Variation of Echocardiographic Parameters After Red Blood Cell Transfusion in Emergency Department Anemic Patients (Trans-US)

December 22, 2025 updated by: Centre Hospitalier Universitaire de Nīmes

The goal of this interventional study is to asses echocardiographic variations in emergency department's elderly patients receiving red blood cell transfusion. The main questions it aims to answer are :

  • is there a modification of echocardiographic parameters after red blood cell transfusion ?
  • which parameter is the most impacted by red blood cell transfusion ? Participants will have a transthoracic echocardiography before, just after and 15 minutes after red blood cell transfusion.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

116

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
    • Gard
      • Nîmes, Gard, France, 30900
        • Recruiting
        • CHU de Nîmes
        • Contact:
        • Sub-Investigator:
          • Laura Grau-Mercier, MD
        • Principal Investigator:
          • Fabien COISY, MD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • patient needing red blood cell transfusion
  • consent
  • social protection

Exclusion Criteria:

  • fluid filing over 500 mL of crystalloids
  • transfusion in the last hour

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Diagnostic
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: transfused patients
patients receiving red blood cell transfusion
Diagnostic test: transthoracic echocardiography
E wave, A wave, e' and vdi measurement

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
E/A ratio modification
Time Frame: Base line, just after and 15 minutes after red blood cell transfusion
E/A ratio permits to estimate left ventricle pressure
Base line, just after and 15 minutes after red blood cell transfusion

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
E/e' ratio modification
Time Frame: Base line, just after and 15 minutes after red blood cell transfusion
E/e' assesses left ventricle diastolic function
Base line, just after and 15 minutes after red blood cell transfusion
E wave deceleration time
Time Frame: Base line, just after and 15 minutes after red blood cell transfusion
E wave deceleration time is a reflect of left atrium pressures
Base line, just after and 15 minutes after red blood cell transfusion
Lung score modification
Time Frame: Base line, just after and 15 minutes after red blood cell transfusion
Lung score permits to asses if extravascular water is present in lungs
Base line, just after and 15 minutes after red blood cell transfusion
Velocity-time Integral (VTI) modification
Time Frame: Base line, just after and 15 minutes after red blood cell transfusion
Aortic velocity-time integral is the reflect of cardiac output
Base line, just after and 15 minutes after red blood cell transfusion
New York Heart Association scale (NYHA) modification
Time Frame: baseline and 24 hour after red blood cells transfusion
NYHA is a validated scale to asses patient dyspnea
baseline and 24 hour after red blood cells transfusion

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Centre Hospitalier Universitaire de Nīmes

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 9, 2023

Primary Completion (Estimated)

May 30, 2027

Study Completion (Estimated)

May 30, 2027

Study Registration Dates

First Submitted

September 25, 2023

First Submitted That Met QC Criteria

September 25, 2023

First Posted (Actual)

September 29, 2023

Study Record Updates

Last Update Posted (Actual)

December 30, 2025

Last Update Submitted That Met QC Criteria

December 22, 2025

Last Verified

December 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2023-A01236-39

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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