The Effect of Cryostimulation on Inflammation and Motor Functions. The Study Was Conducted to Determine the Effect of Five Days of Whole-body Cryostimulation (PBC) on Reducing Inflammation and Improving Motor Skills in Soccer Players

January 15, 2025 updated by: Poznan University of Physical Education

The Influence of Cryostimulation on Reducing Inflammation and Improving Motor Skills in Football Player

The aim of the study was to determine the effect of a 5-day PBC on reducing inflammation and improving motor skills in soccer players during the initial phase of the training period.

The five-day cryostimulation applied did not significantly affect the profile of inflammatory markers in soccer players. However, a reduction in visuo-motor reaction time (RT) was registered in PBC-treated soccer players, suggesting the potential benefits of this method in improving motor skills.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Cryostimulation is one of the methods of post-exercise recovery, involving short-term (3 min) exposure of the body to extremely low temperatures, oscillating between -100°C and -190°C. The purpose of this therapy is to reduce inflammation, reduce physical and mental fatigue and use it as a passive form of preparing the body for further exercise as part of the training process.

The study was conducted to determine the effect of five days of whole-body cryostimulation (PBC) on reducing inflammation and improving motor skills in soccer players. A group of 24 football players was randomly divided into a test group (PBC; -140°C ± 20°C, 3 min, 5 days) and a control group (CON). Before the cryostimulation session, both groups were subjected to visual-motor ability tests, which were repeated on the last day of the study. Blood samples were collected at four time points (P0-1 day, P1-3 day, P2-5 day, P3-2 days after the test). Levels of creatine kinase (CK), tumor necrosis factor (TNFα), interleukins (IL-6, IL-10), testosterone (T) and cortisol (C) were determined in the samples.

Study Type

Interventional

Enrollment (Actual)

21

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Poland
      • Poznań, Poland, 61-871
        • Poznan University of Physical Education

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • athletes
  • no previous experience with systemic cryotherapy
  • any other forms of recovery or cosmetic treatments

Exclusion Criteria:

  • alcohol or any other stimulants
  • anti-inflammation drugs
  • injuries

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Cryostimulation
Cryostimulation performed in a cryosauna for five consecutive days.
Other: Criostymulation

Method: Cryosauna. Temperature: -160°C. Duration: 5 days. Session Timing: 9:00 a.m.

Session Length: 3 minutes per day

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
IL-6 (Interleukin-6)
Time Frame: Before, after 3 days and 5 days of cryostimulation
Immunoenzymatic assay method using a diagnostic ELISA Kit
Before, after 3 days and 5 days of cryostimulation
TNF-alpha (Tumor necrosis factor-alpha)
Time Frame: Before, after 3 days and 5 days of cryostimulation
Immunoenzymatic assay method using a diagnostic ELISA Kit
Before, after 3 days and 5 days of cryostimulation
IL-10 (Interleukin-10)
Time Frame: Before, after 3, and 5 days of cryostimulation
Immunoenzymatic assay method using a diagnostic ELISA Kit
Before, after 3, and 5 days of cryostimulation
CK (creatine kinase)
Time Frame: Before, after 3, and 5 days of cryostimulation
Immunoenzymatic assay method using a diagnostic ELISA Kit
Before, after 3, and 5 days of cryostimulation
Cortisol
Time Frame: Before, after 3, and 5 days of cryostimulation
Immunoenzymatic assay method using a diagnostic ELISA Kit
Before, after 3, and 5 days of cryostimulation
Testosterone
Time Frame: Before, after 3, and 5 days of cryostimulation
Immunoenzymatic assay method using a diagnostic ELISA Kit
Before, after 3, and 5 days of cryostimulation

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Anthropometric measurments
Time Frame: Before, after 3, and 5 days of cryostimulation
Analysis of body composition, Tanita BC-418
Before, after 3, and 5 days of cryostimulation

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Poznan University of Physical Education

Investigators

  • Principal Investigator: Izabela Różycka, Poznan University of Physical Education

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 25, 2023

Primary Completion (Actual)

February 24, 2024

Study Completion (Actual)

April 15, 2024

Study Registration Dates

First Submitted

July 24, 2024

First Submitted That Met QC Criteria

August 8, 2024

First Posted (Actual)

August 12, 2024

Study Record Updates

Last Update Posted (Actual)

March 25, 2025

Last Update Submitted That Met QC Criteria

January 15, 2025

Last Verified

July 1, 2024

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Kriokomora 845/22
  • 12622001541796 (Registry Identifier: ANZCTR of Australia and New Zealand)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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