Management and Outcome of Fever in Children in Europe (MOFICHE)

Personalised Risk Assessment in Febrile Illness to Optimise Real-life Management Across the European Union (PERFORM)

This is an observational study assessing the management and outcome of children presenting to Emergency Departments (ED) with fever across Europe.

Study Overview

• Status: Completed
• Conditions: Antibiotic Prescription
• Intervention / Treatment: Other: antibiotic prescription

Detailed Description

This is an observational study assessing the management and outcome of children presenting to Emergency Departments (ED) with fever across Europe. This study will use large departmental datasets to collect information on at least 50,000 febrile episodes . This study will use large-scale, pseudo-anonymized departmental data, and will not involve consented patient recruitment; nor will it use patient samples. Data included in MOFICHE will be based on that collected as part of routine clinical care. Antibiotic prescription, hospitalisation and number/type of investigations, re-attendance at ED within 5 days of the first hospital presentation will be recorded.

• Study Type: Observational
• Enrollment (Actual): 38480

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: No older than 18 years (ADULT, CHILD)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Febrile children aged 0- 18 years visiting the emergency care.

Description

Inclusion Criteria:

• aged 0- 18 years visiting the emergency care.
• fever measured at ED or history of (measured) fever less than 3 consecutive days prior to presentation at emergency department

Exclusion Criteria:

-

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Antibiotic prescription	number of antibiotic prescriptions	one year
hospitalization	number of children requiring admission to hospital	one year
Number of investigations	number of investigations	one year
Number of children re-attending within 5 days of the first hospital presentation.	Number of re-attendance	one year

Collaborators and Investigators

• Sponsor: Imperial College London

Study record dates

Study Major Dates

• Study Start (ACTUAL): January 1, 2017
• Primary Completion (ACTUAL): April 1, 2018
• Study Completion (ACTUAL): December 31, 2021

Study Registration Dates

• First Submitted: January 18, 2022
• First Submitted That Met QC Criteria: February 2, 2022
• First Posted (ACTUAL): February 3, 2022

Study Record Updates

• Last Update Posted (ACTUAL): February 3, 2022
• Last Update Submitted That Met QC Criteria: February 2, 2022
• Last Verified: January 1, 2022

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Anti-Infective Agents; Anti-Bacterial Agents
• Other Study ID Numbers: REC ref: 16/LO/1684-S

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No