Comparison of Anterior Chamber Depth in High Myopes

April 23, 2025 updated by: Manar Moner jawarji, Assiut University

Comparison of Anterior Chamber Depth Measured by Anterior Segment Optical Coherence Tomography , Ultrasound and Pentacam in High Myopes

This study aims to compare the accuracy and reliability of anterior chamber depth (ACD) measurements obtained using three imaging modalities: anterior segment optical coherence tomography (A-S OCT), ultrasound biomicroscopy (UBM), and the Pentacam Scheimpflug imaging system. The research focuses on high myopic patients and evaluates the consistency and correlation of these measurements with the degree of myopia.

Study Overview

Status

Not yet recruiting

Conditions

Detailed Description

The research is a cross-sectional, prospective, observational cohort study conducted in ophthalmological settings at Assiut University Hospital, Elforsan Center, and Tyba Center. It investigates the anterior chamber depth (ACD) in high myopes using three advanced diagnostic imaging tools:

Anterior Segment Optical Coherence Tomography (A-S OCT): A non-invasive imaging technique for high-resolution cross-sectional imaging of the anterior segment.

Ultrasound Biomicroscopy (UBM): An imaging method that uses high-frequency ultrasound to visualize anterior segment structures.

Pentacam HR (Scheimpflug Imaging System): A device that provides three-dimensional imaging of the anterior chamber.

The primary objective is to determine the mean differences in ACD measurements among these devices. Secondary objectives include assessing the correlation between ACD measurements and the degree of myopia, as well as evaluating the repeatability of measurements for each device.

Study Type

Observational

Enrollment (Estimated)

30

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Probability Sample

Study Population

study population consists of adult patients (aged 18 years or older) with high myopia, defined as an axial length greater than 26 mm or a refractive error exceeding -6.00 diopters (D). Participants must be able to fixate for imaging procedures.

Description

Inclusion Criteria:

  • Patients aged 18 years or older

    • High myopes with axial length >26mm or , and refractive error > -6 ,00 D
    • Ability to fixate for OCT and Pentacam imaging

Exclusion Criteria:

  • History of ocular surgery or trauma

    • Presence of corneal pathology
    • Active ocular inflammation
    • Inability to fixate for imaging procedure

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
adult patients (aged 18 years or older) with high myopia
The study population consists of adult patients (aged 18 years or older) with high myopia, defined as an axial length greater than 26 mm or a refractive error exceeding -6.00 diopters (D). Participants must be able to fixate for imaging procedures.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Mean difference in ACD measurements between A-S OCT, UBM, and Pentacam.
Time Frame: During the procedure
The study will calculate and compare the average differences in anterior chamber depth measurements obtained by each device to assess their accuracy and reliability.
During the procedure

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Assiut University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

  • Smith A, Johnson B, Lee C. Anterior chamber depth measurement in high myopia: A comparative analysis. J Cataract Refract Surg. 2021;47(5):612-620.
  • Wan T, Ding X, Sun Y. Swept-source OCT for anterior segment imaging in high myopia. BMC Ophthalmol. 2021;21(1):62.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

September 30, 2025

Primary Completion (Estimated)

August 30, 2026

Study Completion (Estimated)

October 30, 2026

Study Registration Dates

First Submitted

April 9, 2025

First Submitted That Met QC Criteria

April 23, 2025

First Posted (Actual)

April 27, 2025

Study Record Updates

Last Update Posted (Actual)

April 27, 2025

Last Update Submitted That Met QC Criteria

April 23, 2025

Last Verified

April 1, 2025

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • anterior chamber depth measure

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Anterior Chamber Depth

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Nigeria

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe