The Severity Assessment Model for AECOPD With Combination of Disease and Syndrome

Construction and Evaluation of the Severity Assessment Model for AECOPD With Combination of Disease and Syndrome Based on Machine Learning

The establishment of the AECOPD severity assessment model can quickly and accurately evaluate the condition, which is of great significance for standardizing diagnosis and treatment, improving efficacy, and improving prognosis. At the same time, it can provide ideas and methods for the research of disease assessment models in related fields.

Study Overview

• Status: Not yet recruiting
• Conditions: Acute Exacerbation of Chronic Obstructive Pulmonary Disease
• Intervention / Treatment: Diagnostic test: Diagnosis and Severity Grading of AECOPD Disease

Detailed Description

Accurate assessment of the condition is the prerequisite and basis for standardized clinical treatment. Traditional Chinese medicine has shown good efficacy and advantages in treating AECOPD, but currently there is no ideal standard for judging the severity, nor is there an accurate, practical, and TCM specific disease assessment tool. Therefore, this project integrates multidimensional variables of traditional Chinese and Western medicine, and intends to conduct research on the construction of a disease syndrome combined AECOPD disease assessment model through literature review, expert consultation, clinical investigation, and machine learning algorithms, and establish preliminary grading standards for the severity of AECOPD disease. Ultimately, it provides ideas and methods for the rapid and accurate assessment of AECOPD, standardized diagnosis and treatment, improved efficacy, improved prognosis, and research on disease assessment models in related fields.

• Study Type: Observational
• Enrollment (Estimated): 1500

Contacts and Locations

• Study Contact: Name: Hailong H Zhang, doctor; Phone Number: +86-0371-66248624; Email: zhanghailong6@126.com

Study Locations

• China
  • Henan
    • Zhengzhou, Henan, China, 450000
      • The First Affiliated Hospital of Henan University of Traditional Chinese Medicine
      • Contact: Hailong H Zhang, doctor; Phone Number: +86-0371-66248624; Email: zhanghailong6@126.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Description

Inclusion Criteria:

• Meets AECOPD diagnostic criteria.
• Voluntarily participate in the research and sign the consent form

Exclusion Criteria:

• Individuals with severe mental disorders and cognitive impairments who are unable to communicate normally

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
AECOPD Patients	Diagnostic test: Diagnosis and Severity Grading of AECOPD Disease; Diagnosis and severity grading of AECOPD disease, as well as assessment of traditional Chinese medicine syndromes

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Clinical Investigation Questionnaire on Influencing Factors of the Severity of AECOPD	The influencing factors of the severity of AECOPD were evaluated through clinical investigation questionnaires. Questionnaire Title: Clinical Investigation Questionnaire on Influencing Factors of AECOPD Severity. The questionnaire adopts the scoring method, which is divided into "very unimportant", "not important", "average", "important" and "very important", and the corresponding values are assigned as 1, 2, 3, 4 and 5 respectively.The higher the score is, the more significant the result is.	24 hours

Collaborators and Investigators

• Sponsor: Henan University of Traditional Chinese Medicine
• Collaborators: Henan Provincial People's Hospital; The First Affiliated Hospital of Henan University of Traditional Chinese Medicine; Jiangsu province hospital of TCM; Third Affiliated Hospital of Henan University of Traditional Chinese Medicine; Qingdao Traditional Chinese Medicine Hospital(Qingdao Hiser Hospital); Xiangyang Traditional Chinese Medicine Hospital; Yanshi People's Hospital of Luoyang City; Shangcai County Traditional Chinese Medicine Hospital

Study record dates

Study Major Dates

• Study Start (Estimated): April 1, 2025
• Primary Completion (Estimated): December 31, 2028
• Study Completion (Estimated): December 31, 2028

Study Registration Dates

• First Submitted: January 27, 2025
• First Submitted That Met QC Criteria: April 6, 2025
• First Posted (Actual): April 9, 2025

Study Record Updates

• Last Update Posted (Actual): April 11, 2025
• Last Update Submitted That Met QC Criteria: April 9, 2025
• Last Verified: April 1, 2025

More Information

Terms related to this study

• Keywords: Artificial Neural Network; Acute Exacerbation of Chronic Obstructive Pulmonary Disease; Severity Assessment Model; Combination of Disease and Syndrome; Classification and Regression Trees
• Additional Relevant MeSH Terms: Pathologic Processes; Chronic Disease; Disease Attributes; Respiratory Tract Diseases; Lung Diseases; Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive
• Other Study ID Numbers: Model for AECOPD

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No