Predictors of Failure of Non-invasive Ventilation and High Flow Nasal Cannula

Predictors of Failure of Non-invasive Ventilation and High Flow Nasal Cannula in Acute Respiratory Failure Patients : the Standardized PaO2 / FiO2 Ratio (P /F-st), ROX Index and HACOR

Comparison between some predictors of failure of non-invasive ventilation and high flow nasal cannula.

Study Overview

• Status: Not yet recruiting
• Conditions: Acute Respiratory Failure Patients on NIV and HFNC

Detailed Description

Delayed intubation after NIV / HFNC failure is associated with high mortality rate in acute respiratory failure patients.

There are Many factors to predict early failure but World still searching for new factors and comparing between each ;in order to eatablish best one that achieve the least mortality rate.

Little studies about effiecacy of HACOR Score as a predictor of failure in HFNC patients.

Little studies about effiecacy of ROX Index as a predictor of failure in NIV ventilating patients.

• Study Type: Observational
• Enrollment (Anticipated): 120

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: N/A

• Sampling Method: Non-Probability Sample

Study Population

Patient in chest and Tuberculosis Departement, Assiut University

Description

Inclusion Criteria:

Acute respiratory failure patients who need ventilatory Support either NIV or HFNC due to :

1. RR > 25 cycle / min
2. using accessory muscles and paradoxical breath.
3. PaO2 / FiO2 ratio < 300

Exclusion Criteria:

1. Absolute indication for intubation like coma, haemodynamically unstable… etc
2. Contr-indication of NIV like untreated Pneumothorax.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Determine Golden time for intubation	Determine best time for intubation according to some predictors of failure of NIV and HFNC	1 year

Collaborators and Investigators

• Sponsor: Assiut University

Study record dates

Study Major Dates

• Study Start (Anticipated): July 1, 2023
• Primary Completion (Anticipated): April 1, 2024
• Study Completion (Anticipated): July 1, 2024

Study Registration Dates

• First Submitted: March 22, 2023
• First Submitted That Met QC Criteria: May 16, 2023
• First Posted (Actual): May 18, 2023

Study Record Updates

• Last Update Posted (Actual): May 18, 2023
• Last Update Submitted That Met QC Criteria: May 16, 2023
• Last Verified: May 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Respiratory Tract Diseases; Respiration Disorders; Lung Diseases; Respiratory Insufficiency; Respiratory Distress Syndrome
• Other Study ID Numbers: NIV and HFNC

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No