Anti-Plaque and Anti-Gingivitis Effects of Moringa Plant Extract and Fluoride Toothpastes

Evaluation of the Anti-Plaque and Anti-Gingivitis Effects of Moringa Plant Extract and Fluoride Toothpastes Among a Group of Egyptian Children: A Randomized Clinical Trial

The present study aims to assess and compare the anti-plaque and anti-gingivitis effects of Moringa plant extract and Fluoride toothpastes among a group of Egyptian Children.

Study Overview

• Status: Recruiting
• Conditions: Oral Disease
• Intervention / Treatment: Drug: Moringa oleifera leaf

Detailed Description

In the last few years, the use of plant extracts in alternative medicine has evolved widely. Various herbal products, including mouthwash and toothpaste, are now available and have been shown to possess a beneficial effect on oral health .Moringa plant is used to treat various diseases including the treatment of the oral cavity or dentistry .

• Study Type: Interventional
• Enrollment (Anticipated): 60
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: marwa A elchaghaby, phd; Phone Number: 01006231612; Email: marwaaly2003@yahoo.com

Study Locations

• Egypt
  • Giza, Egypt
    • Recruiting
    • Cairo University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 12 years to 14 years (Child)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Children of 12-14 years of age.
• Presence of gingivitis-calculus, and plaque (gingival index [GI]score ≥1/plaque index [PI] score ≥1).
• Children willing to participate.
• Children whose parents/caretakers gave informed consent.

Exclusion criteria

• Children having fixed or removable orthodontic appliances or removable prostheses.
• Children suffering from any systemic illness.
• Children who were already using mouthwashes.
• History of oral prophylaxis within 6 months.
• Children using any other oral hygiene aids.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Fluoride toothpaste	Drug: Moringa oleifera leaf; Moringa toothpaste
Experimental: moringa plant toothpaste	Drug: Moringa oleifera leaf; Moringa toothpaste

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
gingival index (Loe and Sillness, 1963)	index	6 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
plaque index (Sillness and Loe, 1964)	index	6 weeks

Collaborators and Investigators

• Sponsor: Cairo University
• Investigators: Principal Investigator: marwa m elchaghaby, phd, marwaaly2003@yahoo.com

Study record dates

Study Major Dates

• Study Start (Actual): April 1, 2022
• Primary Completion (Anticipated): July 1, 2022
• Study Completion (Anticipated): July 7, 2022

Study Registration Dates

• First Submitted: May 20, 2022
• First Submitted That Met QC Criteria: May 20, 2022
• First Posted (Actual): May 25, 2022

Study Record Updates

• Last Update Posted (Actual): May 26, 2022
• Last Update Submitted That Met QC Criteria: May 24, 2022
• Last Verified: May 1, 2022

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Infections; Stomatognathic Diseases; Periodontal Diseases; Gingival Diseases; Gingivitis; Mouth Diseases
• Other Study ID Numbers: Moringa toothpaste

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No