3/7 Resistance Training Method in Cardiac Rehabilitation

3/7 Resistance Training Method in Cardiac Rehabilitation of Coronary Artery Disease and Heart Failure With Reduced Ejection Fraction

Aim of the clinical monocentric study is to assess the resistance training exercise intervention in patients with Heart Failure with reduced Ejection Fraction (HFrEF) and coronary artery disease that will best improve peak oxygen uptake (Peak Vo2) and leg strength (assessed Isokinetic). The investigators hypothesize that resistance training exercise with induced a high stress metabolic is more important exercise with induced than a lower stress metabolic.

Study Overview

• Status: Completed
• Conditions: Coronary Artery Disease; Heart Failure
• Intervention / Treatment: Other: 3/7 Resistance Training Method; Other: 3X9 Resistance Training Method

• Study Type: Interventional
• Enrollment (Actual): 112
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Belgium
  • Brussels, Belgium, 1070
    • Erasme Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• Clinical Coronary artery diseases
• Heart failure with reduced ejection fraction

Exclusion Criteria:

• angina
• acutely decompensated heart failure
• electrocardiographic evidence of ischemia
• significant valvular disease
• orthopedic/neurologic disorders that limited exercise

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: 3/7 RT method; perform interval- type endurance exercise at high intensity and resistance training with the 3/7 method	Other: 3/7 Resistance Training Method; 3/7 Resistance Training Method
Active Comparator: 3X9 RT method; perform interval- type endurance exercise at high intensity and resistance training with the 3X9 method	Other: 3X9 Resistance Training Method; 3X9 Resistance Training Method

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in Peak VO2 after 3 months	Change in Peak oxygen consumption (VO2) after three 3 months intervention	Baseline and 3 months
Change in strength knee extensor after 3 months	Change in strength knee extensor (60°/sec) after three months intervention	Baseline and 3 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in VE/VCO2 slope after 3 months	Change in ventilatory efficiency (VE/VCO2) slope at baseline and 3 months intervention	Baseline and 3 months
Change in submaximal exercise capacity after 3 months	Submaximal exercise capacity will be measured using watts at the first ventilatory threshold (VT1)	Baseline and 3 months
Change in workload maximal after 3 months	Change in workload max at baseline and 3 months intervention	Baseline and 3 months
Change in Body fat after 3 months	Change in Body fat at baseline and 3 months intervention	Baseline and 3 months
Change in lean mass after 3 months	Change in lean mass at baseline and 3 months intervention	Baseline and 3 months
Change in leg lean mass after 3 months	Change in leg lean mass at baseline and 3 months intervention	Baseline and 3 months
Change in bone mass after 3 months	Change in bone mass at baseline and 3 months intervention	Baseline and 3 months
Change in Visceral adipose tissue after 3 months	Change in Visceral adipose tissue measure by Dual-energy X- ray absorptiometry (DEXA) at baseline and 3 months intervention	Baseline and 3 months
Change in hand grip force after 3 months	Change in hand grip force on non dominant hand at baseline and 3 months intervention	Baseline and 3 months
Change in ventilation metaboreflex function after 3 months	Change in ventilation during metaboreflex test at baseline and 3 months intervention (Briefly, the subject is asked to exercise with the non-dominant arm by performing two 5 min handgrip manoeu- vres reaching approximately 50% of pre-determined maximal con- traction, in random order, separated by a 30 min interval: one bout with circulatory occlusion during the last 10 s of exercise and the all 3 min recovery phase ('clamp session'). During the clamp session, forearm cuff inflation to 30 mmHg above systolic blood pressure from the last 10 s of exercise till the end of the 3 min recovery phase; after cuff inflation, the subject is instructed to relax. Ergore- ceptor sensitivity is quantified as the percentage of the ventilatory and haemodynamic response to exercise maintained by circulatory occlusion during the third minute compared with the third minute of basal recovery.)	Baseline and 3 months
Change in diastolic blood pressure metaboreflex function after 3 months	Change in diastolic blood pressure during metaboreflex test at baseline and 3 months intervention	Baseline and 3 months
Change in heart rate at rest after 3 months	Change in heart rate at baseline and 3 months intervention	Baseline and 3 months
Change in resting heart rate variability at rest after 3 months	Change in resting heart rate variability at baseline and 3 months intervention	Baseline and 3 months
Change 30 s sit-to-stand after 3 months	Change 30 s sit-to-stand at baseline and 3 months intervention	Baseline and 3 months
Change in isometric strength knee extensor after 3 months	Change in strength knee extensor (isometric) at baseline and 3 months intervention	Baseline and 3 months
Change in 120°/sec strength knee extensor after 3 months	Change in strength knee extensor (120°/sec) at baseline and 3 months intervention	Baseline and 3 months
Change in 180°/sec strength knee extensor after 3 months	Change in strength knee extensor (180°/sec) at baseline and 3 months intervention	Baseline and 3 months
Change strength knee extensor in leg extension after 3 months	Change in one repetition maximal in leg extensor machine at baseline and 3 months intervention	Baseline and 3 months
Change in sub maximal strength knee extensor in leg extension after 3 months	Change in 10 repetitions maximal in leg extensor machine at baseline and 3 months intervention	Baseline and 3 months
Change in heart rate recovery after 3 months	Change in heart rate recovery at baseline and 3 months intervention	Baseline and 3 months

Collaborators and Investigators

• Sponsor: Université Libre de Bruxelles
• Investigators: Principal Investigator: Alexis Gillet, Université Libre de Bruxelles

Publications and helpful links

General Publications

• Stragier S, Baudry S, Carpentier A, Duchateau J. Efficacy of a new strength training design: the 3/7 method. Eur J Appl Physiol. 2019 May;119(5):1093-1104. doi: 10.1007/s00421-019-04099-5. Epub 2019 Feb 12.
• Duchateau J, Stragier S, Baudry S, Carpentier A. Strength Training: In Search of Optimal Strategies to Maximize Neuromuscular Performance. Exerc Sport Sci Rev. 2021 Jan;49(1):2-14. doi: 10.1249/JES.0000000000000234.

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2019
• Primary Completion (Actual): March 1, 2023
• Study Completion (Actual): August 30, 2023

Study Registration Dates

• First Submitted: January 11, 2023
• First Submitted That Met QC Criteria: January 20, 2023
• First Posted (Actual): January 25, 2023

Study Record Updates

• Last Update Posted (Estimated): February 15, 2024
• Last Update Submitted That Met QC Criteria: February 13, 2024
• Last Verified: February 1, 2024

More Information

Terms related to this study

• Keywords: strength training; resistance training; cardiac rehabilitation; exercise for older adults
• Additional Relevant MeSH Terms: Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Heart Failure; Coronary Artery Disease; Myocardial Ischemia; Coronary Disease
• Other Study ID Numbers: P2020/489

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No