The Observation About the Effects of Internal Carotid Artery Stenosis on Fundus Vessels and the Changes of Fundus Vessels After Interventional Therapy

The investigators plan to collect 30 participants with internal carotid artery stenosis to observed the relationship between the degree of internal carotid artery stenosis and fundus vessels （and blood flow）density before operation, and compared with participants without internal carotid artery stenosis.The fundus blood flow density will be observed after intervention operation in order to see whether the operation is effective to improve the density of fundus vessels and blood flow or not.

Study Overview

• Status: Recruiting
• Conditions: Internal Carotid Artery Stenosis

• Study Type: Observational
• Enrollment (Anticipated): 30

Contacts and Locations

• Study Contact: Name: Yan Cui, doctor; Phone Number: （+86）18560088136; Email: cyeleanor@163.com

Study Locations

• China
  • Shandong
    • Jinan, Shandong, China, 250012
      • Recruiting
      • Department of ophthalmology and neurology at Qilu Hospital of Shandong University
      • Contact: Xuepeng Yang, undergrad; Phone Number: （+86）15628762662; Email: 2420930410@qq.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 45 years to 80 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients who have been diagnosed with carotid artery stenosis and need surgery.

Description

Inclusion Criteria:

1. Patients who have been diagnosed with carotid artery stenosis and need surgery;
2. Patients whose vision won't get worse soon;
3. Patients have not had any eye surgeries;
4. Patients with complete profile.

Exclusion Criteria:

1. Patients with severe systemic disease;
2. Patients with poor dioptric stroma;
3. Patients with nystagmus;
4. Patients with incomplete profile.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The differences of perfusion density in the Forum of the optical coherence tomography angiography（OCTA ）of Zeiss Company	The perfusion density differences between the fundus vessels（both the macula area and the optic disc area） on the carotid artery stenosis side and the not-significant narrowing side，or the perfusion density differences between the fundus vessels（both the macula area and the optic disc area） on the carotid artery stenosis side and the side with carotid artery stenosis of different degrees.	2022-01-31
The differences of perfusion density in the Forum of the optical coherence tomography angiography（OCTA ）of Zeiss Company	The perfusion density differences between the fundus vessels on the carotid artery stenosis side and the same side after interventional surgery.	2022-02-14
The differences of vessel density in the Forum of the optical coherence tomography angiography（OCTA ）of Zeiss Company	The vessel density differences between the fundus vessels（both the macula area and the optic disc area） on the carotid artery stenosis side and the not-significant narrowing side，or the vessel density differences between the fundus vessels（both the macula area and the optic disc area） on the carotid artery stenosis side and the side with carotid artery stenosis of different degrees.	2022-01-31
The differences of vessel density in the Forum of the optical coherence tomography angiography（OCTA ）of Zeiss Company	The vessel density differences between the fundus vessels on the carotid artery stenosis side and the same side after interventional surgery.	2022-02-14
The perimeter and area of the fovea avascular zone（FAZ）in the Forum of the optical coherence tomography angiography（OCTA ）of Zeiss Company	The differences between the perimeter and area of the fovea avascular zone（FAZ） of the carotid artery stenosis side before and after interventional surgery.	2022-02-14

Collaborators and Investigators

• Sponsor: Qilu Hospital of Shandong University

Study record dates

Study Major Dates

• Study Start (ACTUAL): December 12, 2021
• Primary Completion (ANTICIPATED): April 30, 2022
• Study Completion (ANTICIPATED): May 31, 2022

Study Registration Dates

• First Submitted: February 14, 2022
• First Submitted That Met QC Criteria: February 24, 2022
• First Posted (ACTUAL): March 2, 2022

Study Record Updates

• Last Update Posted (ACTUAL): March 2, 2022
• Last Update Submitted That Met QC Criteria: February 24, 2022
• Last Verified: October 1, 2021

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Arterial Occlusive Diseases; Pathological Conditions, Anatomical; Carotid Artery Diseases; Carotid Stenosis; Constriction, Pathologic
• Other Study ID Numbers: cuiyanqiluteam

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No