Nicotine and Cannabis Vape Labeling Experiment - Spring 2025 (EPIC/ADVANCE)

May 21, 2026 updated by: Adam Leventhal, University of Southern California

Longitudinal Patterns of Non-Combustible Tobacco Product Use in Adolescents (EPIC) / Assessing Development Patterns of Vaping, Alcohol, Nicotine, and Cannabis Use and Emotional Well-being (ADVANCE)

This study assesses how the ways in which nicotine and cannabis vaping devices are labeled impact use susceptibility, anticipated effects, and health harm.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The primary objectives of the study: (1) Determine whether different device labels with the contained substance (nicotine or cannabis) affect adolescent use susceptibility, anticipated effects or impairment, and perceived health harms; (2) Determine whether device color/product flavor differentially impact the study outcomes.

Study Type

Interventional

Enrollment (Actual)

3048

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • California
      • Los Angeles, California, United States, 90032
        • University of Southern California

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Participants must be enrolled in a partnering high school.

Exclusion Criteria:

  • Participants who cannot independently understand study consent and the study surveys are ineligible.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Mint - Labeling Condition 1
Participants will view an image of a mint-colored and flavored vape with label condition 1.
Other: Vaping Device Labeling

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.

The label conditions are:

  1. plain (i.e., no labeling on device)
  2. "contains THC"
  3. "contains 80% THC"
  4. "contains 80% THC - HIGH POTENCY"
  5. "contains nicotine"
  6. "contains 5% nicotine"
  7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.
Experimental: Mint - Labeling Condition 2
Participants will view an image of a mint-colored and flavored vape with label condition 2.
Other: Vaping Device Labeling

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.

The label conditions are:

  1. plain (i.e., no labeling on device)
  2. "contains THC"
  3. "contains 80% THC"
  4. "contains 80% THC - HIGH POTENCY"
  5. "contains nicotine"
  6. "contains 5% nicotine"
  7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.
Experimental: Mint - Labeling Condition 3
Participants will view an image of a mint-colored and flavored vape with label condition 3.
Other: Vaping Device Labeling

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.

The label conditions are:

  1. plain (i.e., no labeling on device)
  2. "contains THC"
  3. "contains 80% THC"
  4. "contains 80% THC - HIGH POTENCY"
  5. "contains nicotine"
  6. "contains 5% nicotine"
  7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.
Experimental: Mint - Labeling Condition 4
Participants will view an image of a mint-colored and flavored vape with label condition 4.
Other: Vaping Device Labeling

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.

The label conditions are:

  1. plain (i.e., no labeling on device)
  2. "contains THC"
  3. "contains 80% THC"
  4. "contains 80% THC - HIGH POTENCY"
  5. "contains nicotine"
  6. "contains 5% nicotine"
  7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.
Experimental: Mint - Labeling Condition 5
Participants will view an image of a mint-colored and flavored vape with label condition 5.
Other: Vaping Device Labeling

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.

The label conditions are:

  1. plain (i.e., no labeling on device)
  2. "contains THC"
  3. "contains 80% THC"
  4. "contains 80% THC - HIGH POTENCY"
  5. "contains nicotine"
  6. "contains 5% nicotine"
  7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.
Experimental: Mint - Labeling Condition 6
Participants will view an image of a mint-colored and flavored vape with label condition 6.
Other: Vaping Device Labeling

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.

The label conditions are:

  1. plain (i.e., no labeling on device)
  2. "contains THC"
  3. "contains 80% THC"
  4. "contains 80% THC - HIGH POTENCY"
  5. "contains nicotine"
  6. "contains 5% nicotine"
  7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.
Experimental: Mint - Labeling Condition 7
Participants will view an image of a mint-colored and flavored vape with label condition 7.
Other: Vaping Device Labeling

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.

The label conditions are:

  1. plain (i.e., no labeling on device)
  2. "contains THC"
  3. "contains 80% THC"
  4. "contains 80% THC - HIGH POTENCY"
  5. "contains nicotine"
  6. "contains 5% nicotine"
  7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.
Experimental: Original - Labeling Condition 1
Participants will view an image of a white colored and original vape with label condition 1.
Other: Vaping Device Labeling

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.

The label conditions are:

  1. plain (i.e., no labeling on device)
  2. "contains THC"
  3. "contains 80% THC"
  4. "contains 80% THC - HIGH POTENCY"
  5. "contains nicotine"
  6. "contains 5% nicotine"
  7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.
Experimental: Original - Labeling Condition 2
Participants will view an image of a white colored and original vape with label condition 2.
Other: Vaping Device Labeling

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.

The label conditions are:

  1. plain (i.e., no labeling on device)
  2. "contains THC"
  3. "contains 80% THC"
  4. "contains 80% THC - HIGH POTENCY"
  5. "contains nicotine"
  6. "contains 5% nicotine"
  7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.
Experimental: Original - Labeling Condition 3
Participants will view an image of a white colored and original vape with label condition 3.
Other: Vaping Device Labeling

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.

The label conditions are:

  1. plain (i.e., no labeling on device)
  2. "contains THC"
  3. "contains 80% THC"
  4. "contains 80% THC - HIGH POTENCY"
  5. "contains nicotine"
  6. "contains 5% nicotine"
  7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.
Experimental: Original - Labeling Condition 4
Participants will view an image of a white colored and original vape with label condition 4.
Other: Vaping Device Labeling

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.

The label conditions are:

  1. plain (i.e., no labeling on device)
  2. "contains THC"
  3. "contains 80% THC"
  4. "contains 80% THC - HIGH POTENCY"
  5. "contains nicotine"
  6. "contains 5% nicotine"
  7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.
Experimental: Original - Labeling Condition 5
Participants will view an image of a white colored and original vape with label condition 5.
Other: Vaping Device Labeling

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.

The label conditions are:

  1. plain (i.e., no labeling on device)
  2. "contains THC"
  3. "contains 80% THC"
  4. "contains 80% THC - HIGH POTENCY"
  5. "contains nicotine"
  6. "contains 5% nicotine"
  7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.
Experimental: Original - Labeling Condition 6
Participants will view an image of a white colored and original vape with label condition 6.
Other: Vaping Device Labeling

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.

The label conditions are:

  1. plain (i.e., no labeling on device)
  2. "contains THC"
  3. "contains 80% THC"
  4. "contains 80% THC - HIGH POTENCY"
  5. "contains nicotine"
  6. "contains 5% nicotine"
  7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.
Experimental: Original - Labeling Condition 7
Participants will view an image of a white colored and original vape with label condition 7.
Other: Vaping Device Labeling

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.

The label conditions are:

  1. plain (i.e., no labeling on device)
  2. "contains THC"
  3. "contains 80% THC"
  4. "contains 80% THC - HIGH POTENCY"
  5. "contains nicotine"
  6. "contains 5% nicotine"
  7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.
Experimental: Blueberry - Labeling Condition 1
Participants will view an image of a blue-colored and blueberry flavored vape with label condition 1.
Other: Vaping Device Labeling

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.

The label conditions are:

  1. plain (i.e., no labeling on device)
  2. "contains THC"
  3. "contains 80% THC"
  4. "contains 80% THC - HIGH POTENCY"
  5. "contains nicotine"
  6. "contains 5% nicotine"
  7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.
Experimental: Blueberry - Labeling Condition 2
Participants will view an image of a blue-colored and blueberry flavored vape with label condition 2.
Other: Vaping Device Labeling

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.

The label conditions are:

  1. plain (i.e., no labeling on device)
  2. "contains THC"
  3. "contains 80% THC"
  4. "contains 80% THC - HIGH POTENCY"
  5. "contains nicotine"
  6. "contains 5% nicotine"
  7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.
Experimental: Blueberry - Labeling Condition 3
Participants will view an image of a blue-colored and blueberry flavored vape with label condition 3.
Other: Vaping Device Labeling

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.

The label conditions are:

  1. plain (i.e., no labeling on device)
  2. "contains THC"
  3. "contains 80% THC"
  4. "contains 80% THC - HIGH POTENCY"
  5. "contains nicotine"
  6. "contains 5% nicotine"
  7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.
Experimental: Blueberry - Labeling Condition 4
Participants will view an image of a blue-colored and blueberry flavored vape with label condition 4.
Other: Vaping Device Labeling

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.

The label conditions are:

  1. plain (i.e., no labeling on device)
  2. "contains THC"
  3. "contains 80% THC"
  4. "contains 80% THC - HIGH POTENCY"
  5. "contains nicotine"
  6. "contains 5% nicotine"
  7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.
Experimental: Blueberry - Labeling Condition 5
Participants will view an image of a blue-colored and blueberry flavored vape with label condition 5.
Other: Vaping Device Labeling

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.

The label conditions are:

  1. plain (i.e., no labeling on device)
  2. "contains THC"
  3. "contains 80% THC"
  4. "contains 80% THC - HIGH POTENCY"
  5. "contains nicotine"
  6. "contains 5% nicotine"
  7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.
Experimental: Blueberry - Labeling Condition 6
Participants will view an image of a blue-colored and blueberry flavored vape with label condition 6.
Other: Vaping Device Labeling

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.

The label conditions are:

  1. plain (i.e., no labeling on device)
  2. "contains THC"
  3. "contains 80% THC"
  4. "contains 80% THC - HIGH POTENCY"
  5. "contains nicotine"
  6. "contains 5% nicotine"
  7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.
Experimental: Blueberry - Labeling Condition 7
Participants will view an image of a blue-colored and blueberry flavored vape with label condition 1.
Other: Vaping Device Labeling

Participants will view one vape image (experimental stimulus) and are randomized to a label presented and the color/flavor of the vaping device presented.

The label conditions are:

  1. plain (i.e., no labeling on device)
  2. "contains THC"
  3. "contains 80% THC"
  4. "contains 80% THC - HIGH POTENCY"
  5. "contains nicotine"
  6. "contains 5% nicotine"
  7. "contains 5% nicotine - HIGH STRENGTH" The color/flavor conditions are: mint/mint, white/original, blue/blueberry.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Use Intention Susceptibility
Time Frame: 5 minutes
This 3-item self-report measure assesses participant interest in trying the vaping device in the future. A 4-level Likert scale is used: definitely not, probably not, probably yes, definitely yes.
5 minutes
Perceived Health Harms
Time Frame: 5 minutes
This 2-item self-report measure assesses participant perception of health harms and risks associated with using the vaping product. A 4-level Likert scale is used: definitely not, probably not, probably yes, definitely yes.
5 minutes
Anticipated Subjective Effects
Time Frame: 5 minutes
This 9-item self-report measure assesses anticipated subjective effects from using the vaping device. Participants will select all that apply.
5 minutes
Anticipated Impairment/Enhancement
Time Frame: 5 minutes
This 4-item self-report measure assesses participant anticipated enhancement or impairment effects on completing different activities due to using the vaping product. A 5-level Likert scale is used: definitely make it harder, probably make it harder, no effect, probably make it easier, definitely make it easier.
5 minutes

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Southern California

Collaborators

National Institute on Drug Abuse (NIDA)
National Cancer Institute (NCI)

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 3, 2025

Primary Completion (Actual)

May 1, 2025

Study Completion (Actual)

June 1, 2025

Study Registration Dates

First Submitted

February 28, 2025

First Submitted That Met QC Criteria

April 4, 2025

First Posted (Actual)

April 9, 2025

Study Record Updates

Last Update Posted (Actual)

May 22, 2026

Last Update Submitted That Met QC Criteria

May 21, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • UP-23-00483/HS-19-00682
  • 5K24DA048160 (U.S. NIH Grant/Contract)
  • 5U54CA180905-12 (U.S. NIH Grant/Contract)
  • 5R01CA229617-06 (U.S. NIH Grant/Contract)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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