Evaluation and Characterisation of Microplastics and Nanoplastics in Joint Synovial Liquid

January 3, 2023 updated by: Ciubean Alina Deniza, Universitatea de Medicina si Farmacie Iuliu Hatieganu

The research study aims to evaluate the synovial fluid to highlight the presence of possible micropolymers (micro/nanoplastics) in order to better understand the pathophysiology of joint degenerative processes. For patients with liquid under tension at the joint level, the symptomatology often requires evacuation by puncture under ultrasound guidance. The intervention will be performed only for patients for whom this therapeutic indication exists anyway by their physician.

The investigators want to use this liquid for Microscopic and Spectrophotometric evaluation.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Diagnostic test: Synovial fluid analysis

Study Type

Observational

Enrollment (Anticipated)

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 90 years (Adult, Older Adult)

Accepts Healthy Volunteers

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Inpatients on a Rehab Department with arthritis of the knee that require evacuation of the knee joint

Description

Inclusion Criteria:

arthritis of the knee with liquid aspiration recommendation
age >18 years

Exclusion Criteria:

--refusal of the patient to participate

-age<18 years

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Observational Models: Cohort
Time Perspectives: Prospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
microplastics Time Frame: immediately after liquid extraction	evaluation with spectrophotometry and optic microscopy	immediately after liquid extraction
nanoplastics Time Frame: immediately after liquid extraction	evaluation with spectrophotometry and optic microscopy	immediately after liquid extraction

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Universitatea de Medicina si Farmacie Iuliu Hatieganu

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Anticipated)

January 15, 2023

Primary Completion (Anticipated)

December 15, 2023

Study Completion (Anticipated)

December 15, 2024

Study Registration Dates

First Submitted

December 15, 2022

First Submitted That Met QC Criteria

January 3, 2023

First Posted (Estimate)

January 10, 2023

Study Record Updates

Last Update Posted (Estimate)