2023

Last Verified

July 1, 2023

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Observational

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

We will share our findings with you when the 2024 project is due

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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