Adaptive Response of Brain Towards Resistance Training in Healthy Individuals

May 9, 2024 updated by: Pakistan Society for Rehabilitation of Differently Abled Hospital
The novelty of this study is to identify the mechanism of nervous system by applying resistance training intervention in healthy individuals.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

Resistance training is a form of exercise that is popular particularly for its role in improving athletic performance by increasing muscular strength, power and speed, hypertrophy, local muscular endurance, motor performance, balance and coordination. The objective of the study is to find out the effects of resistance training on Central and Peripheral Nervous System in healthy individuals. A total of 100 participants will be included in the study including both male and female. The study will be divided into two main groups. Experimental group will perform 8-12 Reps with 1.5 sec concentric and 1.5 sec eccentric contraction of bench press with 90 sec of rest between sets with 2 sets per week for 2 months.

1RM of control group will be calculated through the same method and the training protocol for the Control group consisted of 5 attempts to lift as much weight as possible one time for that training visit with 90 seconds of rest between attempts. The load was progressively increased each attempt to try to reach or exceed their previous 1RM.

Study Type

Interventional

Enrollment (Estimated)

100

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Pakistan
    • Punjab
      • Lahore, Punjab, Pakistan, 54000
        • Recruiting
        • PSRD Hospital
        • Contact:
        • Principal Investigator:
          • Danish Latif, PhD*

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Body Mass Index should be 18.5-24.9 kg/m2.
  • Participants were untrained and had not engaged in resistance exercise within 6 months prior to beginning the study.

Exclusion Criteria:

  • Participants with any kind of Gastrointestinal Tract disturbance will be excluded from the study.
  • Participants with any kind of Musculoskeletal injury will be excluded from the study.
  • Participant with any kind of Neurological disturbance will be excluded from the study.
  • Participants who use tobacco products within the previous 6 months.
  • Participants who take any type of medication within the previous 6 months.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Hyper Training Group
2 training session per week for 2 months, 1 set of 10 unloaded repetitions in arms as a warm-up, 4 sets with a goal of 8-12 repetitions with 90 seconds of rest between sets and elbows had to be fully locked out to be counted as a repetition, 1.5 seconds for concentric and 1.5 seconds for eccentric portion.
Other: Hyper Training
Experimental group will perform 2 training session per week for 2 months, 1 set of 10 unloaded repetitions in arms as a warm-up, 4 sets with a goal of 8-12 Reps with 90 seconds rest between sets. 1.5 second concentric and 1.5 second eccentric contraction of bench press, The elbows had to be fully locked out to be counted as a repetition.
Active Comparator: 1 Repetition Maximum Group
2 training session per week for 2 months, 1 set of 10 unloaded repetitions in arms as a warm-up, training protocol consisted of 5 attempts to lift as much weight as possible one time for that training visit with 90 seconds of rest between attempts. The load was progressively increased each attempt to try to reach or exceed their previous 1RM.
Other: 1 Repetition maximum training group
2 training session per week for 8 weeks, 1 set of 10 unloaded repetitions in arms as a warm-up, 1 Repetition maximum training group consisted of 5 attempts to lift as much weight as possible one time for that training visit with 90 seconds of rest between attempts, the load was progressively increased each attempt to try to reach or exceed their previous 1 repetition maximum.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
NCS (Motor Nerve Conduction Study)
Time Frame: • 0 week • 8th week
To determine how fast or slow the nerves are conducting an electrical current using F wave
• 0 week • 8th week
EEG (Electroencephalography)
Time Frame: • 0 week • 8th week
To measure the electrical activity of the brain using alpha and beta waves
• 0 week • 8th week
Dynamometer
Time Frame: • 0 week • 4th week • 8th week
To measure the strength after resistance training
• 0 week • 4th week • 8th week
Estimation of Albumin & Globulin ratio
Time Frame: • 0 week • 8th week
To measure the total amount of protein in blood and effects of resistance training
• 0 week • 8th week

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Pakistan Society for Rehabilitation of Differently Abled Hospital

Collaborators

University of Karachi

Investigators

  • Principal Investigator: Danish Latif, PhD*, PSRD College of Rehabilitation Sciences

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

August 18, 2023

Primary Completion (Estimated)

December 29, 2024

Study Completion (Estimated)

December 31, 2024

Study Registration Dates

First Submitted

October 31, 2023

First Submitted That Met QC Criteria

May 9, 2024

First Posted (Actual)

May 14, 2024

Study Record Updates

Last Update Posted (Actual)

May 14, 2024

Last Update Submitted That Met QC Criteria

May 9, 2024

Last Verified

May 1, 2024

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • PSRDHospital

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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