Relationship of Muscular Agenesis: Thin Plantar and Palmar Long as a Biomarker of Injury and Performance Marker in the Lower Limb and Upper Limb Respectively (MA-TP-PL)

June 3, 2024 updated by: JJ JIMENEZ-REJANO, University of Seville
This study investigates muscle agenesis, specifically the absence of the palmaris longus and plantaris muscles, and its effects on injury risk, strength, and performance. Muscle injuries are common in sports, and the presence or absence of certain muscles can impact biomechanics and injury susceptibility. The study involves 132 subjects, divided into those with and without muscle agenesis, assessing injuries with the Nordic and CMDQ questionnaires and measuring strength with dynamometers. Results aim to clarify the controversial impact of muscle agenesis on functional disability and performance adaptation in the scientific literature.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

Background. This study examines muscle agenesis, a congenital condition that involves the absence of a muscle, focusing on the palmaris longus and plantaris muscles. The prevalence of palmaris longus agenesis varies significantly, and there is debate about whether its absence results in functional disability or is a predictor of injuries. Muscle injuries account for one-third of sports injuries and more than 30% of all musculoskeletal system injuries. The presence or absence of certain muscles can influence the body's biomechanics and, therefore, susceptibility to injuries, as muscles play a crucial role in generating force and coordination, hence movement. The absence of certain muscles may require other muscles to compensate, which could affect the efficiency and performance capacity in certain body areas. However, in many cases, the absence of a muscle may not have a significant effect on performance, as other muscles can adapt to perform its function. This study seeks to provide clarity in this area of research due to the existing controversy in the scientific literature.

Objectives. To determine if muscle agenesis influences the development of injuries and its impact on strength and performance.

Material and methods. An observational analytical cross-sectional study was conducted with 132 subjects divided into one group of 66 subjects with muscle agenesis and another group of 66 subjects without muscle agenesis. The primary variable is the presence of upper and lower limb injuries measured using the Nordic and CMDQ questionnaires, and the secondary variable is upper limb strength measured with a dynamometer in palmar flexion and hand grip tests; and lower limb strength measured with a dynamometer in plantar flexion and vertical jump tests. The measurements were taken over 1 hour and 30 minutes during two days, with a 48-hour interval between the measurements of the upper and lower limbs.

Study Type

Observational

Enrollment (Estimated)

132

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

  • Name: Jose-Jesus Jimenez-Rejano, PhD
  • Phone Number: +34667309369
  • Email: jjjimenez@us.es

Study Locations

  • Spain
    • Madrid
      • Alcalá De Henares, Madrid, Spain, 28804
        • Campus Científico-Tecnológico UAH. Av. de León, 3A, Alcalá de Henares, Madrid
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

People with and without muscle agenesis.

Description

Inclusion Criteria:

  • Individuals who lead a sedentary lifestyle or who are not used to doing physical training on a regular basis (more than 2 h/week).
  • People between 18 and 80 years old.

Exclusion Criteria:

  • Individuals with an ongoing oncological process.
  • People with an active infectious process.
  • Subjects with psychiatric disorders.
  • Individuals with intellectual disorders that prevent understanding of the intervention.
  • People with judicial incapacity.
  • Patients diagnosed with fibromyalgia.
  • Pregnancy or probability of pregnancy.
  • Individuals with sensory impairments in the hand that prevent manual pressure.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Agenesis Group
Subjects with the presence of muscular agenesis of the plantar muscle and palmaris longus.
Diagnostic test: Ultrasound
An ultrasound examination of the musculature of the plantar muscle and long palmar muscle is performed to determine their presence or absence.
Non-agenesis Group
Subjects without the presence of muscular agenesis of the plantar muscle and palmaris longus.
Diagnostic test: Ultrasound
An ultrasound examination of the musculature of the plantar muscle and long palmar muscle is performed to determine their presence or absence.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Presence of injury
Time Frame: At the start of the study (at baseline, 0 week).
Presence of injury related to the upper and lower limb.
At the start of the study (at baseline, 0 week).

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Strength
Time Frame: At the start of the study (at baseline, 0 week)
Upper and lower limb strength
At the start of the study (at baseline, 0 week)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Seville

Investigators

  • Principal Investigator: Alvaro Garcia-Luna, MSc, University of Alcala
  • Principal Investigator: Jose-Jesus Jimenez-Rejano, PhD, University of Seville

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

September 1, 2024

Primary Completion (Estimated)

December 31, 2024

Study Completion (Estimated)

January 31, 2025

Study Registration Dates

First Submitted

June 3, 2024

First Submitted That Met QC Criteria

June 3, 2024

First Posted (Actual)

June 7, 2024

Study Record Updates

Last Update Posted (Actual)

June 7, 2024

Last Update Submitted That Met QC Criteria

June 3, 2024

Last Verified

June 1, 2024

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Muscular Agenesis Thin plantar

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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