Hypertension, Ethnicity and Exercise Trial (HYPE2X)

The main aim of this study is to investigate the acute effects of a single bout of isometric handgrip exercise (IHG) and a single bout of aerobic endurance exercise (AEX) on blood pressure, both immediately after exercise and during the subsequent activities of daily living in patients with high-normal to grade 1 hypertension of South-Asian or African descent living in Suriname.

Study Overview

• Status: Completed
• Conditions: Hypertension
• Intervention / Treatment: Behavioral: Exercise

• Study Type: Interventional
• Enrollment (Actual): 60
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Suriname
  • Paramaribo, Suriname
    • Anton De Kom University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• • Age 18 - 65 years

  • Patients with high- normal BP (SBP: 130 - 139 mmHg or and DBP: 85 - 89 mmHg) or stage I hypertension (SBP: 140 - 159 mmHg or DBP: 90 - 99 mmHg) according to the ESC/ESH guidelines [15]
  • Asian or African descent
  • Do not meet the level of physical activity recommended by the WHO based on self-report [15]
  • Non-medicated patients or patients using a maximum of 2 antihypertensive drugs

Exclusion Criteria:

• • Functional or mental limitation limiting the correct execution of an exercise bout

  • History of ischemic stroke, autonomic neuropathy, cardiovascular, renal, or pulmonary disease by self-report
  • Diabetes type I or II
  • Pregnancy
  • The presence of exercise induced signs of myocardial ischemia or complex ventricular arrhythmia during CPET
  • Patients using three or more antihypertensive drugs or patients with resistant hypertension

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Single

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: isometric handgrip exercise; 4x2 minutes of isometric handgrip exercise	Behavioral: Exercise; aerobic exercise for 30 minutes at 40-60% HRres
No Intervention: control; seated control session
Experimental: Aerobic exercise; aerobic exercise at 40-60% HRres	Behavioral: Exercise; aerobic exercise for 30 minutes at 40-60% HRres

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
office blood pressure at 30 minutes post exercise	office blood pressure at 30 minutes post exercise	30 minutes postexercsie

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
daytime blood pressure	daytime ambulatory blood pressure (8 hours after the intervention)	mean of 8 hours after the intervention

Collaborators and Investigators

• Sponsor: KU Leuven

Study record dates

Study Major Dates

• Study Start (Actual): June 1, 2020
• Primary Completion (Actual): November 30, 2023
• Study Completion (Actual): November 30, 2023

Study Registration Dates

• First Submitted: February 10, 2025
• First Submitted That Met QC Criteria: February 10, 2025
• First Posted (Actual): March 25, 2025

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: February 10, 2025
• Last Verified: February 1, 2025

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Vascular Diseases; Cardiovascular Diseases; Hypertension
• Other Study ID Numbers: 183/2020

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No