The Efficacy of Topical Serum X for Skin Brightening

The Efficacy of Topical Serum X Containing Arbutin and Glutathione for Skin Brightening

This study is conducted to evaluate the effectiveness of topical serum X containing arbutin and glutathione for skin brightening. The study duration is 12 weeks and the skin assessment will be carried out at baseline, week 4, 8 and week 12.The main questions this study aims to answer are:

1. The skin brightening effect of the product on facial skin.
2. To observe any adverse effect occurrence with the usage of the product.

Study Overview

• Status: Completed
• Conditions: Healthy
• Intervention / Treatment: Other: Other: Serum X

• Study Type: Interventional
• Enrollment (Actual): 34
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Malaysia
  • Selangor
    • Petaling Jaya, Selangor, Malaysia, 47810
      • Ungku Shahrin Medical Aesthetic Research & Innovation (USMARI) Centre

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 30 years (Adult)
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Malaysia citizen
• Male and female (age 18-30 years old)

Exclusion Criteria:

• Participant with severe acne skin condition
• Participant who is taking isotretinoin, immunocompromised patients and received laser and light treatment within the last three months
• Participant who undergo whitening or cosmetic treatments such as botox and dermal fillers within the previous six month
• Participant with a history of facial surgery such as facelift or nose reshaping
• Participant with history of allergies to any ingredient in the study product
• Participant who is pregnant or plan to get pregnant

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Serum X; Participants will used serum X twice daily for 12 weeks	Other: Other: Serum X; Serum X contain arbutin and glutathione

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes in skin tone from baseline and at week 4, week 8, and week 12 after usage of serum X.	Skin tone will be assessed using JANUS III skin analyzer	Baseline and at week 4, week 8, and week 12
Adverse effect after using serum X	Based on adverse effect occurrence on participants that occur during study period (12 weeks	Week 12

Collaborators and Investigators

• Sponsor: Ungku Shahrin Medical Aesthetic Research & Innovation (USMARI) Centre

Study record dates

Study Major Dates

• Study Start (Actual): September 1, 2022
• Primary Completion (Actual): May 31, 2023
• Study Completion (Actual): September 1, 2023

Study Registration Dates

• First Submitted: January 11, 2023
• First Submitted That Met QC Criteria: January 11, 2023
• First Posted (Actual): January 23, 2023

Study Record Updates

• Last Update Posted (Actual): November 29, 2023
• Last Update Submitted That Met QC Criteria: November 27, 2023
• Last Verified: November 1, 2023

More Information

Terms related to this study

• Keywords: Cosmetic; Aesthetic
• Other Study ID Numbers: UMRAMREC001-22

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No