Resistance Exercise Training in Children.

The Effects of Resistance Exercise on Muscle Activation and Lipids in Children

The purpose of this study is examine the effects of 8 weeks (3 days/week) of resistance exercise training in children 8 to 10 years of age on muscle strength, activation, and lipids of the vastus lateralis.

Study Overview

• Status: Completed
• Conditions: Resistance Training
• Intervention / Treatment: Other: Resistance exercise training

• Study Type: Interventional
• Enrollment (Actual): 32
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Kansas
    • Kansas City, Kansas, United States, 66103
      • Hoglund Biomedical Imaging Center
    • Overland Park, Kansas, United States, 66213
      • Exercise and Human Performance Laboratory
    • Overland Park, Kansas, United States, 66213
      • Metabolic and Body Composition Laboratory
  • Missouri
    • Kansas City, Missouri, United States, 64108
      • Energy Balance Laboratory

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Healthy volunteer males and females ages 8 - 10 years.

Exclusion Criteria:

• No history or ongoing neuromuscular diseases, musculoskeletal injuries, or a disease that effects metabolism.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Resistance exercise training; Participants undergo 8 weeks (3 days/week) of resistance exercise training.	Other: Resistance exercise training; Traditional linear periodization resistance training.
No Intervention: Control; Participants do not perform 8 weeks of resistance exercise training.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in the muscular strength of leg extensors, as measured with isometric strength.	The score will reflect the strength of the leg extensors. The higher score, reflects greater muscular strength.	baseline, following the intervention (9 weeks)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change from baseline in motor unit firing rates during a 60% of maximal voluntary contraction (MVC).	Scores are measured with the y-intercept from the firing rates versus recruitment threshold relationships from the 60%. The higher y-intercept score reflects greater muscle activation.	baseline, following the intervention (9 weeks)
Change from baseline in motor unit firing rates during a 60% of maximal voluntary contraction (MVC).	Scores are measured with the slope from the firing rates versus recruitment threshold relationships from the 60%. The higher slope score reflects greater muscle activation.	baseline, following the intervention (9 weeks)
Change from baseline in thigh muscle cross-sectional area.	Scores are measured cross-sectional area from ultrasound images.	baseline, following the intervention (9 weeks)

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change from baseline in the fatty acid saturation levels of the extramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy	The score will reflect a saturation level of fatty acids in the extramyocellular lipid. The higher score, reflects greater fatty acid saturation.	baseline, following the intervention (9 weeks)
Change from baseline in the fatty acid saturation levels of the intramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy	The score will reflect a saturation level of fatty acids in the intramyocellular lipid. The higher score, reflects greater fatty acid saturation.	baseline, following the intervention (9 weeks)
Change from baseline in motor unit firing rates during a 35% of maximal voluntary contraction (MVC).	Scores are measured with the y-intercepts from the firing rates versus recruitment threshold relationships from the 35%. The higher y-intercept score reflects greater muscle activation.	baseline, following the intervention (9 weeks)
Change from baseline in motor unit firing rates during a 35% of maximal voluntary contraction (MVC).	Scores are measured with the slopes from the firing rates versus recruitment threshold relationships from the 35%. The higher slope score reflects greater muscle activation.	baseline, following the intervention (9 weeks)
Change from baseline in intramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy	The score will reflect a concentration. The higher score, reflects more fat in the fibers.	baseline, following the intervention (9 weeks)
Change from baseline in extramyocellular lipids of the vastus lateralis, as measure with magnetic resonance spectroscopy	The score will reflect a concentration. The higher score, reflects more fat in the fibers.	baseline, following the intervention (9 weeks)

Collaborators and Investigators

• Sponsor: University of Kansas Medical Center
• Collaborators: National Strength and Conditioning Association

Study record dates

Study Major Dates

• Study Start (Actual): August 2, 2021
• Primary Completion (Actual): September 6, 2023
• Study Completion (Actual): September 6, 2023

Study Registration Dates

• First Submitted: October 5, 2023
• First Submitted That Met QC Criteria: October 10, 2023
• First Posted (Actual): October 11, 2023

Study Record Updates

• Last Update Posted (Actual): October 13, 2023
• Last Update Submitted That Met QC Criteria: October 10, 2023
• Last Verified: October 1, 2023

More Information

Terms related to this study

• Keywords: exercise; strength; intramyocellular lipids; muscle cross-sectional area; extramyocellular lipids
• Other Study ID Numbers: STUDY00147248

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Sharing Supporting Information Type: ICF

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No