Hainan Community Cognition Cohort

A Prospective Cohort of Hainan Community Elderly Population with Cognitive Impairment

This is a community-based prospective cohort study in Hainan Province, China. The study was initialized in 2023 and included older residents for longitudinal follow-up. The research aims to identify risk factors as well as health and social outcomes that are associated with cognitive impairment in elderly populations, and independently develop AI-assisted software and applications for cognitive enhancement and physical rehabilitation training.

Study Overview

• Status: Recruiting
• Conditions: Cognitive Impairment; Dementia; Age Problems
• Intervention / Treatment: Other: No Intervention: Observational Cohort

Detailed Description

This is a community-based prospective cohort study in Hainan Province, China. Subjects are individuals aged 60 years and above who have lived in the communities for more than six months and have signed informed consent. The research have been initialed in 2023 and aims to identify the risk factors associated with cognitive impairment, to develop software for cognitive enhancement and physical rehabilitation training. The study includes three steps: first, to conduct cognitive function screening in 16 communities in four districts (Xiuying, Meilan, Longhua, and Qiongshan) of Haikou City and establish a database for the elderly in tropical regions; second, to identify risk factors associated with cognitive impairment in the elderly population; finally, to independently develop a software for cognitive function enhancement and physical rehabilitation training.

• Study Type: Observational
• Enrollment (Estimated): 2000

Contacts and Locations

• Study Contact: Name: Jindong Ding Petersen, PHD.; Phone Number: 089866893772; Email: dingjindong@muhn.edu.cn

Study Locations

• China
  • Hainan
    • Haikou, Hainan, China, 571199
      • Recruiting
      • Hainan Medical University
      • Contact: Jindong Ding Petersen, PHD; Phone Number: +8613256406001; Email: dingjindong@muhn.edu.cn

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Community residents aged 60 years or older in Hainan Province, China

Description

• Inclusion Criteria:

  • Age 60 years and above
  • Lived in the community for more than 6 months
  • Signed the informed consent form

• Exclusion Criteria:

  • Cannot complete the survey

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The prevalence and incidence of cognitive impairment base on the communities	Mild cognitive impairment was measured using a Chinese version Mini-Mental State Examination, which was collected by questionnaire. The minimum value of the Mini-Mental State Examination is 0, and the maximum value is 30, the higher the score, the better the cognition outcome.	An average of 1 to 2 years
The prevalence and incidence of dementia using a population-based survey	Dementia was determined by diagnosis of hospitalization or Clinical Dementia Rating Scale (Montreal Cognitive Assessment, MoCA). The minimum value of the MoCA is 0, and the maximum value is 30, the higher the score, the better the outcome. In addition, subtypes of dementia will be based on the specific clinical diagnosis.	An average of 1 to 2 years
The conversion rate of normal to cognitive impairment	Percentage of enrolled population that convert from normal to cognitive impairment	An average of 1 to 2 years
The conversion rate of cognitive impairment to dementia	Percentage of enrolled population that convert from cognitive impairment to dementia	An average of 1 to 2 years

Collaborators and Investigators

• Sponsor: Hainan Medical College
• Collaborators: Fudan University; Xuanwu Hospital, Beijing; The Second Affiliated Hospital of Hainan Medical University

Study record dates

Study Major Dates

• Study Start (Actual): December 16, 2022
• Primary Completion (Estimated): December 31, 2053
• Study Completion (Estimated): December 31, 2053

Study Registration Dates

• First Submitted: October 23, 2024
• First Submitted That Met QC Criteria: November 11, 2024
• First Posted (Estimated): November 13, 2024

Study Record Updates

• Last Update Posted (Estimated): November 13, 2024
• Last Update Submitted That Met QC Criteria: November 11, 2024
• Last Verified: September 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Mental Disorders; Neurocognitive Disorders; Cognition Disorders; Cognitive Dysfunction
• Other Study ID Numbers: Hainan Medical University; ZDYF2024SHFZ064 (Other Grant/Funding Number: Hainan Provincial Department Of Science and Technology); 82360673 (Other Grant/Funding Number: National Natural Science Foundation of China); XRC2022005 (Other Grant/Funding Number: Hainan Medical University)

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No