Impact of Perioperative Nutritional Status and Management in the Context of Resectable Pancreatic Adenocarcinoma (PAAD)

March 24, 2025 updated by: University Hospital, Strasbourg, France

Patients with pancreatic adenocarcinoma are frequently in a situation of malnutrition, in a context of functional alteration of the digestive tract, and hypercatabolism.

As a result, nutritional support is frequently necessary perioperatively, but currently does not follow a specific protocol, and without coordination.

It then appears the need to evaluate the prevalence of malnutrition, its impact on perioperative morbidity and mortality, and current management methods.

Depending on the findings, subsequent interventional studies will be carried out on the subject, exploring the different modalities of artificial nutrition.

Study Overview

Status

Recruiting

Conditions

Pancreatic Adenocarcinoma

Study Type

Observational

Enrollment (Estimated)

100

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: Zineb CHERKAOUI, MD
Phone Number: 33 3 69 55 13 15
Email: zineb.cherkaoui@chru-strasbourg.fr

Study Locations

France
- - Strasbourg, France, 67091
    - Recruiting
    - Service de Chirurgie Viscérale et Digestive - CHU de Strasbourg - France
    - Contact:
      
      Zineb CHERKAOUI, MD
      
      Phone Number: 33 3 69 55 13 15
      
      Email: zineb.cherkaoui@chru-strasbourg.fr
    - Principal Investigator:
      
      Zineb CHERKAOUI, MD
    - Sub-Investigator:
      
      Arne KOCK, MD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

Adult
Older Adult

Accepts Healthy Volunteers

N/A

Sampling Method

Non-Probability Sample

Study Population

Major subject (≥18 years old) with pancreatic adenocarcinoma authenticated by pathology and operated on in the visceral and digestive surgery department, NHC Strasbourg, during the period from January 1, 2018 to December 31, 2022

Description

Inclusion Criteria:

Major subject (≥18 years old)
Subject with pancreatic adenocarcinoma authenticated by pathology
Subject candidate for curative surgical treatment
Subject operated on in the visceral and digestive surgery department, NHC Strasbourg, during the period from January 1, 2018 to December 31, 2022
Absence of written opposition in the subject's medical file to the reuse of their data for scientific research purposes.

Exclusion criteria:

Subject having expressed opposition to participating in the study
Subject presenting a metastatic form or one not accessible to surgical treatment considered curative of pancreatic adenocarcinoma
Subject under guardianship or curatorship
Subje

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Study of the Severity of Perioperative Malnutrition in Pancreatic Adenocarcinoma Time Frame: Up to 1 year	The CCI score measures a patient's postoperative outcome based on the number and severity of complications occurring on a scale of 0 to 100: 0: No complications 100: Death	Up to 1 year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospital, Strasbourg, France

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

October 12, 2023

Primary Completion (Estimated)

October 1, 2025

Study Completion (Estimated)

October 12, 2025

Study Registration Dates

First Submitted

July 4, 2024

First Submitted That Met QC Criteria

March 24, 2025

First Posted (Actual)

March 25, 2025

Study Record Updates

Last Update Posted (Actual)