Ureteric Jet Doppler Waveforms in Patients With Spinal Cord Injury

The Characteristics of Ureteric Jet Doppler Waveforms and Factors Affecting Them in Patients With Spinal Cord Injury

Urinary dysfunction is very common in individuals with spinal cord injury. The urine flowing from the collecting ducts to the renal calyx stretches the calyces. ANS controlled peristaltic contractions originate in the proximal renal pelvis and travel down the ureters, pushing urine from the renal pelvis towards the bladder. The urine bolus delivered from the kidneys through the peristaltic contraction of the ureter creates an image called ureteric jet. Using the Doppler analysis of ureteral jets, previous studies have examined the changes in the ureteric jet pattern in pathological conditions such as the diagnosis of normal ureteral physiology.

Study Overview

• Status: Completed
• Conditions: Spinal Cord Injuries
• Intervention / Treatment: Diagnostic test: Doppler ultrasound, Urodynamic assessment.; Diagnostic test: Urodynamic assessment.

Detailed Description

This cross-sectional study was conducted at a tertiary rehabilitation center. Eighteen spinal cord injury patients who met the inclusion criteria and 24 healthy volunteers were included in the study. The appearance of üreteric jet form and bladder wall thicknesses were obtained by urinary Doppler ultrasound both in patient and control groups. Detrusor pressure and bladder volume were measured only in patient group during urodynamic assessment.

• Study Type: Observational
• Enrollment (Actual): 42

Contacts and Locations

Study Locations

• Turkey
  • Çankaya
    • Ankara, Çankaya, Turkey, 06100
      • Gaziler PMR, Training and Research Hospital, Department of PMR

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 65 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Spinal cord injury patients who were hospitalized in the spinal cord injury Rehabilitation Unit of our rehabilitation center and 32 no spinal cord injury who presented at outpatient clinics.

Description

The case group

Inclusion Criteria:

• With signs of upper motor neuron lesion,
• Suprasacral spinal cord injury,
• Normal urinary ultrasound findings
• Planned urodynamics

Exclusion Criteria:

• Neurological disease other than spinal cord injury
• Urinary tract infection
• Urinary obstruction
• History of urinary tract Stones
• Diabetes, hypertension
• History of urinary surgery,
• Sacral injury
• Second motor neuron lesions (such as cauda equina, or cauda conus)

The control group

Inclusion Criteria:

• Normal urinary ultrasonography

Exclusion Criteria:

• Neurological disease
• Urinary tract infection
• Urinary obstruction
• History of urinary tract Stones
• Diabetes, hypertension

Study Plan

How is the study designed?

Design Details

• Observational Models: Case-Control
• Time Perspectives: Cross-Sectional

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
spinal cord injury; patient with spinal cord injury	Diagnostic test: Doppler ultrasound, Urodynamic assessment.; The patients included in the study group were given 600 cc of water in the morning and the Doppler ultrasound was performed 30 minutes later; Diagnostic test: Urodynamic assessment.; A transurethral double lumen catheter was used to measure intravesical pressure in the urodynamic unit for the patients in the study group immediately after the use of the Doppler USG
no spinal cord injury; patient without spinal cord injury	Diagnostic test: Doppler ultrasound, Urodynamic assessment.; The patients included in the study group were given 600 cc of water in the morning and the Doppler ultrasound was performed 30 minutes later

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
doppler USG	The patients included in the study group were given 600 cc of water in the morning and the Doppler USG was performed 30 minutes later	15-30 minute
Urodynamic assessment.	A transurethral double lumen catheter was used to measure intravesical pressure in the urodynamic unit	30 minute

Collaborators and Investigators

• Sponsor: Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
• Investigators: Principal Investigator: İlkay Karabay, Gaziler Physical Medicine and Rehabilitation Education and Research Hospital

Study record dates

Study Major Dates

• Study Start (Actual): June 17, 2021
• Primary Completion (Actual): March 20, 2022
• Study Completion (Actual): September 30, 2022

Study Registration Dates

• First Submitted: October 1, 2022
• First Submitted That Met QC Criteria: October 3, 2022
• First Posted (Actual): October 6, 2022

Study Record Updates

• Last Update Posted (Actual): October 7, 2022
• Last Update Submitted That Met QC Criteria: October 5, 2022
• Last Verified: October 1, 2022

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Central Nervous System Diseases; Nervous System Diseases; Trauma, Nervous System; Spinal Cord Diseases; Wounds and Injuries; Spinal Cord Injuries
• Other Study ID Numbers: ik

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No