The Effect of Exercise on Cognitive Status in Older Adults

Is Aerobic and Dual-task Training Combination the Most Effective Exercise Combination to Improve the Cognitive Status and Physical Function in Older Adults With Mild Cognitive Decline

The purpose of the study is to demonstrate the effectiveness of the different combinations of exercises on the cognitive status of older adults with cognitive decline.

Study Overview

• Status: Completed
• Conditions: Older People
• Intervention / Treatment: Other: Aerobic exercise training combined with lower limb strengthening; Other: Dual-task training combined with lower limb strengthening group (DG); Other: Aerobic exercise training combined with dual-task training and lower limb strengthening; Other: Only lower limb strengthening group (CG)

Detailed Description

This study is planned to examine the effects of combined exercise on cognitive status, lower extremity muscle strength, mobility, physical performance, mood and quality of life in older adults with Mild Cognitive Impairment. Aerobic exercise training and lower limb (extremity) strengthening exercises were applied to the first group, dual-task training and lower limb strengthening exercises were applied to the second group, and aerobic exercise training, dual-task training and lower limb strengthening exercises were applied to the third group.

• Study Type: Interventional
• Enrollment (Actual): 48
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Turkey
  • Ankara, Turkey, 06500
    • Gazi University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 65 years and older (Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Not had a fall in the last six months.
• Older adults with an mini mental state examination score between18-23.
• Age ≥ 65years.

Exclusion Criteria:

• having central nervous system pathology that will affect balance
• diagnosed with vestibular pathology,
• having deformities in the waist, hip, and knee joints,
• having lower extremity amputation,
• with lower extremity operation history,
• malignancy affecting the lower extremity,
• having moderate and severe congenital heart disease, coronary heart disease and cerebrovascular disease,
• participants who cannot cooperate,
• participants who use an assistive walking device,
• participants having vision problems.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Aerobic exercise training combined with lower limb strengthening group (AG); Aerobic exercise training combined with lower limb strengthening.	Other: Aerobic exercise training combined with lower limb strengthening; The participants performed aerobic exercise training and lower limb strengthening during this intervention.
Experimental: Dual-task training combined with lower limb strengthening group (DG); Dual-task training combined with lower limb strengthening.	Other: Dual-task training combined with lower limb strengthening group (DG); The participants performed dual-task training combined with lower limb strengthening during this intervention.
Experimental: Aerobic exercise training combined with dual-task training and lower limb strengthening group (ADG); Aerobic exercise training combined with dual-task training and lower limb strengthening.	Other: Aerobic exercise training combined with dual-task training and lower limb strengthening; The participants performed aerobic exercise training combined with dual-task training and lower limb strengthening during this intervention.
Active Comparator: Only lower limb strengthening group (CG); Only lower limb strengthening.	Other: Only lower limb strengthening group (CG); The participants performed only lower limb strengthening group during this intervention.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mini-Mental State Examination	Cognitive status examination is applied with a simple test called "Mini-Mental State Examination".	12 weeks
Commander Power Track 2 Manual Tester	Muscle strength strength is carried out with "Commander Power Track 2 Manual Tester".	12 weeks
Timed Up and Go Test	Functional mobility is evaluated by Timed Up and Go Test.	12 weeks
Single Leg Stance Test	Static balance is evaluated by Single Leg Stance Test	12 weeks
Activities-specific Balance Confidence Scale	Balance Confidence is evaluated by Activities-specific Balance Confidence Scale.	12 weeks
Six-Minute Walk Test	Exercise capacity is evaluated by Six-Minute Walk Test.	12 weeks
Short Physical Performance Battery	Physical performance is evaluated by Short Physical Performance Battery.	12 weeks
Hamilton Depression Rating Scale	Emotional status is evaluated by Hamilton Depression Rating Scale	12 weeks
World Health Organization Quality of Life-Old module	Quality of life is evaluated by World Health Organization Quality of Life-Old module	12 weeks

Collaborators and Investigators

• Sponsor: Muğla Sıtkı Koçman University
• Investigators: Principal Investigator: İsmail Uysal, PhD, Muğla Sıtkı Koçman University

Study record dates

Study Major Dates

• Study Start (Actual): January 30, 2019
• Primary Completion (Actual): December 1, 2019
• Study Completion (Actual): February 1, 2020

Study Registration Dates

• First Submitted: September 4, 2022
• First Submitted That Met QC Criteria: September 4, 2022
• First Posted (Actual): September 8, 2022

Study Record Updates

• Last Update Posted (Actual): September 8, 2022
• Last Update Submitted That Met QC Criteria: September 4, 2022
• Last Verified: September 1, 2022

More Information

Terms related to this study

• Other Study ID Numbers: Gazi University (Other Identifier: Research Projects Coordination Unit)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No