- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02878941
Synovial Fluid Analysis of Intraarticular Elbow Fracture
July 2, 2020 updated by: Duke University
The objective of this study is to obtain and compare bilateral elbow joint synovial fluid from patients with unilateral intraarticular elbow fracture and a contralateral healthy appearing elbow joint.
The synovial fluid samples will undergo several forms of analysis for metabolites and proteins.
Matched-pair statistical analysis will be performed to determine the metabolites and proteins that may play the greatest role in development of joint contracture.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
12
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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North Carolina
-
Durham, North Carolina, United States, 27710
- Duke University Medical Center
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- 18 years and older
- Intraarticular elbow fracture (humerus, radial head and/or ulna fracture)
Exclusion Criteria:
- Age <18 years
- Open elbow fracture
- Bilateral elbow fractures
- Patients with history of osteomyelitis of elbow
- Inflammatory arthropathy (ie. Rheumatoid arthritis)
- Prior surgery on fractured elbow
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: BASIC_SCIENCE
- Allocation: NA
- Interventional Model: SINGLE_GROUP
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
OTHER: Elbow Fracture
Patients with an intraarticular elbow fracture and/or dislocation.
Synovial fluid from the injured elbow will be obtained during the subject's emergency department encounter by one of the Chief Residents or Attending surgeon as part of standard of care procedures for pain control-related injection and aspiration.
Patients with an intraarticular elbow fracture and/or dislocation receive an intraarticular elbow injection with anesthetic (i.e.
lidocaine or marcaine) to provide analgesia for elbow range of motion testing and orthopaedic reduction maneveuers as the current standard of care.
The patients would be asked to consent for 2 elbow joint aspirations: 1.Aspiration of the injured elbow at time of surgical fracture fixation; 2.Aspiration of the uninjured elbow at time of surgical fracture fixation.
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Synovial fluid aspiration (act of using an 18 gauge needle to obtain synovial fluid from the elbow) in the emergency room for patients with the eligible elbow fracture (as defined in inclusion/exclusion criteria) is performed in conjunction with the anesthetic injection as part of standard of care.
The elbow will be prepped as per usual for the anesthetic injection.
An 18 gauge needle will be inserted through a lateral approach.
The subject's elbow will be aspirated.
The syringe with the aspirate would be removed from the needle while the needle would remain in the subject's elbow joint.
The syringe with anesthetic would then be connected to the needle, and the anesthetic would be injected into the elbow joint.
Therefore, no risks from a separate aspiration would be conferred to the patient.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
metabolite composition of synovial fluid
Time Frame: time of fracture until surgical fixation (up to 5 weeks after injury)
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time of fracture until surgical fixation (up to 5 weeks after injury)
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
May 1, 2017
Primary Completion (ACTUAL)
March 6, 2019
Study Completion (ACTUAL)
May 17, 2020
Study Registration Dates
First Submitted
July 13, 2016
First Submitted That Met QC Criteria
August 22, 2016
First Posted (ESTIMATE)
August 25, 2016
Study Record Updates
Last Update Posted (ACTUAL)
July 7, 2020
Last Update Submitted That Met QC Criteria
July 2, 2020
Last Verified
January 1, 2020
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- Pro00072559
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
UNDECIDED
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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