- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03889548
Influence of Resistance Training Experience and Mental Imagery on Corticospinal Excitability and Inhibition
Influence of Resistance Training Experience on the Efficacy of Mental Imagery in Modulating Corticospinal Excitability and Inhibition: A Pilot Study
Study Overview
Detailed Description
Kinesthetic mental imagery is a technique that has previously been utilized to modulate neural signaling to the limbs in the absence of any mechanical movement of the limb. Kinesthetic imagery tasks require an individual to imagine they are maximally contracting a target muscle group. Previous investigations have shown mental imagery tasks to increase maximal strength of the limb and even attenuate strength loss during periods of immobilization. Similarly, corticospinal excitability, which indicates the ease in which the cortex can stimulate muscular contraction, has also been shown to increase during mental imagery tasks. These adaptations have been attributed to the role of the cortex as a critical determinant of strength and the potent cortical stimulus posed by mental imagery.
Mental imagery and resistance training have both shown to provide a positive impact on muscle strength. However, the interplay between a mental imagery task and resistance training experience has yet to be fully investigated in terms of their impact on corticospinal excitability and inhibition. To our knowledge, no study has examined the effect of resistance training experience on corticospinal excitability and inhibition during a mental imagery task. Thus, the purpose of this study is to determine if resistance trained and untrained participants experience differences in corticospinal excitability and inhibition during kinesthetic mental imagery.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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Florida
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Orlando, Florida, United States, 32826
- Central Florida Research Park; Partnership 1 Building; UCF Neuromuscular Plasticity Laboratory
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Over the previous six months, participant has performed at least three resistance training sessions per week or
- Over the previous six months, participant has refrained from resistance training entirely.
Exclusion Criteria:
- Do not meet the resistance training experience requirements of either group
- Neuromuscular disease (e.g. Parkinson's, MS, ALS)
- Metabolic disease (e.g. diabetes, thyroid disorder, metabolic syndrome)
- Arthritis in the upper limbs (hands, arms, shoulders)
- Trouble using or controlling one's muscles
- History of cancer
- History of stroke
- History of heart attack
- Use of an assistive walking device or other mobility aids
- Physician mandated contraindication to exercise within the last 6 months
- Epilepsy or history of convulsions/seizures
- History of fainting or syncope
- History of head trauma that was diagnosed as concussion or was associated with loss of consciousness
- History of hearing problems or tinnitus
- Cochlear implants
- Implanted metal in the brain, skull, or elsewhere in the body
- Implanted neurotransmitter
- Cardiac pacemaker or intracardiac lines
- Medication infusion device
- Past problems with brain stimulation
- Past problems with MRI
- Use of muscle relaxants or benzodiazepines
- Allergy to rubbing alcohol
- Any other health related illnesses that would prohibit a participant from physical performance testing
- Lack of transportation to and from the laboratory
- Any permanent / non-removable jewelry or metal fixtures
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
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No Intervention: Control
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Experimental: Mental Imagery
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Immediately after determination of the resting motor threshold and pre-test measurements, the TMS administrator will leave the room so as to be blinded to the treatment condition of the participant.
At this time the participant will be given instructions regarding the mental imagery protocol from a separate investigator who will not be blinded to the condition.
During the mental imagery protocol, participants will be instructed to close their eyes and imagine they are maximally contracting the muscles in their forearm and imagine that they are making their wrist flex and that they are pushing maximally against a hand grip in their hand.
This will be a kinesthetic imagery task, in which they are urging their muscles to contract maximally.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Corticospinal Excitability
Time Frame: Greater than or equal to 24 hours to 7 days between visits.
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Peak-to-peak amplitude of the motor evoked potential of the first dorsal interosseous at 130% of resting motor threshold
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Greater than or equal to 24 hours to 7 days between visits.
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Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Matt S Stock, Ph.D., School of Kinesiology and Physical Therapy
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- 00000170
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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