The Effect of the 3/7 vs 3X9 Method in Resistance Training on Metabolic Stress in Cardiac Rehabilitation

Acute Effects of the 3/7 Method and 3X9 Method in Resistance Training on Testosterone, Glucocorticoid Cortisol, Growth Hormone and Lactate in Heart Failure and Coronary Artery Disease During Cardiac Rehabilitation

The study proposes to measure the effect of resitance training (RT) (3/7 method) on biological markers of muscle hypertrophy in a cardiac population.

3/7 method consisting of five sets of an increasing number of repetitions (3 to 7) during successive sets and brief inter-set intervals (15 s). This method is compare to 3X9 method, 3 series of 9 repetitions with inter-set (1min).The training exercise consisted of contraction on machine (leg press, triceps press, leg curl, traction, leg extension) with load of ~ 70% of one repetition maximal (1RM).

Before these trainings all subject perform HIIT on bicycles (2 min high intensity (80% Wmax) and 2 min low intensity (50% Wmax) during 30 minutes.

The investigators collect blood sample before exercice, after HIIT and after RT.

It is randomized cross-over study.

Study Overview

• Status: Completed
• Conditions: Coronary Artery Disease; Heart Failure; Resistance Training
• Intervention / Treatment: Other: Cardiac rehabilitation with 3/7 method; Other: Cardiac rehabilitation with 3X9 method

Detailed Description

The subjects come on two different days minimum 2 days and maximum 10 days between the two tests. They were instructed to avoid exercise the day before they participated in the study.

The investigators collect blood 2 minutes after endurance training (HIIT) and 2 min after RT training.

• Study Type: Interventional
• Enrollment (Actual): 25
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Belgium
  • Brussels, Belgium, 1070
    • Erasme Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Clinical Coronary artery diseases
• Heart failure with reduced ejection fraction

Exclusion Criteria:

• angina
• acutely decompensated heart failure
• electrocardiographic evidence of ischemia
• significant valvular disease
• orthopedic/neurologic disorders that limited exercise

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: CAD group; Coronary artery diseases	Other: Cardiac rehabilitation with 3/7 method; HIIT ( 2 min 80% wmax: 2 min 50% wmax) during 30 minutes 3/7 method 3 rep (15 sec of rest), 4 rep (15 sec), 5 rep (15 sec), 6 rep (15 sec), 7 rep. (total volume : 25 repetitions) at 70 of 1 repetition Leg press, Dips Press, Leg curl, Traction and Leg extension. 1 minute between each machine is planned.; Other Names: 3/7 method; Other: Cardiac rehabilitation with 3X9 method; HIIT ( 2 min 80% wmax: 2 min 50% wmax) during 30 minutes 3X9 method 9 rep 1 minute of rest, 9 rep (1 min) and 9 rep (total volume : 27 repetitions) at 70 of 1 repetition Leg press, Dips Press, Leg curl, Traction and Leg extension. 1 minute between each machine is planned; Other Names: 3X9 method
Experimental: HFrEF group; Heart Failure with reduced Ejection Fraction	Other: Cardiac rehabilitation with 3/7 method; HIIT ( 2 min 80% wmax: 2 min 50% wmax) during 30 minutes 3/7 method 3 rep (15 sec of rest), 4 rep (15 sec), 5 rep (15 sec), 6 rep (15 sec), 7 rep. (total volume : 25 repetitions) at 70 of 1 repetition Leg press, Dips Press, Leg curl, Traction and Leg extension. 1 minute between each machine is planned.; Other Names: 3/7 method; Other: Cardiac rehabilitation with 3X9 method; HIIT ( 2 min 80% wmax: 2 min 50% wmax) during 30 minutes 3X9 method 9 rep 1 minute of rest, 9 rep (1 min) and 9 rep (total volume : 27 repetitions) at 70 of 1 repetition Leg press, Dips Press, Leg curl, Traction and Leg extension. 1 minute between each machine is planned; Other Names: 3X9 method

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in Lactate	mmol/l	within 2 minutes after TR training session on day 1
change in Testosterone	nmol/l	within 2 minutes after TR training session on day 1
change Glucocorticoid Cortisol	nmol/l	within 2 minutes after TR training session on day 1
change in Growth Hormone	ng/ml	within 2 minutes after TR training session on day 1
change in ph	venoust	within 2 minutes after TR training session on day 1
change PCO2 venoust	mm Hg	within 2 minutes after TR training session on day 1

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Borg scale	Borg Rating of Perceived Exertion - Borg modified (0 = no exertion at all -10 maximal exertion)	within 4 minutes after TR training session on day 1
Pleasure of the session scale	0 = worse 10 = better	within 4 minutes after TR training session on day 1

Collaborators and Investigators

• Sponsor: Université Libre de Bruxelles
• Investigators: Study Director: Philippe van de borne, Professor, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium

Publications and helpful links

General Publications

• Mang ZA, Realzola RA, Ducharme J, Bellissimo GF, Beam JR, Mermier C, de Castro Magalhaes F, Kravitz L, Amorim FT. The effect of repetition tempo on cardiovascular and metabolic stress when time under tension is matched during lower body exercise. Eur J Appl Physiol. 2022 Jun;122(6):1485-1495. doi: 10.1007/s00421-022-04941-3. Epub 2022 Apr 8.

Study record dates

Study Major Dates

• Study Start (Actual): February 22, 2022
• Primary Completion (Actual): June 10, 2022
• Study Completion (Actual): October 25, 2022

Study Registration Dates

• First Submitted: April 7, 2022
• First Submitted That Met QC Criteria: May 20, 2022
• First Posted (Actual): May 26, 2022

Study Record Updates

• Last Update Posted (Actual): February 14, 2024
• Last Update Submitted That Met QC Criteria: February 13, 2024
• Last Verified: February 1, 2024

More Information

Terms related to this study

• Keywords: exercise therapy; Cardiac rehabilition; metabolic stress
• Additional Relevant MeSH Terms: Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Heart Failure; Coronary Artery Disease; Myocardial Ischemia; Coronary Disease
• Other Study ID Numbers: 2020276

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: on request

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No