Acute Cardiovascular Responses to Two Types of Exercise

June 11, 2025 updated by: Dr. Stephen Mark Cornish, University of Manitoba

The Effect of Aerobic Exercise With and Without Neuromuscular Electrical Stimulation on Acute Cardiovascular Responses Between Biological Sexes

The purpose of this research was to explore potential differences in acute cardiovascular responses between two conditions: 1) moderate-intensity cycle ergometer exercise; and 2) moderate-intensity cycle ergometer exercise with NMES. Young, healthy, physically active participants were recruited for this study.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

20

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Canada
    • Manitoba
      • Winnipeg, Manitoba, Canada, R3T2N2
        • Active Living Centre/Applied Research Centre

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • healthy
  • performing aerobic activity greater than or equal to three times per week at any intensity

Exclusion Criteria:

  • had lower body musculoskeletal injuries recently (within the past 6 months)
  • health conditions that may place risk to the individual such as those with respiratory issues, hypertension, chronic atrial fibrillation, valvular diseases, heart disease; or obstructive cardiomyopathy
  • if taking pharmacological drugs, performance-enhancing drugs, recreational drugs, nutritional supplements, or smoked nicotine

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Aerobic exercise alone
Participants completed aerobic exercise acutely
Behavioral: Aerobic exercise
Aerobic exercise was done with and without neuromuscular electrical stimulation
Experimental: Aerobic exercise with neuromuscular electrical stimulation of the leg musculature
Participants completed aerobic exercise with neuromuscular electrical stimulation
Behavioral: Aerobic exercise
Aerobic exercise was done with and without neuromuscular electrical stimulation

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Oxygen consumption
Time Frame: 20 minutes
L/min
20 minutes

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Carbon dioxide production
Time Frame: 20 minutes
L/min
20 minutes
Heart rate
Time Frame: 20 minutes
bpm
20 minutes
Respiratory exchange ratio
Time Frame: 20 minutes
RER (0.70-1.00)
20 minutes
Rating of perceived exertion
Time Frame: 20 minutes
RPE (6-20)
20 minutes
Kilocalories utilized
Time Frame: 20 minutes
kcal/min
20 minutes
Carbohydrate utilized
Time Frame: 20 minutes
g/min
20 minutes
Fats utilized
Time Frame: 20 minutes
g/min
20 minutes

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Manitoba

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 25, 2022

Primary Completion (Actual)

June 1, 2023

Study Completion (Actual)

June 1, 2023

Study Registration Dates

First Submitted

June 4, 2025

First Submitted That Met QC Criteria

June 4, 2025

First Posted (Actual)

June 11, 2025

Study Record Updates

Last Update Posted (Actual)

June 15, 2025

Last Update Submitted That Met QC Criteria

June 11, 2025

Last Verified

June 1, 2025

More Information

Terms related to this study

Other Study ID Numbers

  • HE2021-0209

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

IPD Plan Description

Will decide if asked by other investigators.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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