Investigating the Efficacy of OMT to Recover Olfactory Perception After COVID-19

January 8, 2025 updated by: Thomas Eiting, Burrell College of Osteopathic Medicine
One of the most widespread symptoms of COVID-19 is loss of the sense of smell. There are very few treatments for helping individuals recover their sense of smell. Osteopathic manipulative treatment (OMT) may be a useful tool in helping people recover their smell perception. In this study the investigators test whether OMT can be used to help individuals recover their sense of smell if they lost it during COVID-19.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

Objectives: The objective of this study is to determine if osteopathic manipulative treatment affects the sense of smell after COVID-19 infection. A secondary objective of this study is to determine how long the improvement in the sense of smell lasts.

Background and Hypothesis: One of the most widespread symptoms of COVID-19 is the substantial reduction (hyposmia) or complete loss of the sense of smell (anosmia) in affected individuals. Individuals who experience loss of smell report reductions in many metrics of quality of life (e.g., enjoyment of coffee or food), as well as facing a slight elevated risk of serious, life-threatening scenarios (e.g., delayed detection of smoke from fire). Some people who experience loss of smell experience a complete recovery concomitant with overall COVID-19 recovery. More commonly, however, is some degree of persistent loss of smell. In extreme cases individuals lose their sense of smell completely or retain only the most rudimentary of sensory abilities. Additionally, partial or complete loss of smell has emerged as an early and common symptom of Alzheimer's disease and other dementias, including dementias associated with Parkinson's disease. Whether the loss of smell from infections or allergies contributes to the risk of developing these conditions is unknown. The treatment for anosmia ranges from intranasal budesonide to stellate ganglion blockade. Little has been published regarding the use of osteopathic manipulative treatment (OMT) to treat anosmia in post-COVID-19 patients. The techniques that have been employed are advanced skills that few osteopathic physicians possess.

In this project, the investigators explore the possibility of employing (OMT) to help individuals recover some or all of their olfactory ability after a COVID-19 infection. The investigators will employ techniques that are commonly used in OMT to alleviate symptoms associated with sinusitis or other complaints associated with the nasal sinuses and airway. Specifically, the investigators have chosen to investigate the use of occipitoatlantal decompression and treatment of the Chapman nose point in providing relief from COVID-19 symptoms, because of their effectiveness in OMT for other nasal-related diseases or infections, their relative ease of use and of teaching to osteopathic medical students, who will be recruited as student investigators to contribute to this study and future studies for which the current proposal is laying the groundwork.

Study Subjects: All subjects will be adult (minimum age of 18 years) individuals of both genders who have tested positive for COVID-19. After an initial screening of their sense of smell, subjects who are found to have a normal odor identification ability will be excluded from the study.

Recruitment of Subjects: Subjects will be recruited from the Las Cruces community by word of mouth, as well as through the use of a simple flyer that will be generated and passed out to community members and posted on public message boards. The investigators will work with the Burrell College Office of Marketing and Public Relations to further devise a strategy for recruiting participants.

Number of Subjects: 32

Power Analysis: Please see Item 7.

Inclusion criteria: Minimum of 18 years of age, verified by an official picture ID, positive COVID-19 test with recent COVID-19 symptoms.

Exclusion criteria: Age under 18 years; pregnancy; any findings on the osteopathic screening/evaluation that would hinder the effectiveness or increase the risk associated with OA decompression; any medication that interferes with the sense of smell (intranasal zinc, intranasal antihistamines, intranasal corticosteroids), allergic rhinitis, use of oral corticosteroids, antihistamines.

Consent and Enrollment: Prior to enrollment in the study, potential subjects will review the purpose of the study, eligibility for inclusion in the study (based on exclusion criteria listed above), potential risks and benefits, and the consent form with one of the researchers. Once written consent is obtained, the subjects will be asked to fill out a questionnaire that is designed to verify that the subject qualifies for inclusion in the study (based on exclusion criteria) and to obtain contact data (name, address, phone, e-mail) and demographic information (age, sex). Potential subjects may be excluded based on answers in the questionnaire. Each subject will be assigned a subject number that will be used to de-identify data.

Consent will also be obtained from the PI, co-PI, and student investigators as there is a possible risk of contracting COVID-19 despite wearing masks. Vaccination against COVID-19 will be recommended.

Study Subjects:

Decision on enrollment: The final decision on enrollment based on these criteria will be done by the PI, Dr. Eiting or the co-investigator, Dr. Kania.

Experimental Protocol: The general procedure for this study is as follows. The investigators will recruit subjects with and without a current COVID-19 infection, and ask them to undergo an olfactory behavioral test to determine their current olfactory acuity. Subjects with current COVID-19 infection will have evidence of a positive test, and will be evaluated not sooner than the sixth day of symptoms. The New Mexico Department of Health recommends quarantining for five days after the onset of symptoms of Covid infection. Investigators and subjects will wear masks covering their nose and mouth during evaluation and undergoing the interventions. After consent is obtained, subjects will be randomly assigned to the treatment or sham arms of the study. All subjects will undergo evaluation of their sense of smell via an olfactory test. The investigators will use the "Sniffin' Sticks" olfactory test, which has been validated and utilized in many scientific studies. The testing will be done in an open-air, well-ventilated room on the Burrell main campus. Subjects will then undergo OMT intervention or sham treatment (participants will not know to which group they are assigned), and their olfactory acuity will be tested again, post-intervention. An interval of at least one hour will be used between pre- and post-treatment olfactory testing. Subjects will be invited back to undergo olfactory testing again on a daily basis for up to 10 days. This is to determine the effectiveness of a single OMT intervention and how long the effect lasts, or the rate of spontaneously returned sense of smell.

The OMT intervention in this study will be comprised of an occipitoatlantal (OA) decompression and treatment of the nasal Chapman point. The OA decompression will be applied for 2 minutes with 12N of pressure as this pressure has been determined to produce the greatest effect. Treatment at this level reduces congestion of nasal mucosa. The suboccipital decompression technique is generally considered to bear minimal risks and is perceived by most patients as a pleasant experience. This technique is considered to be a basic skill among osteopathic physicians. It is usually taught within the first semester of the first year at Colleges of Osteopathic Medicine. There has been no untoward effects on students performing or receiving this technique in the fourteen years that the PI has taught the technique at BCOM or RVU-COM. She has not had any patients have adverse reactions to this technique during the nearly thirty years she was in practice.

The other intervention technique will be addressing the nasal Chapman points that are found at the tip of the transverse process of C1 and the costochondral junction of the first rib on each side. These techniques are safe and easily performed. Dr. Kania has extensive experience in teaching these techniques and training osteopathic medical students to perform them consistently for various studies.12 Both techniques are performed while the subject is supine.

Osteopathic manipulation is well-tolerated in general according to a study by Degenhardt et al., that found that only 45 out of 1847 visits for osteopathic manipulative treatment resulted in pain or discomfort, tiredness, fatigue, lightheadedness, nausea/vomiting, headache, numbness/tingling or stiffness following osteopathic treatment.

The sham intervention will consist of the subject lying supine with the investigator's hands resting gently on both sides of subject's neck for 5 minutes.

Study Type

Interventional

Enrollment (Estimated)

32

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • United States
    • New Mexico
      • Las Cruces, New Mexico, United States, 88001
        • Recruiting
        • Burrell College of Osteopathic Medicine
        • Contact:
        • Contact:
          • Thomas P Eiting, Ph.D

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Positive COVID-19 test or diagnoses
  • Self-reported deficiency in sense of smell

Exclusion Criteria:

  • Age under 18 years
  • Pregnancy
  • Any findings on the osteopathic screening/evaluation that would hinder the effectiveness or increase the risk associated with OA decompression
  • Any medication that interferes with the sense of smell (intranasal zinc, intranasal antihistamines, intranasal corticosteroids)
  • Allergic rhinitis
  • Use of oral corticosteroids or antihistamines.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: OMT
Subjects will undergo an evaluation of their sense of smell using a thoroughly-vetted and published protocol. If subjects are found to have a reduced sense of smell, they will be assigned to either the OMT or sham intervention. The OMT intervention will consist of two procedures: occipitoatlantal decompression and treating the nasal Chapman point. Subjects will then be evaluated after receiving treatment, as well as a follow-up visit the day after, and a final visit within 1-2 weeks post treatment.
Procedure: Osteopathic Manipulative Treatment

The OMT intervention in this study will be comprised of an occipitoatlantal (OA) decompression and treatment of the nasal Chapman point. The OA decompression will be applied for 2 minutes with 12N of pressure as this pressure has been determined to produce the greatest effect. Treatment at this level reduces congestion of nasal mucosa. The suboccipital decompression technique is generally considered to bear minimal risks and is perceived by most patients as a pleasant experience. This technique is considered to be a basic skill among osteopathic physicians. It is usually taught within the first semester of the first year at Colleges of Osteopathic Medicine.

The other intervention technique will be addressing the nasal Chapman points that are found at the tip of the transverse process of C1 and the costochondral junction of the first rib on each side. Both techniques are performed while the subject is supine.
Sham Comparator: Sham
Subjects will undergo an evaluation of their sense of smell using a thoroughly-vetted and published protocol. If subjects are found to have a reduced sense of smell, they will be assigned to either the OMT or sham intervention. The sham intervention will consist of the experimenter resting their hands on the sides of the subject's neck. Subjects will then be evaluated after receiving treatment, as well as a follow-up visit the day after, and a final visit within 1-2 weeks post treatment.
Procedure: Sham treatment
The sham intervention will consist of the subject lying supine with the investigator's hands resting gently on both sides of subject's neck for 5 minutes.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Ability to Recover Sense of Smell after OMT
Time Frame: from enrollment until 2 weeks post treatment
Data from 32 COVID-19-positive individuals will be collected. This group will be divided into 2 groups of 16: one of these groups will be given the OMT intervention, and one will be given a sham intervention. The sample size of 16 per group comes about as follows. The main dependent variable measured for each person will be the number of odors identified out of a panel of 16 odors. This will be in the form of a multiple-forced-choice questionnaire: participants will be required to identify the odor from a selection of possible options. Upon treatment and re-testing, we will measure the number of odors identified again. Previous work (Whitcroft et al. 2016, Rhinology 54:368-373) that has looked at the effects of sodium citrate treatment on odor identification ability has shown a mean improvement of just over 2 points using this same identification test (for example, subjects able to correctly identify 14 odors posttreatment and just 12 odors pre-treatment).
from enrollment until 2 weeks post treatment

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Burrell College of Osteopathic Medicine

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

August 29, 2024

Primary Completion (Estimated)

August 1, 2025

Study Completion (Estimated)

August 1, 2025

Study Registration Dates

First Submitted

January 3, 2025

First Submitted That Met QC Criteria

January 8, 2025

First Posted (Actual)

March 25, 2025

Study Record Updates

Last Update Posted (Actual)

March 25, 2025

Last Update Submitted That Met QC Criteria

January 8, 2025

Last Verified

January 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 0118_2023

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

An explicit plan to share these data has not been developed. We will share deidentified data as required by any journal in which we may publish the data collected for this project. We may revisit this plan in the future.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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