Brain Lesion and Visuospatial Impairment in CP Child (EVSP-ANAT-CP)

Visuo-spatial Profile in Children with Cerebral Palsy Born At Term or Not and Anatomical Correlation

Children with cerebral palsy (CP) show varying degrees of motor impairment and movement disorders whose perceptive-visual contribution has yet to be established. The literature reports that children with CP have more frequent neuro-visual disorders. The link between the location and size of the brain lesion and neurovisual symptomatology has yet to be explored.

In this retrospective clinical data study, we will investigate in children with PC whether there is an anatomo-clinical correlation between visuo-spatial disorders is the brain injury of interest to the dorsal visual pathway. We will explore the volume of grey and white matter parietal involvement.

To test visuo-spatial disorders, we will use the PVSE (Visuo-Spatial Elementary Perception) test which does not require motor skills or language and is therefore suitable for children with a PC. This test will make it possible to better identify the deficit or deficits in order to adapt an early remediation. It could serve as a reference for comparing several pathologies/etiologies.

Study Overview

• Status: Completed
• Conditions: Children with Cerebral Palsy
• Intervention / Treatment: Diagnostic test: PVSE Test; Other: Cerebral MRI

• Study Type: Observational
• Enrollment (Actual): 150

Contacts and Locations

Study Locations

• France
  • Bron, France, 69677
    • Pediatric rehabilitation unit of the Hospices Civils de Lyon

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Children coming for out-patient consultation at the paediatric rehabilitation unit of the Hospices Civils de Lyon for a CP diagnosis

Description

Inclusion Criteria:

• Male or female aged 4 to 18 yo
• With a CP diagnosis
• With PVSE test completion during his/her regular follow-up
• With a cerebral MRI scan during his/her regular follow-up

Exclusion Criteria:

- With an incomplete PVSE test or whose interpretation was deemed unreliable by the rater

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
CP child	Diagnostic test: PVSE Test; Completion of the PVSE test; Other: Cerebral MRI; Cerebral MRI scan
CP child with a PVSE test and a cerebral MRI performed during his/her follow-up	Diagnostic test: PVSE Test; Completion of the PVSE test; Other: Cerebral MRI; Cerebral MRI scan

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
PVSE test results: total score and 8 sub-scores (length perception, size perception, angle comparison, midline localization, position perception, position selection, occipital score and parietal score.)	Using normative values of PVSE test, we assess pathological measure inferior outlier limits and subnormal measure below the lower quartile limit	At the inclusion

Collaborators and Investigators

• Sponsor: Hospices Civils de Lyon

Study record dates

Study Major Dates

• Study Start (Actual): September 1, 2022
• Primary Completion (Actual): December 31, 2023
• Study Completion (Actual): April 2, 2024

Study Registration Dates

• First Submitted: November 9, 2023
• First Submitted That Met QC Criteria: November 9, 2023
• First Posted (Actual): November 14, 2023

Study Record Updates

• Last Update Posted (Estimated): November 8, 2024
• Last Update Submitted That Met QC Criteria: November 7, 2024
• Last Verified: November 1, 2024

More Information

Terms related to this study

• Keywords: Cerebral Palsy, child, visuo-spatial disorder, brain lesion
• Additional Relevant MeSH Terms: Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Brain Damage, Chronic; Cerebral Palsy
• Other Study ID Numbers: 69HCL23_1053

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No