Gastrointestinal Bleeding and Atmospheric Pressure Relationship

The Effect of Atmospheric Pressure on Patients Presenting to the Emergency Department With Gastrointestinal Bleeding

This study aims to investigate whether atmospheric pressure has an effect on upper gastrointestinal bleeding (UGIB), which includes causes such as peptic ulcer disease, esophagitis, gastritis, gastrointestinal varices, Mallory-Weiss tears, and gastric cancer. The goal is to determine the impact of atmospheric pressure and gather information on its role in high-risk UGIB.

Study Overview

• Status: Recruiting
• Conditions: GastroIntestinal Bleeding; Atmospheric Pressure; Adverse Effect

Detailed Description

ur study aims to investigate the potential effects of changes in atmospheric pressure on gastrointestinal bleeding, and if such effects exist, to review treatment adjustments based on weather forecasts for hypertensive patients to prevent potential hypertensive emergencies and enhance patient comfort. This research poses no risk to patients and is purely observational and clinical in nature.

After initial evaluation upon presentation to the emergency department, patients will undergo routine emergency department monitoring for gastrointestinal bleeding, including physical examination, vital sign monitoring, evaluation of coagulation parameters, and hemoglobin levels. Apart from routine tests, no additional invasive or non-invasive procedures will be performed by us.

Obtained data from patients and atmospheric pressure data will be analyzed and evaluated. Results will be analyzed to determine any relation between gastrointestinal bleeding and atmospheric pressure changes

• Study Type: Observational
• Enrollment (Estimated): 250

Contacts and Locations

• Study Contact: Name: Gulsen AKCAY, Ass. Prof.; Phone Number: +905052874949; Email: gulakcay@yahoo.com.tr
• Study Contact Backup: Name: emre kagan unal, resident; Phone Number: +905443539793; Email: emrekaganunal@hotmail.com

Study Locations

• Turkey
  • Yenimahalle
    • Ankara, Yenimahalle, Turkey, 06170
      • Recruiting
      • Etlik city hospital
      • Contact: Gulsen AKCAY, Ass. Prof.; Phone Number: +905052874949; Email: gulakcay@yahoo.com.tr
      • Contact: emre kagan unal, resident; Phone Number: +905443539793; Email: emrekaganunal@hotmail.com
      • Sub-Investigator: emre kagan unal, resident
      • Sub-Investigator: ilker sirin, specialist
      • Sub-Investigator: hakan dogan, doctor
      • Principal Investigator: gulsen akcay, ass.prof.
      • Sub-Investigator: Bedriye Muge SONMEZ, ass.prof

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

Patients presenting to emergency department with gastrointestinal bleeding

Description

Inclusion criteria:

Patients aged 18 and above Patients presenting to the emergency department with complaints of gastrointestinal bleeding, whether active or resolved Patients willing to participate in the study Patients from central districts of Ankara

Exclusion criteria:

Patients under the age of 18 Pregnant individuals Patients with a history of trauma at the time of admission Patients declaring they are from a city other than Ankara

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
GI Bleeding; Patients administered to emergency department with GI bleeding will be scrrened and obtained retrospectively from hospital system. Atmospheric pressure data will be obtained from Meteorology Directorate. Patients' data will be evaluated according to atmospheric pressure values.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
gastrointestinal bleeding	patients administered to emergency department with gastrointestinal bleeding	24 hours

Collaborators and Investigators

• Sponsor: Saglik Bilimleri Universitesi
• Collaborators: Ankara Etlik City Hospital
• Investigators: Study Director: gulsen akcay, ass. prof., ass. prof. of organization

Publications and helpful links

General Publications

• Guo CG, Tian L, Zhang F, Cheung KS, Leung WK. Associations of seasonal variations and meteorological parameters with incidences of upper and lower gastrointestinal bleeding. J Gastroenterol Hepatol. 2021 Dec;36(12):3354-3362. doi: 10.1111/jgh.15632. Epub 2021 Jul 30.
• Prechter F, Burger M, Lehmann T, Stallmach A, Schmidt C. A study on the correlation of gastrointestinal bleeding and meteorological factors - is there a weather condition for GI bleeding? Z Gastroenterol. 2019 Dec;57(12):1476-1480. doi: 10.1055/a-1008-9863. Epub 2019 Dec 11.
• Lenzen H, Musmann E, Kottas M, Schonemeier B, Kohnlein T, Manns MP, Lankisch TO. Acute gastrointestinal bleeding cases presenting to the emergency department are associated with age, sex and seasonal and circadian factors. Eur J Gastroenterol Hepatol. 2017 Jan;29(1):78-83. doi: 10.1097/MEG.0000000000000752.

Study record dates

Study Major Dates

• Study Start (Actual): April 5, 2024
• Primary Completion (Estimated): November 5, 2024
• Study Completion (Estimated): November 5, 2024

Study Registration Dates

• First Submitted: July 17, 2024
• First Submitted That Met QC Criteria: July 17, 2024
• First Posted (Actual): July 23, 2024

Study Record Updates

• Last Update Posted (Actual): July 23, 2024
• Last Update Submitted That Met QC Criteria: July 17, 2024
• Last Verified: July 1, 2024

More Information

Terms related to this study

• Keywords: emergency department; gastrointestinal bleeding; atmospheric pressure
• Additional Relevant MeSH Terms: Digestive System Diseases; Pathologic Processes; Gastrointestinal Diseases; Hemorrhage; Gastrointestinal Hemorrhage
• Other Study ID Numbers: GIB and Atmospheric Pressure

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No